Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hesham Shamshoum"'
Autor:
Hesham Shamshoum, Kyle D. Medak, Greg L. McKie, Stewart Jeromson, Margaret K. Hahn, David C. Wright
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115671- (2023)
Antipsychotic medications are used in the management of schizophrenia and a growing number of off-label conditions. While effective at reducing psychoses, these drugs possess noted metabolic side effects including weight gain, liver lipid accumulatio
Externí odkaz:
https://doaj.org/article/6de73a7a28604652ba7b642fa2ff7f7b
Autor:
Kyle D. Medak, Alyssa J. Weber, Hesham Shamshoum, Greg L. McKie, Margaret K. Hahn, David C. Wright
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in reducing psychoses, acute olanzapine treatment causes rapid hyperglycemia, insulin resistance, a
Externí odkaz:
https://doaj.org/article/0448274fd60e464b8b6683d703bc0b97
Publikováno v:
Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1)
Externí odkaz:
https://doaj.org/article/38b74cfed5e44708b9acc47e4a7d90dd
Publikováno v:
Nutrients, Vol 9, Iss 9, p 968 (2017)
Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods
Externí odkaz:
https://doaj.org/article/b3951d5111a4470f94a72106dc2f11b5
Publikováno v:
Obesity. 31:454-465
In contrast to what is seen clinically, male mice are resistant to antipsychotic-induced obesity. This is problematic as preclinical studies examining mechanisms of antipsychotic-induced metabolic dysfunction might be relevant to only half the popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a478184c8b1c7945076fef6dfb2f79
https://doi.org/10.1002/oby.23630
https://doi.org/10.1002/oby.23630
Publikováno v:
The Journal of Physiology. 600:2713-2728
Antipsychotic (AP) medications, such as olanzapine (OLZ), are used in the treatment of schizophrenia and a growing number of 'off-label' conditions. A single dose of OLZ causes robust increases in blood glucose within minutes of treatment. The purpos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638f5b300604671916f38bf920e78b93
https://doi.org/10.1113/jp282922
https://doi.org/10.1113/jp282922
Autor:
Hesham Shamshoum, Hana A. Dibe, Jibran Y. Khokhar, Greg L. McKie, David C. Wright, Hayley H. A. Thorpe, Christine A. Doucette, Kristin Hunt
Publikováno v:
The Journal of Physiology. 600:829-845
Key points Ambient cold exposure is often regarded as a promising anti-obesity treatment in mice. However, most preclinical studies aimed at treating obesity via cold-induced thermogenesis have been confounded by sub-thermoneutral housing temperature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171c8cccbe27165ca1acc9cb440c31fd
https://doi.org/10.1113/jp281774
https://doi.org/10.1113/jp281774
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(3)
Increasing whole-body energy expenditure via the pharmacological activation of uncoupling protein 1 (UCP1)-dependent brown adipose tissue (BAT) thermogenesis is a promising weight management strategy, yet most therapeutics studied in rodents to date
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1235838399e15a74675926f99541da53
https://pubmed.ncbi.nlm.nih.gov/35157333
https://pubmed.ncbi.nlm.nih.gov/35157333
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 132(2)
Growth differentiating factor-15 (GDF15) is expressed, and secreted, from a wide range of tissues and serves as a marker of cellular stress. A key transcriptional regulator of this hormone is the endoplasmic reticulum stress protein, CHOP (C/EBP homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f48858995b4cc715dbbb5a8206875
https://pubmed.ncbi.nlm.nih.gov/34913737
https://pubmed.ncbi.nlm.nih.gov/34913737
Autor:
Hesham Shamshoum, Logan K. Townsend, David C. Wright, Shivam Gandhi, Jane Shearer, David M. Mutch, Raylene A. Reimer, Sarah K. Trottier, Paul J. LeBlanc
Publikováno v:
Obesity. 28:97-105
Objective This study aimed to explore the individual and combined effects of skim milk powder (SMP) and exercise on indices of systemic and liver lipid metabolism in male obese rats. Methods Rats were fed a high-fat (~ 40% kcal from fat), high-sugar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb3584cab1db1eb82183aebb1c91a5d
https://doi.org/10.1002/oby.22621
https://doi.org/10.1002/oby.22621