Výsledky vyhledávání - "Herve Duclohier"

Channel properties of template assembled alamethicin tetramers

Autor: Miroslaw T. Leplawy, G. M. Alder, Karol Kociolek, Herve Duclohier

Publikováno v: Journal of Peptide Science. 9:776-783

The multiple conductance levels displayed by the antibiotic alamethicin in planar lipid bilayers is explained by a dynamic ‘barrel-stave’ model, the conducting pore resulting from the aggregation of up to ten helical amphipathic helical monomers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975c8d12e8e7fe746aa3b335b6776829
https://doi.org/10.1002/psc.523

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Helical kink and channel behaviour: a comparative study with the peptaibols alamethicin, trichotoxin and antiamoebin

Autor: Herve Duclohier

Publikováno v: European biophysics journal : EBJ. 33(3)

Kinks or bends introduced in peptides and proteins by “helical distorter” residues such as proline, other imino acids and glycine, especially when these are in close proximity in the sequence, are increasingly recognized as playing an essential r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3464b002077b2cc3d5dc1244f41071d9
https://pubmed.ncbi.nlm.nih.gov/15014907

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How do channel- and pore-forming helical peptides interact with lipid membranes and how does this account for their antimicrobial activity?

Autor: Herve Duclohier

Publikováno v: Mini reviews in medicinal chemistry. 2(4)

Animals and plants defend themselves against pathogenic micro-organisms by the rapid mobilization of polycationic helical amphipathic peptides. Interactions with membranes induce optimal orientation and mutual structural changes, allowing for example

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e047411187ad76d67d6bbbe44945037c
https://pubmed.ncbi.nlm.nih.gov/12370054

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