Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Autor: Phong D. Nguyen, Iris Gooijers, Giulia Campostrini, Arie O. Verkerk, Hessel Honkoop, Mara Bouwman, Dennis E. M. de Bakker, Tim Koopmans, Aryan Vink, Gerda E. M. Lamers, Avraham Shakked, Jonas Mars, Aat A. Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L. Mummery, Teun P. de Boer, Milena Bellin, Jeroen Bakkers

Publikováno v: Science, 380(6646), 758-764. American Association for the Advancement of Science

Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943bee9c72057afcf68114b824ca5b6c
https://doi.org/10.1126/science.abo6718

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Autor: Judith Klumperman, Joshua Craiger Peterson, Willem J van der Laarse, Wendy Noort, Richard T. Jaspers, Mauro J. Muraro, Kenneth D. Poss, Eldad Tzahor, Phong D. Nguyen, Avraham Shakked, George Posthuma, Gilbert Weidinger, Alla Aharonov, Fabian Kruse, Federico Tessadori, Alexander van Oudenaarden, Alberto Bertozzi, Adam R. Shoffner, Dennis E. M. de Bakker, Hessel Honkoop, Cecilia de Heus, Laurence Garric, Dominic Grün, Jeroen Bakkers

Publikováno v: eLife
Honkoop, H, de Bakker, D E M, Aharonov, A, Kruse, F, Shakked, A, Nguyen, P D, de Heus, C, Garric, L, J Muraro, M, Shoffner, A, Tessadori, F, Peterson, J C, Noort, W, Bertozzi, A, Weidinger, G, Posthuma, G, Grün, D, van der Laarse, W J, Klumperman, J, Jaspers, R T, Poss, K D, van Oudenaarden, A, Tzahor, E & Bakkers, J 2019, ' Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart ', eLife, vol. 8, e50163 . https://doi.org/10.7554/eLife.50163
eLife, Vol 8 (2019)
eLife, 8:e50163. eLife Sciences Publications Limited
eLife, 8. eLife Sciences Publications
eLife, 8:e50163. eLife Sciences Publications

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace the lost myocar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee66e2461ec6478fd464605d47b5f8a0
https://hdl.handle.net/20.500.11755/15cf795e-92c4-48d5-902a-d33de79eb986

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

Autor: Jeroen Bakkers, Joshua Craiger Peterson, Phong D. Nguyen, Judith Klumperman, Avraham Shakked, Dennis E. M. de Bakker, Adam R. Shoffner, Alla Aharonov, George Posthuma, Wendy Noort, Mauro J. Muraro, Kenneth D. Poss, Willem J van der Laarse, Federico Tessadori, Alexander van Oudenaarden, Eldad Tzahor, Laurence Garric, Richard T. Jaspers, Fabian Kruse, Dominic Grün, Hessel Honkoop, Cecilia de Heus

Summary The capacity to regenerate damaged tissues, such as the heart, various enormously amongst species. While heart regeneration is generally very low in mammals 1–3, it can regenerate efficiently in certain amphibian and fish species 4,5. Zebra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a415056eb82b91381fd9da28062c0f6b