Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Heshan Sam Zhou"'
Publikováno v:
Viruses, Vol 7, Iss 11, Pp 5767-5779 (2015)
Various viruses have been studied and developed for oncolytic virotherapies. In virotherapy, a relatively small amount of viruses used in an intratumoral injection preferentially replicate in and lyse cancer cells, leading to the release of amplified
Externí odkaz:
https://doaj.org/article/0da0f1b5cdf64a10bad9e4282f3e5b8b
Publikováno v:
Viruses, Vol 8, Iss 12, p 333 (2016)
Adenoviruses (Ads) have been extensively manipulated for the development of cancer selective replication, leading to cancer cell death or oncolysis. Clinical studies using E1-modified oncolytic Ads have shown that this therapeutic platform was safe,
Externí odkaz:
https://doaj.org/article/d6755f3efe314e7c9177043e1e248c47
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57340 (2013)
Adenoviruses (Ads) with deletion of E1b55K preferentially replicate in cancer cells and have been used in cancer therapies. We have previously shown that Ad E1B55K protein is involved in induction of cyclin E for Ad replication, but this E1B55K funct
Externí odkaz:
https://doaj.org/article/3d23b898b3e1470ebdf87b0a8823fe38
Autor:
Xiao-Mei Rao, Stephen L. Wechman, Jorge G. Gomez-Gutierrez, Kelly M. McMasters, Heshan Sam Zhou
Publikováno v:
Cancer Biology & Therapy. 19:1174-1184
Oncolytic adenoviruses (Ads) are cancer selective tumoricidal agents; however their mechanism of Ad-mediated cancer cell lysis, or oncolysis, remains undefined. This report focuses upon the autophagy mediator c-JUN n-terminal kinase (JNK) and its eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe864f2228cbebd39af4c47c7e0a734
https://doi.org/10.1080/15384047.2018.1491503
https://doi.org/10.1080/15384047.2018.1491503
Publikováno v:
Viruses, Vol 7, Iss 11, Pp 5767-5779 (2015)
Viruses
Viruses
Various viruses have been studied and developed for oncolytic virotherapies. In virotherapy, a relatively small amount of viruses used in an intratumoral injection preferentially replicate in and lyse cancer cells, leading to the release of amplified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e4aea3f6ece783387a340c377054fb
https://doi.org/10.3390/v7112905
https://doi.org/10.3390/v7112905
Autor:
Xiao-Mei Rao, Stephen L. Wechman, Kelly M. McMasters, Pei-Hsin Cheng, Jorge G. Gomez-Gutierrez, Heshan Sam Zhou
Publikováno v:
Viruses; Volume 8; Issue 6; Pages: 167
Viruses
Viruses, Vol 8, Iss 6, p 167 (2016)
Viruses
Viruses, Vol 8, Iss 6, p 167 (2016)
Oncolytic adenoviruses (Ads) have been shown to be safe and have great potential for the treatment of solid tumors. However, the therapeutic efficacy of Ads is antagonized by limited spread within solid tumors. To develop Ads with enhanced spread, vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df596ed70e987531ad04e2aeb7e9a5
Autor:
Hongying Hao, Michael E. Egger, Kelly M. McMasters, Heshan Sam Zhou, Jorge G. Gomez-Gutierrez
Publikováno v:
Cancer Biology & Therapy. 13:1195-1204
Melanoma is generally resistant to chemotherapy, which may be related to defects in death receptor signaling and to defects in induction of apoptosis. Forkhead family transcription factors induce the expression of death receptor ligands such as Fas l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540267ebd089005587d80c4f0c9949c6
https://doi.org/10.4161/cbt.21349
https://doi.org/10.4161/cbt.21349
Autor:
Jorge G. Gomez-Gutierrez, Kelly M. McMasters, Azemat Jamshidi-Parsian, Heshan Sam Zhou, Hongying Hao, Allison M. Phelps, Canming Chen, Hai Liang Yang, Yan Bin Dong
Publikováno v:
Tumor Biology. 28:111-122
In the present study, we investigate the role of apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein (MAP) kinase signal pathways in E2F-1-mediated apoptosis.A gene expression profile in response to E2F-1 overexpression was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e761adc8a3a365c79bd0960c2cfb74c
https://doi.org/10.1159/000099370
https://doi.org/10.1159/000099370
Autor:
Kelly M. McMasters, Xiao-Feng Li, Pei-Hsin Cheng, Heshan Sam Zhou, Stephen L. Wechman, Xiao-Mei Rao
Publikováno v:
BMC Cancer
Background Clinical trials have indicated that preclinical results obtained with human tumor xenografts in mouse models may overstate the potential of adenovirus (Ad)-mediated oncolytic therapies. We have previously demonstrated that the replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f456c962439f818740b7fa00e836e0b2
http://europepmc.org/articles/PMC4609153
http://europepmc.org/articles/PMC4609153
Publikováno v:
Cancer Gene Therapy. 13:572-583
E1B55K-deleted dl1520 could selectively replicate in cancer cells and has been used in clinical trials as an antitumor agent. The mechanism of virus selective replication in cancer cells, including a possible role of p53, is unclear. Studies with est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a550ca85b7b3331ad3a7a002ee2005e
https://doi.org/10.1038/sj.cgt.7700923
https://doi.org/10.1038/sj.cgt.7700923