Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.

Autor: Schilling WHK; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Mukaka M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Callery JJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Llewelyn MJ; Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, United Kingdom.; Department of Microbiology and Infection, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom., Cruz CV; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Dhorda M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Ngernseng T; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Waithira N; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Ekkapongpisit M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Watson JA; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Chandna A; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia., Nelwan EJ; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.; Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Dr. Cipto Mangukusumo Hospital, Jakarta, Indonesia., Hamers RL; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Etyang A; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Beg MA; Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, Pakistan., Sow S; Centre pour le Développement des Vaccins (CVD-Mali), Bamako, Mali., Yavo W; Centre de Recherche et de Lutte contre le Paludisme, Institut National de Santé Publique, Abidjan, Côte d'Ivoire., Allabi AC; Faculty of Health Sciences, Laboratory of Pharmacology and Toxicology, University of Abomey-Calavi, Cotonou, Benin., Basnyat B; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit Nepal, Lalitpur, Nepal., Sharma SK; B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Amofa-Sekyi M; Zambart, University of Zambia School of Public Health, Lusaka, Zambia., Yonga P; Fountain Health Care Hospital, Fountain Projects and Research Office (FOPRO), Eldoret, Kenya., Adler A; Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Yuentrakul P; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Cope T; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Thaipadungpanit J; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Rienpradub P; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Imwong M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Abdad MY; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Blacksell SD; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Tarning J; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Goudjo FF; Coordination of Allada Ze Toffo Health Zone, Adjian, Benin., Dossou AD; National Public Health Laboratory, Cotonou, Benin., Konaté-Touré A; Centre de Recherche et de Lutte contre le Paludisme, Institut National de Santé Publique, Abidjan, Côte d'Ivoire., Assi SB; Institut Pierre Richet, Institut National de Santé, Publique, Bouaké, Côte d'Ivoire., Ouffoué K; Centre Hospitalier Universitaire (CHU) de Bouaké, Bouaké, Côte d'Ivoire., Nasronudin N; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Universitas Airlangga Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia., Rachman BE; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Universitas Airlangga Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia., Romadhon PZ; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Universitas Airlangga Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia., Dewanto DD; Husada Utama Hospital, Surabaya, Indonesia., Heryana MO; Husada Utama Hospital, Surabaya, Indonesia., Novi T; Husada Utama Hospital, Surabaya, Indonesia., Pasaribu AP; Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia., Mutiara M; Murni Teguh Hospital, Medan, Medan, Indonesia., Nasution MPR; Murni Teguh Hospital, Medan, Medan, Indonesia., Khairunnisa K; Murni Teguh Hospital, Medan, Medan, Indonesia., Dalimunthe FA; Faculty of Medicine, Universitas Sumatra Utara, Medan, Indonesia., Airlangga E; Bunda Thamrin Hospital, Medan, Indonesia., Fahrezzy A; Bunda Thamrin Hospital, Medan, Indonesia., Subronto Y; Department of Internal Medicine, Faculty of Medicine, Public Health And Nursing, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Indonesia., Ananda NR; Dr. Sardjito Hospital, Yogyakarta, Indonesia., Rahardjani M; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Rimainar A; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Lucinde RK; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Timbwa M; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Onyango OE; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Agutu C; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Akech S; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Hamaluba M; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Kipyego J; Fountain Health Care Hospital, Fountain Projects and Research Office (FOPRO), Eldoret, Kenya., Ngachi O; Fountain Health Care Hospital, Fountain Projects and Research Office (FOPRO), Eldoret, Kenya., Haidara FC; Centre pour le Développement des Vaccins (CVD-Mali), Bamako, Mali., Traoré OY; Centre pour le Développement des Vaccins (CVD-Mali), Bamako, Mali., Diarra F; Centre pour le Développement des Vaccins (CVD-Mali), Bamako, Mali., Khanal B; B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Dahal P; B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal., Shrestha S; Oxford University Clinical Research Unit Nepal, Lalitpur, Nepal., Rijal S; Oxford University Clinical Research Unit Nepal, Lalitpur, Nepal., Kabore Y; Epicentre, Niamey, Niger., Adehossi E; Université Abdou Moumouni de Niamey, Faculté des Science de la Santé, Niamey, Niger., Guindo O; Epicentre, Niamey, Niger., Qamar FN; Department of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan., Kazi AM; Department of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan., Woodrow CJ; Infectious Diseases Department, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.; University of Oxford, Medical Sciences Division, John Radcliffe Hospital, Oxford, United Kingdom., Laird S; University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, United Kingdom., Cheeba M; Zambart, University of Zambia School of Public Health, Lusaka, Zambia., Ayles H; Zambart, University of Zambia School of Public Health, Lusaka, Zambia.; Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom., Cheah PY; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Taylor WRJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Batty EM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Chotivanich K; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Pukrittayakamee S; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Phumratanaprapin W; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., von Seidlein L; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Dondorp A; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Day NPJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., White NJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Publikováno v: PLoS medicine [PLoS Med] 2024 Sep 12; Vol. 21 (9), pp. e1004428. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024).