Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hesham A. M. Gomaa"'
Autor:
Lamya H. Al-Wahaibi, Mohamed A. Mahmoud, Hayat Ali Alzahrani, Hesham A. Abou-Zied, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Stefan Bräse, Safwat M. Rabea
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
DNA gyrase and topoisomerase IV show great potential as targets for antibacterial medicines. In recent decades, various categories of small molecule inhibitors have been identified; however, none have been effective in the market. For the first time,
Externí odkaz:
https://doaj.org/article/77a587872e7447e5b0b9cecdeffb5087
Autor:
Muhammad Nasir Hayat Malik, Muhammad Nouman Tahir, Tariq G. Alsahli, Md. Mahedi Hassan Tusher, Sami I. Alzarea, Bader Alsuwayt, Shah Jahan, Hesham A. M. Gomaa, Mohamed E. Shaker, Muhammad Ali, Irfan Anjum, Muhammad Tariq Khan, Muhammad Roman, Ramla Shabbir
Publikováno v:
ACS Omega, Vol 8, Iss 40, Pp 37128-37139 (2023)
Externí odkaz:
https://doaj.org/article/e77f38e105fe45ab969e278ba0eaa3a6
Autor:
Fatma Fouad Hagar, Samar H. Abbas, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Ahmed M. Sayed, Dalia Abdelhamid, Mohamed Abdel-Aziz
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-22 (2023)
Abstract Introduction One of the most robust global challenges and difficulties in the 21st century is cancer. Treating cancer is a goal which continues to motivate researchers to innovate in design and development of new treatments to help battle th
Externí odkaz:
https://doaj.org/article/5e428929b5094e2197639356bc0f6092
Autor:
Mohamed E. Shaker, Hesham A. M. Gomaa, Sara H. Hazem, Mohamed A. Abdelgawad, Mohamed El-Mesery, Ahmed A. Shaaban
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/79ebe987326047009e88ba6cc2d179bd
Autor:
Mohamed E. Shaker, Hesham A. M. Gomaa, Sara H. Hazem, Mohamed A. Abdelgawad, Mohamed El-Mesery, Ahmed A. Shaaban
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The sterile inflammatory response mediated by Toll-like receptors (TLRs) 4 and 9 is implicated in the massive hepatic damage caused by acetaminophen (APAP)-overdose. There is a crosstalk between TLR-dependent signaling with other intracellular kinase
Externí odkaz:
https://doaj.org/article/7b33e56f892e467d8c3a98d0e36eeda3
Autor:
Alaa A. Hassan, Nasr K. Mohamed, Ashraf A. Aly, Mohamed Ramadan, Hesham A. M. Gomaa, Ahmed T. Abdel-Aziz, Bahaa G. M. Youssif, Stefan Bräse, Olaf Fuhr
Publikováno v:
Molecules, Vol 28, Iss 24, p 7951 (2023)
Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. There
Externí odkaz:
https://doaj.org/article/7feb057c741149129a88a88a7cb30fee
Autor:
Ashraf A. Aly, Mohammed B. Alshammari, Akil Ahmad, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Stefan Bräse, Mahmoud A. A. Ibrahim, Asmaa H. Mohamed
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104612- (2023)
In this article, we display on the synthesis and biological evaluation of a new series of thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the new compounds were confirmed by using different spectral techniques
Externí odkaz:
https://doaj.org/article/6f2d3d5650884a28a154186373f67503
Autor:
Essmat M. El-Sheref, Hendawy N. Tawfeek, Alaa A. Hassan, S. Bräse, Mohammed A. I. Elbastawesy, Hesham A. M. Gomaa, Yaser A. Mostafa, Bahaa G. M. Youssif
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Novel series of amidines were synthesized via the interaction between alicyclic amines, cyclic ketones, and a highly electrophilic 4-azidoquinolin-2(1H)-ones without any catalyst or additive. All the obtained products were elucidated based on NMR spe
Externí odkaz:
https://doaj.org/article/7838b914297c44ca8a909e8ba6e7764a
Autor:
Samar A. El-Kalyoubi, Hesham A. M. Gomaa, Elshimaa M. N. Abdelhafez, Mohamed Ramadan, Fatimah Agili, Bahaa G. M. Youssif
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 716 (2023)
The investigation of novel EGFR and BRAFV600E dual inhibitors is intended to serve as targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed and synthesized as EGFR/BRAFV600E dual inhibitors. The majority of the compo
Externí odkaz:
https://doaj.org/article/04089e050b4e41e8bbe9bf17f6281d12
Autor:
Omnia M. Hendawy, Mohammad M. Al-Sanea, Rehab Mohammed Elbargisy, Hidayat Ur Rahman, Hesham A. M. Gomaa, Ahmed A. B. Mohamed, Mohamed F. Ibrahim, Abdulsalam M. Kassem, Mohammed Elmowafy
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1124 (2023)
The objective of the current work was to fabricate, optimize and assess olive oil/phytosomal nanocarriers to improve quercetin skin delivery. Olive oil/phytosomal nanocarriers, prepared by a solvent evaporation/anti-solvent precipitation technique, w
Externí odkaz:
https://doaj.org/article/fa0062d3fb2b44889d9566cf250134b7