Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hervé Seitz"'
Autor:
Élisabeth Houbron, Sophie Mockly, Sophia Rafasse, Nathalie Gros, Delphine Muriaux, Hervé Seitz
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 272-280 (2023)
RNA interference (RNAi) offers an efficient way to repress genes of interest, and it is widely used in research settings. Clinical applications emerged more recently, with 5 approved siRNAs (the RNA guides of the RNAi effector complex) against human
Externí odkaz:
https://doaj.org/article/92e2bdd2d7e847c691e930adad7d4420
Autor:
Jade Hebras, Virginie Marty, Jean Personnaz, Pascale Mercier, Nicolai Krogh, Henrik Nielsen, Marion Aguirrebengoa, Hervé Seitz, Jean-Phillipe Pradere, Bruno P Guiard, Jérôme Cavaille
Publikováno v:
eLife, Vol 9 (2020)
SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I RNA editing. Because SNORD115 genes are deleted in most patients with
Externí odkaz:
https://doaj.org/article/172b8ad4500f4e83a8a93161c4b6ee49
Autor:
Laurence Amar, Hervé Seitz
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/48d2db496c9d4846b6ea0753508fed0d
Autor:
Natalia Pinzón, Stéphanie Bertrand, Lucie Subirana, Isabelle Busseau, Hector Escrivá, Hervé Seitz
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007915 (2019)
RNA interference (RNAi) requires RNA-dependent RNA polymerases (RdRPs) in many eukaryotes, and RNAi amplification constitutes the only known function for eukaryotic RdRPs. Yet in animals, classical model organisms can elicit RNAi without possessing R
Externí odkaz:
https://doaj.org/article/3690983a6e75436191ccee4c9b1a6399
Autor:
Hélène Royo, Hervé Seitz, Elias ElInati, Antoine H F M Peters, Michael B Stadler, James M A Turner
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005461 (2015)
During the pachytene stage of meiosis in male mammals, the X and Y chromosomes are transcriptionally silenced by Meiotic Sex Chromosome Inactivation (MSCI). MSCI is conserved in therian mammals and is essential for normal male fertility. Transcriptom
Externí odkaz:
https://doaj.org/article/8cc5d14bf296465db956a49ab9f12121
* AbstractAssessment of the functionality of individual microRNA/target sites is a crucial issue. Genome editing techniques should theoretically permit a fine functional exploration of such interactions, allowing the mutation of microRNAs or individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c0a1207a765d02420f0255763f465d
https://doi.org/10.1101/2022.12.16.520740
https://doi.org/10.1101/2022.12.16.520740
Autor:
Élisabeth Houbron, Sophie Mockly, Sophia Rafasse, Nathalie Gros, Delphine Muriaux, Hervé Seitz
RNA interference (RNAi) offers an efficient way to repress genes of interest, and it is widely used in research settings. Clinical applications emerged more recently, with 5 approved siRNAs (the RNA guides of the RNAi effector complex) against human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f479d75d0c7eebfc3d5c0ba264e12d4f
https://doi.org/10.1101/2022.12.08.519651
https://doi.org/10.1101/2022.12.08.519651
Autor:
Sophie Mockly, Hervé Seitz
Publikováno v:
British journal of cancer.
A prolific scientific literature attributes pro- or anti-oncogenic properties to many human microRNAs ("miRNAs"). While many of these studies are based on unpersuasive analyses, one candidate suppressor tumour miRNA, miR-34a, appeared convincing enou
Publikováno v:
Nucleic acids research. 50(8)
While several microRNAs (miRNAs) have been proposed to act as tumor suppressors, a consensual definition of tumor suppressing miRNAs is still missing. Similarly to coding genes, we propose that tumor suppressor miRNAs must show evidence of genetic or
Autor:
Ulrike Rolle-Kampczyk, Hennicke Kamp, Wibke Busch, Jana Schor, Kristin Schubert, Hervé Seitz, Roland Buesen, Martin von Bergen, Sebastian Canzler, Jörg Hackermüller
Publikováno v:
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94, pp.371-388. ⟨10.1007/s00204-020-02656-y⟩
Archives of Toxicology, Springer Verlag, 2020, 94, pp.371-388. ⟨10.1007/s00204-020-02656-y⟩
Exposure of cells or organisms to chemicals can trigger a series of effects at the regulatory pathway level, which involve changes of levels, interactions, and feedback loops of biomolecules of different types. A single-omics technique, e.g., transcr