Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hervé Le Hir"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Exon junction complexes are deposited at exon-exon junctions during splicing. They are primarily known to activate non-sense mediated degradation of transcripts harbouring premature stop codons before the last intron. According to a popular
Externí odkaz:
https://doaj.org/article/eb506b0106574aa39cf9510ab3b313e6
Autor:
Lucía Morillo, Toni Paternina, Quentin Alasseur, Auguste Genovesio, Schraga Schwartz, Hervé Le Hir
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background The exon junction complex (EJC) is involved in most steps of the mRNA life cycle, ranging from splicing to nonsense-mediated mRNA decay (NMD). It is assembled by the splicing machinery onto mRNA in a sequence-independent manner. A
Externí odkaz:
https://doaj.org/article/0ce3172e8f834f9a9715476d07ff94bf
Autor:
Oh Sung Kwon, Rahul Mishra, Adham Safieddine, Emeline Coleno, Quentin Alasseur, Marion Faucourt, Isabelle Barbosa, Edouard Bertrand, Nathalie Spassky, Hervé Le Hir
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Exon junction complexes (EJCs) that mark untranslated mRNA are involved in transport, translation and nonsense-mediated mRNA decay. Here the authors show centrosomal localization of EJCs which appears to be required for both the localization of NIN m
Externí odkaz:
https://doaj.org/article/1d82ac1f9eec446e9d08f2e30f0c1cab
Autor:
Adham Safieddine, Emeline Coleno, Soha Salloum, Arthur Imbert, Abdel-Meneem Traboulsi, Oh Sung Kwon, Frederic Lionneton, Virginie Georget, Marie-Cécile Robert, Thierry Gostan, Charles-Henri Lecellier, Racha Chouaib, Xavier Pichon, Hervé Le Hir, Kazem Zibara, Florian Mueller, Thomas Walter, Marion Peter, Edouard Bertrand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Centrosomes function as microtubule organizing centers where several mRNAs accumulate. By employing high-throughput single molecule FISH screening, the authors discover that 8 human mRNAs localize to centrosomes with unique cell cycle dependent patte
Externí odkaz:
https://doaj.org/article/25ad29dc528349468528a16fc452a6aa
Autor:
Mathieu Bahin, Benoit F. Noël, Valentine Murigneux, Charles Bernard, Leila Bastianelli, Hervé Le Hir, Alice Lebreton, Auguste Genovesio
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background The last 10 years have seen the rise of countless functional genomics studies based on Next-Generation Sequencing (NGS). In the vast majority of cases, whatever the species, whatever the experiment, the two first steps of data ana
Externí odkaz:
https://doaj.org/article/c11072d8abec4b54b238ce8d6fed01fc
Autor:
Joanne Kanaan, Saurabh Raj, Laurence Decourty, Cosmin Saveanu, Vincent Croquette, Hervé Le Hir
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
UPF1 is a highly processive helicase that plays an essential role in nonsense-mediated mRNA decay. Here the authors use single molecule binding assays to establish a functionally important relationship between helicase grip to nucleic acids, binding
Externí odkaz:
https://doaj.org/article/85ab4400a2f146e49bce2617f7651da0
Autor:
Francesca Fiorini, Jean-Philippe Robin, Joanne Kanaan, Malgorzata Borowiak, Vincent Croquette, Hervé Le Hir, Pierre Jalinot, Vincent Mocquet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translo
Externí odkaz:
https://doaj.org/article/cee99c9cf6b9423fa0e3aee0a205c4f9
Autor:
Nejc Haberman, Ina Huppertz, Jan Attig, Julian König, Zhen Wang, Christian Hauer, Matthias W. Hentze, Andreas E. Kulozik, Hervé Le Hir, Tomaž Curk, Christopher R. Sibley, Kathi Zarnack, Jernej Ule
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/8bb830280be149adbf06245c00271dd6
Autor:
Nadia, Ruiz-Gutierrez, Martin, Rieu, Jimmy, Ouellet, Jean-François, Allemand, Vincent, Croquette, Hervé, Le Hir
Publikováno v:
Methods in enzymology. 673
Helicases form a universal family of molecular motors that bind and translocate onto nucleic acids. They are involved in essentially every aspect of nucleic acid metabolism: from DNA replication to RNA decay, and thus ensure a large spectrum of funct
Autor:
Anna Uzonyi, David Dierks, Ronit Nir, Oh Sung Kwon, Ursula Toth, Isabelle Barbosa, Cindy Burel, Alexander Brandis, Walter Rossmanith, Hervé Le Hir, Boris Slobodin, Schraga Schwartz
Publikováno v:
Molecular cell.
N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-uniformly distributed across the transcriptome, yet the basis for its selective deposition is unknown. Here, we propose that m6A deposition is not selective. Instead, it is exc