Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Heterochromatin/genetics"'
Autor:
Abreu, Ana Paula Santana de
Estudos sugerem que a presença de células metastáticas ocultas em medula óssea pode ser fator prognóstico em câncer de mama. Além disso, é possível que um perfil gênico tumoral específico, caracterizado por repressão da expressão gênica
Autor:
Kajitani, T., Kato, H., Chikashige, Y., Tsutsumi, C., Hiraoka, Y., Kimura, Hiroshi, Ohkawa, Y., Obuse, C., Hermand, D., Murakami, Y.
Publikováno v:
Kajitani, T, Kato, H, Chikashige, Y, Tsutsumi, C, Hiraoka, Y, Kimura, H, Ohkawa, Y, Obuse, C, Hermand, D & Murakami, Y 2017, ' Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 52, pp. E11208-E11217 . https://doi.org/10.1073/pnas.1714579115
Some long noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (RNAPII) are retained on chromatin, where they regulate RNAi and chromatin structure. The molecular basis of this retention remains unknown. We show that in fission yeast serine 7 (Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c46f933de443b0df22f3fb24f9e3800
https://doi.org/10.1073/pnas.1714579115
https://doi.org/10.1073/pnas.1714579115
Autor:
Erik L. Miller, Simon M. G. Braun, Gerald R. Crabtree, Emma J. Chory, Cigall Kadoch, Robert T Williams, Joseph P Calarco, Christopher M. Weber, John L. Pulice
Publikováno v:
Nature Genetics, Vol. 49, No 2 (2017) pp. 213-222
Nature genetics
Nature genetics
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d75515730584b4cfcebecce938e942
https://archive-ouverte.unige.ch/unige:154520
https://archive-ouverte.unige.ch/unige:154520
Autor:
Mishima, Y., Watanabe, M., Kawakami, T., Jayasinghe, C. D., Otani, J., Kikugawa, Y., Shirakawa, M., Kimura, Hiroshi, Nishimura, O., Aimoto, S., Tajima, S., Suetake, I.
Publikováno v:
Journal of molecular biology. 425(No. 1):54-70
The majority of the genome in eukaryotes is packaged into transcriptionally inactive chromatin. Heterochromatin protein 1 (HP1) is a major player in the establishment and maintenance of heterochromatin. HP1 specifically recognizes a methylated lysine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fb93558d770001d0ef42998b0a73fe
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100714614
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100714614
Autor:
Koen Devriendt, Jean-Pierre Fryns, Lieven Lagae, Peter Marynen, Maria Syrrou, Suzanna G M Frints
Publikováno v:
Annales de Génétique. 44:71-76
We report clinical and molecular investigations in a boy with karyotype 46,Y,der(X)t(X;Y)(qter-->p22.3::q11.21-->qter) and his mother with karyotype 46,X,der(X)t(X;Y)(qter-->p22.3::q11.21-->qter). Haplo-insufficiency for the Xp22.3-->pter chromosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7259d7b24a39629f2e85bcfa6552706
https://doi.org/10.1016/s0003-3995(01)01071-1
https://doi.org/10.1016/s0003-3995(01)01071-1
Autor:
Ole N. Jensen, Veit Schwämmle
Publikováno v:
PLoS ONE
Schwämmle, V & Jensen, O N 2013, ' A Computational Model for Histone Mark Propagation Reproduces the Distribution of Heterochromatin in Different Human Cell Types ', P L o S One, vol. 8, no. 9, e73818, pp. e73818 . https://doi.org/10.1371/journal.pone.0073818
PLoS ONE, Vol 8, Iss 9, p e73818 (2013)
Schwämmle, V & Jensen, O N 2013, ' A Computational Model for Histone Mark Propagation Reproduces the Distribution of Heterochromatin in Different Human Cell Types ', P L o S One, vol. 8, no. 9, e73818, pp. e73818 . https://doi.org/10.1371/journal.pone.0073818
