Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Hervé Tiriac"'
Autor:
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetyla
Externí odkaz:
https://doaj.org/article/7cb7b07e6adf42b0aac1cff0935b9ca2
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Virneliz Fernandez-Vega, Shurong Hou, Dennis Plenker, Hervé Tiriac, Pierre Baillargeon, Justin Shumate, Louis Scampavia, Jan Seldin, Glauco R. Souza, David A. Tuveson, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 27, Iss 3, Pp 159-166 (2022)
Recent technological advances have enabled 3D tissue culture models for fast and affordable HTS. We are no longer bound to 2D models for anti-cancer agent discovery, and it is clear that 3D tumor models provide more predictive data for translation of
Externí odkaz:
https://doaj.org/article/dd3207bcac4340e9bc086866d293919b
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
Autor:
Tim D.D. Somerville, Yali Xu, Koji Miyabayashi, Hervé Tiriac, Cristian R. Cleary, Diogo Maia-Silva, Joseph P. Milazzo, David A. Tuveson, Christopher R. Vakoc
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1741-1755.e7 (2018)
Summary: The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the functional role of this putative transdifferentiation event in PDA pathogenesis remai
Externí odkaz:
https://doaj.org/article/e3a182a72aeb478b81b582108249c306
Autor:
Izumi C Mori, Yoshiyuki Murata, Yingzhen Yang, Shintaro Munemasa, Yong-Fei Wang, Shannon Andreoli, Hervé Tiriac, Jose M Alonso, Jeffery F Harper, Joseph R Ecker, June M Kwak, Julian I Schroeder
Publikováno v:
PLoS Biology, Vol 4, Iss 10, p e327 (2006)
Abscisic acid (ABA) signal transduction has been proposed to utilize cytosolic Ca(2+) in guard cell ion channel regulation. However, genetic mutants in Ca(2+) sensors that impair guard cell or plant ion channel signaling responses have not been ident
Externí odkaz:
https://doaj.org/article/31704b4eacd242c08a0e88ea66193fa4
Autor:
David A. Tuveson, Youngkyu Park, Steven Gallinger, Faiyaz Notta, Michael Wigler, Christopher R. Vakoc, Alexander Krasnitz, Jesse Gillis, Ralph H. Hruban, Laura D. Wood, Nicholas J. Roberts, Richard A. Burkhart, Chang-Il Hwang, Hervé Tiriac, Tim D.D. Somerville, Risa Karakida Kawaguchi, Gun Ho Jang, Jude Kendall, Siran Li, Pascal Belleau, Brinda Alagesan, Dennis Plenker, Giuseppina Caligiuri, Benno Traub, Astrid Deschênes, Lindsey A. Baker, Koji Miyabayashi
Comparison of IGO- and OGO-derived lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e1b6467d8820ad5f28ec9d99f4daa7
https://doi.org/10.1158/2159-8290.22536329.v1
https://doi.org/10.1158/2159-8290.22536329.v1
Autor:
David A. Tuveson, Youngkyu Park, Steven Gallinger, Faiyaz Notta, Michael Wigler, Christopher R. Vakoc, Alexander Krasnitz, Jesse Gillis, Ralph H. Hruban, Laura D. Wood, Nicholas J. Roberts, Richard A. Burkhart, Chang-Il Hwang, Hervé Tiriac, Tim D.D. Somerville, Risa Karakida Kawaguchi, Gun Ho Jang, Jude Kendall, Siran Li, Pascal Belleau, Brinda Alagesan, Dennis Plenker, Giuseppina Caligiuri, Benno Traub, Astrid Deschênes, Lindsey A. Baker, Koji Miyabayashi
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal common malignancy, with little improvement in patient outcomes over the past decades. Recently, subtypes of pancreatic cancer with different prognoses have been elaborated; however, the inabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e641bb063f9b6a5151db3b6cee472b0
https://doi.org/10.1158/2159-8290.c.6548099.v1
https://doi.org/10.1158/2159-8290.c.6548099.v1
Autor:
