Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hervé Coste"'
Autor:
Hervé Coste, Marie-Hélène Fouchet, Frédéric Donche, Sylvie Demaria Magny, Florent Potvain, M Walker, Marc Issandou, Nerina Dodic, Anne-Benedicte Boullay, Anne Marie Jeanne Bouillot, Christophe Junot, Christelle Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6218-6232
We describe the discovery of novel potent inhibitors of 2,3-oxidosqualene:lanosterol cyclase inhibitors (OSCi) from a focused pharmacophore-based screen. Optimization of the most tractable hits gave a series of compounds showing inhibition of cholest
Autor:
Alain Claude-Marie Daugan, Francois Hyafil, Jorge Kirilovsky, Hervé Coste, Anne-Charlotte de Gouville, Cécile Ruault, Richard Frederic Labaudiniere, Pascal Grondin
Publikováno v:
Journal of Medicinal Chemistry. 46:4525-4532
Starting from ethyl beta-carboline-3-carboxylate (beta-CCE), 1, a modest inhibitor of type 5 phosphodiesterase (PDE5), a series of functionalized tetrahydro-beta-carboline derivatives has been identified as a novel chemical class of potent and select
Autor:
Hervé Coste, Joan C. Rodríguez
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Apolipoprotein CIII (apoCIII) plays an important role in plasma triglyceride and remnant lipoprotein metabolism. Because hypertriglyceridemia is an independent risk factor in coronary artery disease and the presence in plasma of triglyceride-rich rem
Publikováno v:
British Journal of Pharmacology. 119:471-478
1. In rat aortic rings precontracted with phenylephrine, the beta-adrenoceptor agonist isoprenaline (10 nM to 30 microM) produces greater relaxant effects in preparations with endothelium than in endothelium-denuded preparations. The aim of this stud
Autor:
Pascal Grondin, Hervé Coste
Publikováno v:
Biochemical Pharmacology. 50:1577-1585
Guanosine cyclic 3':5'-monophosphate (cGMP) plays a crucial role in regulating vascular smooth muscle contractile state. In rat aortic smooth muscle cells (RSMC) three isozymes of phosphodiesterase (PDE) may be involved in the degradation of cGMP, na
Autor:
Rab K. Prinjha, Helen R. Flynn, Stephen A. Hughes, Jérôme Toum, Rachel Grimley, Chun-wa Chung, Sandrine Martin, Jean-Marie Brusq, Hervé Coste, Kevin Lee, Chris J. Delves, Alizon M. Riou, Romain Luc Marie Gosmini, Catherine A. Clément, Edwige Nicodeme, Anne Marie Jeanne Bouillot, Eric Boursier, Robert Woodward, Anne-Benedicte Boullay, Olivier Mirguet, Jorge Kirilovsky, Paul Homes, Jonathan I. Wilde, Paul Bamborough, Iain Uings, Julia H. White, Françoise Gellibert, Emma J. Jones, Florence Blandel, Sylvie M. Magny
Publikováno v:
Journal of medicinal chemistry. 54(11)
Epigenetic mechanisms of gene regulation have a profound role in normal development and disease processes. An integral part of this mechanism occurs through lysine acetylation of histone tails which are recognized by bromodomains. While the biologica
Autor:
Julia H. White, Charles M. Rice, Rab K. Prinjha, Scott Dewell, Alexander Tarakhovsky, Chun-wa Chung, Jose M. Lora, Edwige Nicodeme, Paul A. Wilson, Kate L. Jeffrey, Kevin Lee, Hervé Coste, Uwe Schaefer, Jorge Kirilovsky, Rohit Chandwani, Ivan Marazzi, Soren Beinke
Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune defence, is frequently deleterious to the host due to the exaggerated production of inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36b5d8b7a2823a5891d224401ebd732
https://europepmc.org/articles/PMC5415086/
https://europepmc.org/articles/PMC5415086/
Publikováno v:
ChemInform. 26
Publikováno v:
Lipids
Lipids, Springer Verlag, 1992, pp.331-338
Lipids, Springer Verlag, 1992, pp.331-338
Twelve analogs of 1,2-di-O-octanoylglycerol modified at C-3 and three quaternaryN-alkyl-ammonium derivatives of glycerol were synthesized. The compounds were testedin vitro as potential modulators of the calcium activated, phospholipid dependent prot
Autor:
Joan C. Rodríguez, Frank G. Schaap, Thierry Huby, Hervé Coste, M. John Chapman, Xavier Prieur
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of biological chemistry, 280(30), 27533-27543. American Society for Biochemistry and Molecular Biology Inc.
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Journal of biological chemistry, 280(30), 27533-27543. American Society for Biochemistry and Molecular Biology Inc.
Recercat. Dipósit de la Recerca de Catalunya
instname
The apolipoprotein AV gene (APOA5) is a key determinant of plasma triglyceride levels, a major risk factor for coronary artery disease and a biomarker for the metabolic syndrome. Since thyroid hormones influence very low density lipoprotein triglycer