Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hervé Lebrec"'
Autor:
Cris Kamperschroer, Brendon Frank, Caroline Genell, Hervé Lebrec, Shermaine Mitchell-Ryan, Brigitte Molinier, Courtni Newsome, Marie-Soleil Piche, Daniel Weinstock, Mark Collinge, Wendy Freebern, Daniel Rubio
Publikováno v:
Journal of Immunotoxicology, Vol 20, Iss 1 (2023)
AbstractCytotoxic T-lymphocytes (CTL) are a subset of T-cells that play a critical role in protecting against intracellular infections and cancer, and have the ability to identify and kill infected or transformed cells expressing non-self peptides as
Externí odkaz:
https://doaj.org/article/e52be90ce9a64f71b5de2941c8e295cf
Publikováno v:
Journal of Immunotoxicology, Vol 19, Iss 1, Pp 109-116 (2022)
The potential for effector functions of therapeutic antibodies, including antibody-dependent cell-mediated cytotoxicity (ADCC), is a biological activity of interest for characterization, regardless of if ADCC is an intended primary pharmacological ef
Externí odkaz:
https://doaj.org/article/9f657dbea76a49e2b12de3ca8be1a202
Publikováno v:
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 154-162 (2021)
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of in vitro and in vivo immunophenotyping and functional study endpoints in pre-clinical studies. CD8+ cytotoxic T-lymphocyte (CTL) activity im
Externí odkaz:
https://doaj.org/article/e0ce9dcc7d614ab5b9780e895fd53896
Autor:
Cris Kamperschroer, Jacintha Shenton, Hervé Lebrec, John K. Leighton, Paul A. Moore, Oliver Thomas
Publikováno v:
Journal of Immunotoxicology, Vol 17, Iss 1, Pp 67-85 (2020)
Currently, there is a multitude of CD3 bispecifics with different molecular designs and binding properties in preclinical and clinical development for the treatment of liquid or solid tumors. The key safety concerns with CD3 bispecifics are excessive
Externí odkaz:
https://doaj.org/article/9b9d19fabbc749bc85340c7759626998
Autor:
Brendon Frank, Yu-Ling Wei, Kyung-Hoon Kim, Abraham Guerrero, Hervé Lebrec, Mercedesz Balazs, Xiaoting Wang
Publikováno v:
Journal of Immunotoxicology, Vol 15, Iss 1, Pp 119-125 (2018)
The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. While the functional assessment of CD8+ cytotoxic T-lymphocytes (CTL) is well-characterized in the clinic, the lack o
Externí odkaz:
https://doaj.org/article/0d61cdca2da642319ce676710d9aa3e1
Autor:
Tod Harper, Amy Sharma, Sarav Kaliyaperumal, Flordeliza Fajardo, Katie Hsu, Lily Liu, Rhian Davies, Yu-Ling Wei, Jinghui Zhan, Juan Estrada, Majk Kvesic, Lisa Nahrwold, Wibke Deisting, Marc Panzer, Keegan Cooke, Hervé Lebrec, Olivier Nolan-Stevaux
Publikováno v:
Toxicological Sciences. 189:32-50
Bispecific T-cell engager (BiTE) molecules have great potential to treat cancer. Nevertheless, dependent on the targeted tumor antigen, the mechanism of action that drives efficacy may also contribute to on-target/off-tumor toxicities. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774f0bed25671619c33c61ea448cae63
https://doi.org/10.1093/toxsci/kfac052
https://doi.org/10.1093/toxsci/kfac052
Publikováno v:
Toxicology. 158:25-29
T lymphocytes can be characterized by their pattern of cytokine secretion and be divided into type I (Th(l)/Tc(l)) and type 2 (Th(2)/Tc(2)) subsets. The involvement of type-1 or type 2-like responses in sensitization has been studied in the mouse, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9317f9b2c1dced53fb1bfb700a8280
https://doi.org/10.1016/s0300-483x(00)00398-x
https://doi.org/10.1016/s0300-483x(00)00398-x
Publikováno v:
Methods. 19:36-47
Generation of immunity is a highly complex process in which proliferation and differentiation of immune-competent cells regulated by cytokines and cell-cell interactions play a major role. Reducing the number of immune-competent cells or altering the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2551403efc3c24aefe4d1d1dadc0cb63
https://doi.org/10.1006/meth.1999.0825
https://doi.org/10.1006/meth.1999.0825
Autor:
J. Laurent, N. Bachot, Saadia Kerdine, Marc Pallardy, I. Gaspard, Hervé Lebrec, M.T. Guinnepain
Publikováno v:
Cell Biology and Toxicology. 15:57-62
Allergic contact dermatitis is induced by a wide variety of drugs that trigger specific immune responses following topical exposure. Identified chemical stuctures involved in such reactions include the mercuric and thiosalicylic acid groups of thimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84dde05f7c0ee11ade1d78fce91de94c
https://doi.org/10.1023/a:1007554707345
https://doi.org/10.1023/a:1007554707345
Publikováno v:
Toxicology Letters. :257-260
Developing a battery of immune function assays to screen potential immunotoxic compounds has been a major issue these past years. Improving this approach is possible using new probes and parameters that are now available from recent knowledge on how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cffcffdfd34097036a5c85461c532c7
https://doi.org/10.1016/s0378-4274(98)00315-4
https://doi.org/10.1016/s0378-4274(98)00315-4