Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons

Autor: Laurie Verzeaux, Nicolas Belloy, Jessica Thevenard-Devy, Jérôme Devy, Géraldine Ferracci, Laurent Martiny, Stéphane Dedieu, Manuel Dauchez, Hervé Emonard, Nicolas Etique, Emmanuelle Devarenne-Charpentier

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects. We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this

Externí odkaz: https://doaj.org/article/16e3c09a1b4d4103a912523a3d0bd5d9

Endogenous sphingomyelin segregates into submicrometric domains in the living erythrocyte membrane[S]

Autor: Mélanie Carquin, Hélène Pollet, Maria Veiga-da-Cunha, Antoine Cominelli, Patrick Van Der Smissen, Francisca N'kuli, Hervé Emonard, Patrick Henriet, Hideaki Mizuno, Pierre J. Courtoy, Donatienne Tyteca

Publikováno v: Journal of Lipid Research, Vol 55, Iss 7, Pp 1331-1342 (2014)

We recently reported that trace insertion of exogenous fluorescent (green BODIPY) analogs of sphingomyelin (SM) into living red blood cells (RBCs), partially spread onto coverslips, labels submicrometric domains, visible by confocal microscopy. We he

Externí odkaz: https://doaj.org/article/52724f4fde7a4b589052dbd7d0888a92

LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways.

Autor: Benoit Langlois, Gwenn Perrot, Christophe Schneider, Patrick Henriet, Hervé Emonard, Laurent Martiny, Stéphane Dedieu

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11584 (2010)

BACKGROUND: The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic receptor mediating the clearance of various extracellular molecules involved in the dissemination of cancer cells. LRP-1 thus appeared as an attractive recepto

Externí odkaz: https://doaj.org/article/053ebe74adfd44d8b5d4ea8969e18b79

Identification of LRP-1 as an endocytosis and recycling receptor for B1-integrin in thyroid cancer cells

Autor: Theret, Louis, Jeanne, Albin, Langlois, Benoît, Hachet, Cathy, David, Marion, Khrestchatisky, Michel, Devy, Jérome, Hervé, Emonard, Almagro, Sébastien, Dedieu, Stéphane

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2017, 8 (45), pp.78614-78632. ⟨10.18632/oncotarget.20201⟩
Oncotarget, 2017, 8 (45), pp.78614-78632. ⟨10.18632/oncotarget.20201⟩

International audience; LRP-1 is a large endocytic receptor mediating the clearance of various molecules from the extracellular matrix. LRP-1 was reported to control focal adhesion turnover to optimize the adhesion-deadhesion balance to support invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::41fcc1e8a78db3926f3a5b05b8f28452
https://hal.univ-reims.fr/hal-02184520

Class III Phosphoinositide 3-Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling

Autor: Giuseppina Grieco, Bart Vanhaesebroeck, Virginie Janssens, Hervé Emonard, Sarah Carpentier, Donatienne Tyteca, Christophe E. Pierreux, Héloïse P. Gaide Chevronnay, Patrick Van Der Smissen, Francisca N'Kuli, Benoit Bilanges, Pierre J. Courtoy

Publikováno v: Traffic. 14:933-948

Recycling is a limiting step for receptor-mediated endocytosis. We first report three in vitro or in vivo evidences that class III PI3K/VPS34 is the key PI3K isoform regulating apical recycling. A substractive approach, comparing in Opossum Kidney (O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5141edd9180e164da4b558589c1dd53e
https://doi.org/10.1111/tra.12079