PLoS ONE, Vol 8, Iss 9, p e73818 (2013)
Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it. Histone proteins are implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a2d3251406af9b8a666220c36aed5c
https://pubmed.ncbi.nlm.nih.gov/24069233
https://pubmed.ncbi.nlm.nih.gov/24069233
Autor:
Etienne Bucher, Isabelle Vaillant, Olivier Mathieu, Larissa Broger, Mireille Tittel-Elmer, Jerzy Paszkowski
Publikováno v:
PLoS Genetics
PLoS Genetics, 2010, 6 (10), pp.e1001175. ⟨10.1371/journal.pgen.1001175⟩
PLOS Genetics, Vol. 6, No 10 (2010) P. e1001175
PLoS Genetics, Public Library of Science, 2010, 6 (10), pp.e1001175. ⟨10.1371/journal.pgen.1001175⟩
PLoS Genetics, Vol 6, Iss 10, p e1001175 (2010)
Scopus-Elsevier
PLoS Genetics, 2010, 6 (10), pp.e1001175. ⟨10.1371/journal.pgen.1001175⟩
PLOS Genetics, Vol. 6, No 10 (2010) P. e1001175
PLoS Genetics, Public Library of Science, 2010, 6 (10), pp.e1001175. ⟨10.1371/journal.pgen.1001175⟩
PLoS Genetics, Vol 6, Iss 10, p e1001175 (2010)
Scopus-Elsevier
Constitutive heterochromatin comprising the centromeric and telomeric parts of chromosomes includes DNA marked by high levels of methylation associated with histones modified by repressive marks. These epigenetic modifications silence transcription a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61df023c3c7dc09f4f2f1c3604159c7
https://hal.uca.fr/hal-01917179
https://hal.uca.fr/hal-01917179
Autor:
Muhammad Tariq, Jerzy Paszkowski, Chotika Smathajitt, Olivier Mathieu, Tong Zhu, Aline V. Probst, Yoshiki Habu
Publikováno v:
EMBO Reports
EMBO Reports, 2006, 7 (12), pp.1279-1284. ⟨10.1038/sj.embor.7400835⟩
EMBO Reports, EMBO Press, 2006, 7 (12), pp.1279-1284. ⟨10.1038/sj.embor.7400835⟩
EMBO Reports, Vol. 7, No 12 (2006) pp. 1279-84
EMBO Reports, 2006, 7 (12), pp.1279-1284. ⟨10.1038/sj.embor.7400835⟩
EMBO Reports, EMBO Press, 2006, 7 (12), pp.1279-1284. ⟨10.1038/sj.embor.7400835⟩
EMBO Reports, Vol. 7, No 12 (2006) pp. 1279-84
International audience; Constitutive heterochromatin is a compact, transcriptionally inert structure formed in gene-poor and repeat- and transposon-rich regions. In Arabidopsis, constitutive heterochromatin is characterized by hypermethylated DNA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c31aecc7d3885b2c82ee9013f2960f
https://uca.hal.science/hal-01917198
https://uca.hal.science/hal-01917198
Autor:
Ana Paula Santana de Abreu
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Estudos sugerem que a presença de células metastáticas ocultas em medula óssea pode ser fator prognóstico em câncer de mama. Além disso, é possível que um perfil gênico tumoral específico, caracterizado por repressão da expressão gênica
Autor:
Tokuko Haraguchi, Fangwei Wang, Toshiro Tsukamoto, Naoki Koyama, Hiroko Nishida, Walter Reith
Publikováno v:
Molecular and Cellular Biology, Vol. 26, No 11 (2006) pp. 4028-4040
A role for the RNA interference (RNAi) pathway in the establishment of heterochromatin is now well accepted for various organisms. Less is known about its relevance and precise role in mammalian cells. We previously showed that tandem insertion of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76ffc2a94c4716218ce73c04190c3d6
https://archive-ouverte.unige.ch/unige:11630
https://archive-ouverte.unige.ch/unige:11630