David A. Tuveson, Steven Gallinger, Alexander Krasnitz, Jennifer Knox, Richard Moffitt, Julie M. Wilson, Sandra E. Fischer, Benjamin Hubert, Christopher R. Vakoc, Ellen Li, Kenneth H. Yu, Christopher L. Wolfgang, Allyson Ocean, Craig Devoe, James M. Crawford, Edward Kim, Faiyaz Notta, Grainne M. O'Kane, Michael A. Hollingsworth, Jonathan R. Brody, Paul M. Grandgenett, Jonathan M. Buscaglia, Dominick J. DiMaio, Jean L. Grem, Phyllis A. Gimotty, Jordan M. Winter, James D. Sullivan, William Nealon, Divyesh V. Sejpal, Peter Allen, Juan Carlos Bucobo, Maoxin Wu, Joseph Kim, Aaron Sasson, Brian M. Wolpin, Andrew J. Aguirre, Elizabeth Thompson, Ralph H. Hruban, Laura D. Wood, Hans Clevers, Christine A. Iacobuzio-Donahue, Gokce Askan, Nicolas LeComte, Else Driehuis, Laura Martello, Cinthya Y. Lowder, Austin B. Goetz, Rashesh Sanghvi, Minita Shah, Nicolas Robine, Kanika Arora, Molly Johnson, Jasmine C. Huynh, Ammar A. Javed, Randze Lerie D. Palmaira, Joseph F. LaComb, Michelle Ma, Hardik Patel, C. Megan Young, Koji Miyabayashi, Gun-Ho Jang, Robert E. Denroche, Richard A. Burkhart, Fieke E. M. Froeling, Tim D. D. Somerville, Astrid Deschênes, Dennis Plenker, Dannielle D. Engle, Pascal Belleau, Hervé Tiriac
Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4b9db9fc893e295d2cada7f880c78f
https://doi.org/10.1158/2159-8290.22533064.v1
https://doi.org/10.1158/2159-8290.22533064.v1
Autor:
David A. Tuveson, Youngkyu Park, Steven Gallinger, Faiyaz Notta, Michael Wigler, Christopher R. Vakoc, Alexander Krasnitz, Jesse Gillis, Ralph H. Hruban, Laura D. Wood, Nicholas J. Roberts, Richard A. Burkhart, Chang-Il Hwang, Hervé Tiriac, Tim D.D. Somerville, Risa Karakida Kawaguchi, Gun Ho Jang, Jude Kendall, Siran Li, Pascal Belleau, Brinda Alagesan, Dennis Plenker, Giuseppina Caligiuri, Benno Traub, Astrid Deschênes, Lindsey A. Baker, Koji Miyabayashi
Confocal z-stack imaging of immunofluorescent (IF) images of mStrawberry-hT3 grafts 4 weeks after IGO transplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e03be949f36c1c5df071da46f2043f
https://doi.org/10.1158/2159-8290.22536287
https://doi.org/10.1158/2159-8290.22536287
Autor:
David A. Tuveson, Steven Gallinger, Alexander Krasnitz, Jennifer Knox, Richard Moffitt, Julie M. Wilson, Sandra E. Fischer, Benjamin Hubert, Christopher R. Vakoc, Ellen Li, Kenneth H. Yu, Christopher L. Wolfgang, Allyson Ocean, Craig Devoe, James M. Crawford, Edward Kim, Faiyaz Notta, Grainne M. O'Kane, Michael A. Hollingsworth, Jonathan R. Brody, Paul M. Grandgenett, Jonathan M. Buscaglia, Dominick J. DiMaio, Jean L. Grem, Phyllis A. Gimotty, Jordan M. Winter, James D. Sullivan, William Nealon, Divyesh V. Sejpal, Peter Allen, Juan Carlos Bucobo, Maoxin Wu, Joseph Kim, Aaron Sasson, Brian M. Wolpin, Andrew J. Aguirre, Elizabeth Thompson, Ralph H. Hruban, Laura D. Wood, Hans Clevers, Christine A. Iacobuzio-Donahue, Gokce Askan, Nicolas LeComte, Else Driehuis, Laura Martello, Cinthya Y. Lowder, Austin B. Goetz, Rashesh Sanghvi, Minita Shah, Nicolas Robine, Kanika Arora, Molly Johnson, Jasmine C. Huynh, Ammar A. Javed, Randze Lerie D. Palmaira, Joseph F. LaComb, Michelle Ma, Hardik Patel, C. Megan Young, Koji Miyabayashi, Gun-Ho Jang, Robert E. Denroche, Richard A. Burkhart, Fieke E. M. Froeling, Tim D. D. Somerville, Astrid Deschênes, Dennis Plenker, Dannielle D. Engle, Pascal Belleau, Hervé Tiriac
Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a90dd220ac0ec32817c28c76958ed3
https://doi.org/10.1158/2159-8290.22533052
https://doi.org/10.1158/2159-8290.22533052