Výsledky vyhledávání - "Hester Koppejan"

Akademický článek

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Autor: Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes, Floris A. van Gaalen

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-7 (2019)

Abstract Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflammatory disease develo

Externí odkaz: https://doaj.org/article/1ca0d237c8f44524813859166c7572b3

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Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

Autor: Marjolijn Hameetman, J.C. Kwekkeboom, Vincent van Unen, A.H.M. van der Helm-van Mil, Guillaume Beyrend, F. A. van Gaalen, Rem Toes, Hester Koppejan

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Arthritis Research and Therapy, 23(1). BMC

Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to ACPA-neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ea73d0021e2ca9456256af6ef985e0
http://europepmc.org/articles/PMC8555233

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Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Autor: Marjolijn Hameetman, Floris A. van Gaalen, Hester Koppejan, René E. M. Toes, Ranjeny Thomas, Diahann T. S. L. Jansen

Publikováno v: Arthritis Research and Therapy, 21
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-7 (2019)
Arthritis Research & Therapy, 21:3. BioMed Central Ltd.

Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflammatory disease development. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939a8ec024b3f82ae15451b171734fe2
http://hdl.handle.net/1887/88279

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Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load

Autor: Blandine Franke-Fayard, Meta Roestenberg, Severine Chevalley-Maurel, Simone Haeberlein, Arifa Ozir-Fazalalikhan, Robert W. Sauerwein, Beatrice M. F. Winkel, Chris J. Janse, Hermelijn H. Smits, Jai Ramesar, Hester Koppejan, Shahid M. Khan

Publikováno v: Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)
Scientific Reports

In humans and murine models of malaria, intradermal immunization (ID-I) with genetically attenuated sporozoites that arrest in liver induces lower protective immunity than intravenous immunization (IV-I). It is unclear whether this difference is caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870b61c8a084d8f7d2b9480f5c46bbb8
https://doi.org/10.1038/s41598-017-10480-1

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Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure

Autor: Søren R. Paludan, Sanne L. Landman, Anna M. Gram, Rob C. Hoeben, Timo Oosenbrug, Mark J. Kwakkenbos, Maaike E. Ressing, Chenglong Sun, Hester Koppejan

Publikováno v: Gram, A M, Sun, C, Landman, S L, Oosenbrug, T, Koppejan, H J, Kwakkenbos, M J, Hoeben, R C, Paludan, S R & Ressing, M E 2017, ' Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure ', Molecular Immunology, vol. 91, pp. 225-237 . https://doi.org/10.1016/j.molimm.2017.08.025
Molecular Immunology, 91, 225-237

Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a222b4b168da0eb391c1cb38bcbc1ee
https://pubmed.ncbi.nlm.nih.gov/28968560

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Inactivation of DNA Mismatch Repair by Variants of Uncertain Significance in the PMS2 Gene

Autor: Hester Koppejan, Mark Drost, Niels de Wind

Publikováno v: Human Mutation, 34(11), 1477-1480

Lynch syndrome (LS) is a common cancer predisposition caused by an inactivating mutation in one of four DNA mismatch repair (MMR) genes. Frequently a variant of uncertain significance (VUS), rather than an obviously pathogenic mutation, is identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29107061410191beb2959a7898288999
https://doi.org/10.1002/humu.22426

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Autor: Carol A. Hitchon, Leendert A. Trouw, Hester Koppejan, Hani El-Gabalawy, Rem Toes, Tom J.W. Huizinga

Publikováno v: Arthritis & Rheumatology. 68:2826-2827

Hutchinson and colleagues in their Letter to the Editor propose a novel hypothesis in which modified-misfolded proteins such as immunoglobulin, in the setting of a permissive genetic background, might be a common link for the three autoantibody syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15d6d82e7ead8c668e99a93e295790ad
https://doi.org/10.1002/art.39831

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