In vivo methods for imaging blood–brain barrier function and dysfunction

Autor: William James Harris, Marie-Claude Asselin, Rainer Hinz, Laura Michelle Parkes, Stuart Allan, Ingo Schiessl, Herve Boutin, Ben Robert Dickie

Publikováno v: Harris, W J, Asselin, M-C, Hinz, R, Parkes, L M, Allan, S, Schiessl, I, Boutin, H & Dickie, B R 2022, ' In vivo methods for imaging blood–brain barrier function and dysfunction ', European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-022-05997-1

The blood–brain barrier (BBB) is the interface between the central nervous system and systemic circulation. It tightly regulates what enters and is removed from the brain parenchyma and is fundamental in maintaining brain homeostasis. Increasingly,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2211545529b8d9a0e899baffbe4741
https://doi.org/10.1007/s00259-022-05997-1

Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease

Autor: Oriana Mandolfo, Helen Parker, Èlia Aguado, Yuko Ishikawa Learmonth, Ai Yin Liao, Claire O’Leary, Stuart Ellison, Gabriella Forte, Jessica Taylor, Shaun Wood, Rachel Searle, Rebecca J Holley, Hervé Boutin, Brian W Bigger

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1579-1602 (2024)

Abstract Mucopolysaccharidosis type IIIA (MPS IIIA) is a rare paediatric lysosomal storage disorder, caused by the progressive accumulation of heparan sulphate, resulting in neurocognitive decline and behavioural abnormalities. Anecdotal reports from

Externí odkaz: https://doaj.org/article/6b33c2341e654421a1e1e4301ad75310

Establishing a Shared Imaging Research Infrastructure in the UK - A BioImagingUK White Paper

Autor: Aigbirhio, Franklin, Anderson, Kurt, Herve Boutin, Bruckbauer, Andreas, Collinson, Lucy, DeSouza, Nandita, Fletcher, Georgina, French, Paul, Jones, Martin, Kleywegt, Gerard, Marcello, Marco, Parsons, Maddy, Peckham, Michelle, Poptani, Harish, Sala, Evis, See, Violaine, Swedlow, Jason, Valli, Jessica, Verkade, Paul

A BioImagingUK White Paper based on a series of national consultations regarding potential UK Imaging Nodes within the EuroBioImaging-ERIC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2199c1ddb4fad5255586729c4d25f363

Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection

Autor: Yolanda Ohene, William J. Harris, Elizabeth Powell, Nina W. Wycech, Katherine F. Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B. Lawrence, Hervé Boutin, Geoff J. M. Parker, Laura M. Parkes, Ben R. Dickie

Publikováno v: Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-18 (2023)

Abstract Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in dementia which may be exacerbated by peripheral infection. Filter-exchange imaging (FEXI) is an

Externí odkaz: https://doaj.org/article/993f91b80b9647f1af20428f0e2b0cb2

Developmentautomation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Autor: Olivia, Morris, J, Gregory, M, Kadirvel, Fiona, Henderson, A, Blykers, Adam, McMahon, Mark, Taylor, David, Allsop, Stuart, Allan, J, Grigg, Herve, Boutin, Christian, Prenant

Publikováno v: Applied Radiation and Isotopes

2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4edb775782de0950b3d76885f23fcb1
https://pubmed.ncbi.nlm.nih.gov/27518217