Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hesta McNeill"'
Autor:
Vasily V. Grinev, Farnaz Barneh, Ilya M. Ilyushonak, Sirintra Nakjang, Job Smink, Anita van Oort, Richard Clough, Michael Seyani, Hesta McNeill, Mojgan Reza, Natalia Martinez-Soria, Salam A. Assi, Tatsiana V. Ramanouskaya, Constanze Bonifer, Olaf Heidenreich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5’UTR, altering isoform expression, and controlling
Externí odkaz:
https://doaj.org/article/5eec00d838bf48d7a8a72e936547e1a8
Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc1d67bb85567d28d48decb91162f8
https://doi.org/10.1182/blood.2021015036
https://doi.org/10.1182/blood.2021015036
Autor:
Heidenreich Olaf, J. Christine Harrison, Andrew Filby, Lisa J. Russell, Paul Sinclair, Shalini Sankar, Nakjang Sirintra, Ryan Nelson, Christina Halsey, Hesta McNeill, Jonathan Coxhead, Josef Vormoor, Deepali Pal, Mankaran Singh, A Isa, James M. Allan, Anthony V. Moorman, Angel Hanmy Sharon, Peixun Zhous, Andrew Fuller, Ricky Tirtakusuma, Claire Schwab, Aaron Wilson, Salem Nizami, M Beckett, Helen J. Blair, Sophie Boyd, Carly Knill
Leukaemia cells re-program their microenvironment to provide proliferation support and protection from standard chemotherapy, molecularly targeted therapies, and immunotherapy. Although much is becoming known about molecules that drive niche-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f1d362570004df218376e6c75b48ed6
https://doi.org/10.1101/2021.06.18.448490
https://doi.org/10.1101/2021.06.18.448490
Autor:
Salam A. Assi, Michael Seyani, Vasily V. Grinev, Mojgan Reza, N Martinez-Soria, Tatsiana V. Ramanouskaya, Anita van Oort, Hesta McNeill, Sirintra Nakjang, Job Smink, Constanze Bonifer, Olaf Heidenreich, Richard Clough, Ilya M. Ilyushonak, Farnaz Barneh
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The fusion oncogene RUNX1/RUNX1T1 encodes an aberrant transcription factor, which plays a key role in the initiation and maintenance of acute myeloid leukemia. Here we show that the RUNX1/RUNX1T1 oncogene is a regulator of alternative RNA splicing in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dace14325547570ede9ed3dad87f4b89
http://europepmc.org/articles/PMC7822815
http://europepmc.org/articles/PMC7822815
Autor:
Simon Bomken, James C. Mulloy, Peter Carey, Zoya Kingsbury, Josef Vormoor, Paul Milne, Christine J. Harrison, Helen Blair, Jennifer Becq, Lisa J. Russell, Peter N. Cockerill, Jean-Baptiste Cazier, Constanze Bonifer, Daniel Williamson, James M Allan, Paul Evans, Anetta Ptasinska, Sirintra Nakjang, Maria Rosaria Imperato, Elena Zerkalenkova, Rolf Marschalek, Michael J. Thirman, Shan Lin, Alex Smith, Natalia Miakova, Muzlifa Haniffa, Ricky Tirtakusuma, Simon Bailey, Salam A. Assi, Catherine Cargo, Pierre Cauchy, Y Shi, Hesta McNeill, Yulia Olshanskaya, Fotini Vogiatzi, Claus Meyer, Sarah E. Fordham, Alex Elder, Matthew Collin, Roderick Skinner, Venetia Bigley, Olaf Heidenreich, A Komkov, Cornelia Eckert, Deepali Pal, Denis M. Schewe, N Martinez-Soria, Oskar A. Haas
Publikováno v:
SSRN Electronic Journal.
SummaryThe translocation MLL-AF4 defines a high-risk subtype of acute leukaemia which, uniquely amongst MLL translocations, is almost exclusively associated with a pro-B lymphoid phenotype. However, the ability to switch lineage at relapse allowed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8147925f93c78a7360a68fde7683cdc4
https://doi.org/10.2139/ssrn.3432467
https://doi.org/10.2139/ssrn.3432467
Autor:
Hesta McNeill, Helen J. Blair, E Law, Julie Irving, J. Luec, Katarzyna Szoltysek, Josef Vormoor, D. Pal, Olaf Heidenreich, S. Bomken, L McKenzie
Publikováno v:
HemaSphere. 3:412-413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13056208e70497a98034e7e75830f860
https://doi.org/10.1097/01.hs9.0000561940.53759.ef
https://doi.org/10.1097/01.hs9.0000561940.53759.ef
Autor:
Hesta McNeill, Sirintra Nakjang, Ricky Tirtakusuma, Deepali Pal, L McKenzie, Katarzyna Szoltysek, Josef Vormoor, Olaf Heidenreich, Catherine Dodd, Mankaran Singh, Ryan W. Nelson, Helen J. Blair, M Beckett, E Law
Publikováno v:
Blood. 134:3952-3952
Acute lymphoblastic leukemia (ALL) is the most common type of childhood leukaemia. Recently improved risk stratification resulted in therapy optimization and extended survival for the majority of cases. Unfortunately, there is still a significant num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c466eb6525fb4fc8cc6b96e72e826268
https://doi.org/10.1182/blood-2019-124818
https://doi.org/10.1182/blood-2019-124818
Autor:
Frida Ponthan, Hesta McNeill, Miriam Guillen Navarro, Shalini Sankar, Michel Zwaan, Josef Vormoor, Olaf Heidenreich, Vasily V. Grinev, Sirintra Nakjang, Ronald W. Stam, Simon Bomken
Publikováno v:
Blood. 134:1237-1237
To identify potential regulators of propagation and self-renewal of Acute Lymphoblastic Leukaemia (ALL), we performed an explorative genome-wide RNAi screen followed by CRISPR ex vivo and in vivo validation screens in the t(4;11)-positive ALL cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fe7ca317f82010a7fd509c57b579eee
https://doi.org/10.1182/blood-2019-124787
https://doi.org/10.1182/blood-2019-124787
Molecular Parameters of siRNA–Cell Penetrating Peptide Nanocomplexes for Efficient Cellular Delivery
Autor:
Petra H. M. Bovee-Geurts, Staffan Lindberg, Andrea Beyerle, Roland Brock, Olaf Heidenreich, Mattias Hällbrink, Hesta McNeill, Alexander Henrik Baron Van Asbeck, Ülo Langel, Wouter P. R. Verdurmen
Publikováno v:
ACS Nano, 7, 5, pp. 3797-807
ACS Nano, 7, 3797-807
ACS Nano, 7, 3797-807
Item does not contain fulltext Cell-penetrating peptides (CPPs) are versatile tools for the intracellular delivery of various biomolecules, including siRNA. Recently, CPPs were introduced that showed greatly enhanced delivery efficiency. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2713e7fc09713058a8de0873bc8f135a
https://doi.org/10.1021/nn305754c
https://doi.org/10.1021/nn305754c
Autor:
Bryan D. Young, Daniel G. Tenen, Pierre Cauchy, Daniel Williamson, Maarten Hoogenkamp, Hesta McNeill, David R. Westhead, Reuben Tooze, J Dunne, M Cullen, Constanze Bonifer, Matthew A. Care, Peter N. Cockerill, Olaf Heidenreich, Mengchu Wu, Sally R. James, Salam A. Assi, Anetta Ptasinska, D Mannari
Publikováno v:
Leukemia
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cb146fb5db222b5048605695829f91
https://doi.org/10.1038/leu.2012.49
https://doi.org/10.1038/leu.2012.49