Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hetalben Patel"'
Publikováno v:
Case Reports in Medicine, Vol 2012 (2012)
Aspiration of tracheobronchial foreign bodies is a life-threatening event that occurs mainly in children. Occurrence in adults is rare and usually has a subtle presentation as most adults are unaware of aspiration of any foreign material. Decreased l
Externí odkaz:
https://doaj.org/article/c1d036ab3fd7444090f31d14732ab941
Autor:
Natalia S. Nemeria, Junjie Wang, Hetalben Patel, Vera Adam-Vizi, Jieyu Zhou, Frank Jordan, Gary J. Gerfen, Laszlo Tretter, Attila Ambrus
Publikováno v:
Journal of Biological Chemistry. 289:29859-29873
Herein are reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle. (a) Functionally competent 2-oxoglutarate dehydrogenase (E1o-h) and dihydrolipoyl su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7f6ada2c504092804760712d235c51
https://doi.org/10.1074/jbc.m114.591073
https://doi.org/10.1074/jbc.m114.591073
Autor:
Frank Jordan, Hetalben Patel, Caren L. Freel Meyers, Lazaros Kakalis, Leighanne A. Brammer Basta
Publikováno v:
FEBS Journal. 281:2820-2837
1-Deoxy-D-xylulose 5-phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and D-glyceraldehyde 3-phosphate (GraP) in a thiamin diphosphate-dependent manner, and is the first step in the essential pathway to isoprenoids in human patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcf256b7800db37688c05ea13ed6102
https://doi.org/10.1111/febs.12823
https://doi.org/10.1111/febs.12823
Publikováno v:
Biochemistry
Identification of enzyme-bound intermediates via their spectroscopic signatures, which then allows direct monitoring of the kinetic fate of these intermediates, poses a continuing challenge. As an electrophilic covalent catalyst, the thiamin diphosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469cdcb24e6e74de40dd0679fc58e8ad
http://europepmc.org/articles/PMC3985856
http://europepmc.org/articles/PMC3985856
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 98:42-45
The potential of thiamin diphosphate (ThDP)-dependent enzymes to catalyze C C bond forming (carboligase) reactions with high enantiomeric excess has been recognized for many years. Here we report the application of the E1 component of the Escherichia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1714b5aa9d5e8e4a09f42b33a7ccbc16
https://doi.org/10.1016/j.molcatb.2013.09.010
https://doi.org/10.1016/j.molcatb.2013.09.010
Autor:
William G. Kaelin, Gary J. Gerfen, Shugeng Cao, Benjamin A. Olenchock, Peppi Koivunen, Keriann M. Backus, Sabina Signoretti, Qing Zhang, Kimberly J. Briggs, Hetalben Patel, Andrea L L. Richardson, Agnieszka K. Witkiewicz, Benjamin F. Cravatt, Jon Clardy
The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The HIFα subunit is usually prolyl-hydroxylated by EglN family members under normoxic condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad3264f344ede880604bf81bd70a178
https://europepmc.org/articles/PMC4930557/
https://europepmc.org/articles/PMC4930557/
Autor:
Frank Jordan, Leighanne A. Brammer, Hetalben Patel, Caren L. Freel Meyers, Natalia S. Nemeria
Publikováno v:
Journal of the American Chemical Society. 134:18374-18379
The thiamin diphosphate (ThDP)-dependent enzyme 1-deoxy-D-xylulose 5-phosphate (DXP) synthase carries out the condensation of pyruvate as a 2-hydroxyethyl donor with d-glyceraldehyde-3-phosphate (d-GAP) as acceptor forming DXP. Toward understanding c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cf40a7c37b9b0bc99f2e773a3dc607
https://doi.org/10.1021/ja307315u
https://doi.org/10.1021/ja307315u
Autor:
Frank Jordan, Hetalben Patel
This review is focused on three types of enzymes decarboxylating very different substrates: (1) Thiamin diphosphate (ThDP)-dependent enzymes reacting with 2-oxo acids; (2) Pyridoxal phosphate (PLP)-dependent enzymes reacting with α-amino acids; and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee5e1cd2c2ef909df7881f3f8d4cd52
https://europepmc.org/articles/PMC3728911/
https://europepmc.org/articles/PMC3728911/
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9883d7b1be77e857ac0a493b1d1bb9b
https://doi.org/10.1096/fasebj.27.1_supplement.789.19
https://doi.org/10.1096/fasebj.27.1_supplement.789.19
Autor:
David M. Chipman, Hetalben Patel, Frank Jordan, Ilan Vered, Anand Balakrishnan, Elad Binshtein, Boaz Shaanan, Ze'ev Barak, Natalia Nemeria
Publikováno v:
Biochemistry. 51(40)
Glyoxylate carboligase (GCL) is a thiamin diphosphate (ThDP)-dependent enzyme, which catalyzes the decarboxylation of glyoxylate and ligation to a second molecule of glyoxylate to form tartronate semialdehyde (TSA). This enzyme is unique among ThDP e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f465de576dcf05d2fc086402dbf0a18
https://pubmed.ncbi.nlm.nih.gov/22970650
https://pubmed.ncbi.nlm.nih.gov/22970650