Toxicity assays in nanodrops combining bioassay and morphometric endpoints.

Autor: Frédéric Lemaire, Céline A Mandon, Julien Reboud, Alexandre Papine, Jesus Angulo, Hervé Pointu, Chantal Diaz-Latoud, Christian Lajaunie, François Chatelain, André-Patrick Arrigo, Béatrice Schaack

Publikováno v: PLoS ONE, Vol 2, Iss 1, p e163 (2007)

BACKGROUND: Improved chemical hazard management such as REACH policy objective as well as drug ADMETOX prediction, while limiting the extent of animal testing, requires the development of increasingly high throughput as well as highly pertinent in vi

Externí odkaz: https://doaj.org/article/972667f4ca95402ea57e3a917cd3dc4c

A 2.7-kb Portion of the 5′ Flanking Region of the Murine Glycoprotein αIIb Gene Is Transcriptionally Active in Primitive Hematopoietic Progenitor Cells

Autor: Valérie Roullot, Paquita Nurden, G Marguerie, Diana Tronik-Le Roux, Muriel Vernet, Hervé Pointu, Philippe Tropel, Christel Poujol

Publikováno v: Blood. 90:2995-3004

The continuous generation of mature blood cells from primitive multipotent progenitor cells requires a highly complex series of cellular events that are still largely unknown. To examine the molecular events associated with the commitment of these he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51fa1f6d6bb2c4315ea4178a80262141
https://doi.org/10.1182/blood.v90.8.2995

A vital role of tubulin-tyrosine-ligase for neuronal organization

Autor: Yasmina Saoudi, Annie Andrieux, Muriel Vernet, Paul A. Salin, Christophe Bosc, Hervé Pointu, Achim D. Gruber, Didier Job, Annie Schweitzer, Claire Meissirel, Juergen Wehland, Christian Erck, Leticia Peris

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2005, 102 (22), pp.7853-7858. ⟨10.1073/pnas.0409626102⟩
Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (22), pp.7853-8. ⟨10.1073/pnas.0409626102⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2005, 102 (22), pp.7853-8. ⟨10.1073/pnas.0409626102⟩

http://www.pnas.org/content/102/22/7853.long; International audience; Tubulin is subject to a special cycle of detyrosination/tyrosination in which the C-terminal tyrosine of alpha-tubulin is cyclically removed by a carboxypeptidase and readded by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75deed47b5c95209893f1151e276e5e1
https://hal.archives-ouvertes.fr/hal-03398970

Disruption of the Regulatory β Subunit of Protein Kinase CK2 in Mice Leads to a Cell-Autonomous Defect and Early Embryonic Lethality

Autor: Thierry Buchou, Hervé Pointu, Hans H. Jensen, Birgitte Brinkmann Olsen, Muriel Vernet, Claude Cochet, Brigitte Boldyreff, Olaf-Georg Issinger, Olivier Blond

Publikováno v: Buchou, T, Vernet, M, Blond, O, Jensen, H H, Pointu, H, Olsen, B B, Cochet, C, Issinger, O-G & Boldyreff, B 2003, ' Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality ', Molecular and Cellular Biology, vol. 23, no. 3, pp. 908-915 . https://doi.org/10.1128/MCB.23.3.908-915.2003

Udgivelsesdato: 2003-Feb Protein kinase CK2 is a ubiquitous protein kinase implicated in proliferation and cell survival. Its regulatory beta subunit, CK2beta, which is encoded by a single gene in mammals, has been suspected of regulating other prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfbc09b45271a70bfb93f14f2926ecd
https://europepmc.org/articles/PMC140710/

Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits

Autor: Wilfried Dalemans, Marie-Georges Stinnakre, Huguette Schultz, Rainer Bischoff, Hervé Pointu, Daniel Clesse, Joe Attal, M. Massoud, Andrea Pavirani, Louis-Marie Houdebine

Publikováno v: J.Biotechnol., 18(3), 193-203
Journal of Biotechnology
Journal of Biotechnology, Elsevier, 1991, 18, pp.193-204

A DNA construct containing the human alpha 1-antitrypsin gene including 1.5 and 4 kb of 5' and 3' flanking sequences, was microinjected into the pronucleus of rabbit embryos. The recombinant human protein was (a) expressed in the blood circulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b09008366e11b7cfd70392386869c02
https://research.rug.nl/en/publications/62939b3e-ec6b-4da5-9ff3-2d29cc5c7828