Výsledky vyhledávání - "Hervé Castel"

Akademický článek

Impact of web application support versus standard management on adherence with adjuvant hormone therapy in patients treated for breast cancer: the WEBAPPAC study

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)

Abstract Background Non-metastatic breast cancer treatment is mainly based on surgery, with or without chemotherapy, radiotherapy and/or hormone therapy. To reduce the risk of hormone receptor positive (HR+) disease recurrence, hormone therapy is pre

Externí odkaz: https://doaj.org/article/26a7a9b19d2643669b2a86b963b0dcee

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Akademický článek

Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms

Autor: Mathias Cacquevel, Séverine Launay, Hervé Castel, Karim Benchenane, Simon Chéenne, Luc Buée, Lieve Moons, André Delacourte, Peter Carmeliet, Denis Vivien

Publikováno v: Neurobiology of Disease, Vol 27, Iss 2, Pp 164-173 (2007)

Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder in the ageing population. It is characterized by the cerebral accumulation of toxic amyloid-beta peptide assemblies (Aβ). The serine protease plasmin, which is generate

Externí odkaz: https://doaj.org/article/b61b20fef58f42a6ace8881c926512a7

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Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms

Autor: Denis Vivien, Karim Benchenane, Hervé Castel, Simon Chéenne, Peter Carmeliet, Séverine Launay, André Delacourte, Luc Buée, Lieve Moons, Mathias Cacquevel

Publikováno v: Neurobiology of Disease, Vol 27, Iss 2, Pp 164-173 (2007)

Alzheimer's disease (AD) is the most common form of neurodegenerative disorder in the ageing population. It is characterized by the cerebral accumulation of toxic amyloid-beta peptide assemblies (Abeta). The serine protease plasmin, which is generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddafbc0582221e53be892ccfa93e7902
https://doi.org/10.1016/j.nbd.2007.04.004

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Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory

Autor: Hervé Castel, Omar Touzani, Denis Vivien, Eric Maubert, Karim Benchenane, Carine Ali, François Dauphin, Véronique Agin, Michel Boulouard, Robert Dantzer, José P. López-Atalaya, Sabrina Butt-Gueulle, Benoit D. Roussel, R. M. Bluthe, Mónica Fernández-Monreal

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2007, 120 (Pt 4), pp.578-85. 〈10.1242/jcs.03354〉
Journal of Cell Science, Company of Biologists, 2007, 120 (Pt 4), pp.578-585. ⟨10.1242/jcs.03354⟩

International audience; Fine-tuning of NMDA glutamatergic receptor signalling strategically controls crucial brain functions. This process depends on several ligands and modulators, one of which unexpectedly includes the serine protease tissue-type p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607a15d8b363effd0f2fd5547248dee3
https://doi.org/10.1242/jcs.03354

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Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact

Autor: Richard Macrez, Yannick Hommet, Véronique Agin, Luce Dauphinot, Benoit D. Roussel, Joan Montaner, Marie-Claude Potier, Amandine Jullienne, Eric Maubert, Carine Ali, Laurent Plawinski, Manuel Yepes, Hervé Castel, Denis Vivien, Josep Munuera

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2009, 132 (Pt 8), pp.2219-30. ⟨10.1093/brain/awp162⟩
Brain-A Journal of Neurology, 2009, 132 (Pt 8), pp.2219-30. ⟨10.1093/brain/awp162⟩
BRAIN
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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International audience; Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcd68cf6bb32f57fe44d89f97e8e3b0
https://www.hal.inserm.fr/inserm-01296806/document

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Toward Safer Thrombolytic Agents in Stroke: Molecular Requirements for NMDA Receptor-Mediated Neurotoxicity

Autor: Ronan Bureau, Denis Vivien, José P. López-Atalaya, Jana Sopkova-de Oliveira Santos, Benoit D. Roussel, Hervé Castel, Karl-Uwe Petersen, Jérôme Parcq, Carine Ali, Karim Benchenane, Denis Levrat, Sylvain Rault, Hubert Vaudry, Olivier Nicole, Jérôme Leprince, Yannick Hommet, Denis To Van

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2008, 28 (6), pp.1212-1221. ⟨10.1038/jcbfm.2008.14⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Cerebral Blood Flow and Metabolism, 2008, 28 (6), pp.1212-1221. ⟨10.1038/jcbfm.2008.14⟩

Current thrombolytic therapy for acute ischemic stroke with tissue-type plasminogen activator (tPA) has clear global benefits. Nevertheless, evidences argue that in addition to its prohemorrhagic effect, tPA might enhance excitotoxic necrosis. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2d4101465d6aebe55fdd4a1b52d984
https://hal-normandie-univ.archives-ouvertes.fr/hal-01972984

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Desmoteplase (DSPA) does not interact with or cleave the NMDA receptor NR1 subunit: Possible molecular basis for improved tolerability in treatment of acute ischemic stroke

Autor: Karl-Uwe Petersen, Karim Benchenane, Denis Vivien, Carine Ali, José Lopez Atalaya, Hervé Castel

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 25:S578-S578

Over the last decade, tissue type plasminogen activator (tPA) has been implicated in a variety of brain functions. It is secreted from growth cones or extending neurites, modulates neurite outgrowth and promotes neuronal migration in vitro. tPA has a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::218ba0dee44c662a3e6041619fb80761
https://doi.org/10.1038/sj.jcbfm.9591524.0578

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Physiological and pathological implications of the tPA/NR1 interaction: An immunization-based investigation

Autor: Carine Ali, Robert Dantzer, Hervé Castel, Omar Touzani, Denis Vivien, Mónica Fernández-Monreal, Eric T. MacKenzie, Michel Boulouard, Karim Benchenane, François Dauphin, José P. López-Atalaya, R. M. Bluthe

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 25:S579-S579

Tissue-type plasminogen activator (tPA) is thought to be involved in several brain functions and dysfunctions. Its vascular thrombolytic activity led to its use for ischemic stroke treatment. However, increasing evidence suggests that tPA potentiates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4be163475dcb527b006cd7b920ee7843
https://doi.org/10.1038/sj.jcbfm.9591524.0579

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