Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Herwin Daub"'
Publikováno v:
Molecules, Vol 24, Iss 16, p 2877 (2019)
Therapeutic and diagnostic nucleic acid aptamers are designed to bind tightly and specifically to their target. The combination of structural and kinetic analyses of aptamer interactions has gained increasing importance. Here, we present a fluorescen
Externí odkaz:
https://doaj.org/article/f4303dd246a34dc783739811072afbdb
Autor:
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Stefan C. Steinbacher, Agnieszka Sztyler, Gabriel Thieulin-Pardo, Tobias Neudegger, Nikolay V. Plotnikov, Ravi R. Iyer, Hilary A. Wilkinson, Edith Monteagudo, Dan P. Felsenfeld, Tasir S. Haque, Michael Finley, Celia Dominguez, Thomas F. Vogt, Brinda C. Prasad
Huntington’s disease (HD) is fatal neurodegenerative disorder caused by the expansion of a CAG-repeat tract in the huntingtin (HTT) gene. Human and mouse genetics studies have demonstrated a role for DNA mismatch repair (MMR) proteins which control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183b5ff9f85869d81d144088519fcbbf
https://doi.org/10.1101/2023.05.08.539930
https://doi.org/10.1101/2023.05.08.539930
Publikováno v:
Chembiochem
We have discovered the sirtuin‐rearranging ligands (SirReals) to be highly potent and selective inhibitors of the NAD+‐dependent lysine deacetylase Sirt2. Using a biotinylated SirReal in combination with biolayer interferometry, we previously obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79165649a6b52f0373176db443766937
https://mediatum.ub.tum.de/doc/1553967/document.pdf
https://mediatum.ub.tum.de/doc/1553967/document.pdf
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
The cytokine tumor necrosis factor-alpha (TNF-α) readily forms homotrimers at sub-nM concentrations to promote inflammation. For the treatment of inflammatory diseases with upregulated levels of TNF-α, a number of therapeutic antibodies are current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a69ee502168da1cc706d0ce95689528
https://mediatum.ub.tum.de/doc/1601995/document.pdf
https://mediatum.ub.tum.de/doc/1601995/document.pdf
Autor:
Herwin Daub, David Blocquel, Jiadong Zhou, Na Wei, Xiang-Lei Yang, Albena Jordanova, Maria-Luise Erfurth, Grace Kooi, Mathew Sajish, Ge Bai, Sheng Li, Paul Schimmel
Publikováno v:
Nucleic Acids Research
Nucleic acids research
Nucleic acids research
While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) disease suggests a common mechanism, a defect in enzymatic activity is not shared among the CMT-causing mutants. Protein misfolding is a common hypothesis underl
Recently, we have discovered the sirtuin rearranging ligands (SirReals) as a novel class of highly potent and selective inhibitors of the NAD+-dependent lysine deacetylase Sirt2. In previous studies, using a biotinylated SirReal analogue in combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f25ec051ae0e1aaab3a559ed05f3c7d
https://doi.org/10.26434/chemrxiv.9691730
https://doi.org/10.26434/chemrxiv.9691730
Publikováno v:
ChemBioChem. 21:1050-1050
Autor:
Dieter Heindl, Herwin Daub, Michael Schräml, Andreas Langer, Thomas W. Myers, Ulrich Rant, Ralf Strasser
Publikováno v:
Scientific Reports
The engineering of high-performance enzymes for future sequencing and PCR technologies as well as the development of many anticancer drugs requires a detailed analysis of DNA/RNA synthesis processes. However, due to the complex molecular interplay in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5052d51d09b1f5da84edb69eaffc6a
https://mediatum.ub.tum.de/1355488
https://mediatum.ub.tum.de/1355488