Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hery Mitsutake"'
Autor:
Simone R. Castro, Lígia N. M. Ribeiro, Márcia C. Breitkreitz, Viviane A. Guilherme, Gustavo H. Rodrigues da Silva, Hery Mitsutake, Ana C. S. Alcântara, Fabiano Yokaichiya, Margareth K. K. D. Franco, Daniel Clemens, Ben Kent, Marcelo Lancellotti, Daniele R. de Araújo, Eneida de Paula
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC delivery at the site of injection, reducing such toxicit
Externí odkaz:
https://doaj.org/article/2a392a9650a24606a11c70d5ae2df5f8
Autor:
Fabiola Vieira de Carvalho, Ligia Nunes de Morais Ribeiro, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Hery Mitsutake, Talita Cesarim Mendonça, Gabriela Geronimo, Marcia Cristina Breitkreitz, Eneida de Paula
Publikováno v:
Molecules, Vol 27, Iss 24, p 8838 (2022)
Breast cancer is the neoplasia of highest incidence in women worldwide. Docetaxel (DTX), a taxoid used to treat breast cancer, is a BCS-class-IV compound (low oral bioavailability, solubility and intestinal permeability). Nanotechnological strategies
Externí odkaz:
https://doaj.org/article/86aa73d279f047ae9ebc89299cf77b15
Autor:
Hery Mitsutake, Gustavo H. Rodrigues da Silva, Márcia C. Breitkreitz, Eneida de Paula, Heloisa N. Bordallo
Publikováno v:
Mitsutake, H, da Silva, G H R, Breitkreitz, M C, de Paula, E & Bordallo, H N 2022, ' Neither too little nor too much : Finding the ideal proportion of excipients using confocal Raman and chemometrics ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 181, pp. 136-146 . https://doi.org/10.1016/j.ejpb.2022.11.008
The applications of Raman imaging in pharmaceutical field are ever-increasing due its ability to obtain spatial and spectral information simultaneously, once it allows determine the chemical distribution of compounds. In this sense, it is used to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11221c7005c9b0ce3d1ca06c23312bc4
https://curis.ku.dk/ws/files/337353330/1_s2.0_S0939641122002673_main.pdf
https://curis.ku.dk/ws/files/337353330/1_s2.0_S0939641122002673_main.pdf
Autor:
Hery Mitsutake, Gustavo Henrique Rodrigues da Silva, Márcia Cristina Breitkreitz, Eneida de Paula, Heloisa Nunes Bordallo
Excipient’s homogeneity is of paramount importance during the development of pharmaceutical formulations due to its relation to stability, safety and efficacy. A direct and unique approach to evaluate such property is 3D Raman imaging. This techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3a0dee51eac40e992d84649ef3c018
https://doi.org/10.26434/chemrxiv-2022-nq1wn-v2
https://doi.org/10.26434/chemrxiv-2022-nq1wn-v2
Autor:
Hery Mitsutake, Gustavo Henrique Rodrigues da Silva, Eneida de Paula, Márcia Cristina Breitkreitz
In nanostructured lipid carriers (NLC), the type and amount of excipients will determine API solubility and therefore the maximum drug load. Butamben is a topical local anesthetic which formulation in lipid-based DDS is difficult due to its affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22f4bb504b197a0e1b398b6e221e7364
https://doi.org/10.26434/chemrxiv-2022-5xrlm
https://doi.org/10.26434/chemrxiv-2022-5xrlm
Autor:
Ronei J. Poppi, Márcia Cristina Breitkreitz, Eneida de Paula, Hery Mitsutake, Gustavo Henrique Rodrigues da Silva, Lígia Nunes de Morais Ribeiro, Douglas N. Rutledge
Publikováno v:
Brazilian Journal of Analytical Chemistry. 8
Beeswaxes are interesting solid lipids for the development of nanostructured lipid carriers (NLC), and their origin can be either natural or synthetic. Due to this difference, their performance should be distinct and unstable formulations can be gene
Autor:
Ronei J. Poppi, Márcia Cristina Breitkreitz, Eneida de Paula, Hery Mitsutake, Lígia Nunes de Morais Ribeiro, Simone R. Castro, Gustavo Henrique Rodrigues da Silva
Publikováno v:
European Journal of Pharmaceutical Sciences. 135:51-59
Nanostructured lipid carriers (NLC) belong to youngest lipid-based nanocarrier class and they have gained increasing attention over the last ten years. NLCs are composed of a mixture of solid and liquid lipids, which solubilizes the active pharmaceut
Autor:
Márcia Cristina Breitkreitz, Marcelo Lancellotti, Gustavo Henrique Rodrigues da Silva, Daniel Clemens, Margareth K.K.D. Franco, Eneida de Paula, Ana C. S. Alcântara, Daniele Ribeiro de Araujo, Viviane A. Guilherme, Hery Mitsutake, Simone R. Castro, Lígia Nunes de Morais Ribeiro, Ben Kent, Fabiano Yokaichiya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Tetracaine TTC is a local anesthetic broadly used for topical and spinal blockade, despite its systemic toxicity. Encapsulation in nanostructured lipid carriers NLC may prolong TTC delivery at the site of injection, reducing such toxicity. This work
Autor:
Marina De Géa Neves, Ronei J. Poppi, Hery Mitsutake, Márcia Cristina Breitkreitz, Douglas N. Rutledge
Publikováno v:
Journal of Chemometrics
Journal of Chemometrics, Wiley, 2020, ⟨10.1002/cem.3288⟩
Journal of Chemometrics, Wiley, 2020, ⟨10.1002/cem.3288⟩
International audience; Solid dispersions are an interesting option to improve the solubility of Class II (high permeability, low water solubility) drugs of the Biopharmaceutical Classification System without the use of organic solvents. However, str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed481ffb8b7dcd46ea8b1a99d810b0b2
https://hal-agroparistech.archives-ouvertes.fr/hal-03040604
https://hal-agroparistech.archives-ouvertes.fr/hal-03040604