Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains

Autor: Stefano Marullo, Mark G. H. Scott, Hervé Enslen, Mathieu Coureuil

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

More than 12 years have passed since the seminal observation that meningococcus, a pathogen causing epidemic meningitis in humans, occasionally associated with infectious vasculitis and septic shock, can promote the translocation of β-arrestins to t

Externí odkaz: https://doaj.org/article/629dc2d8f3c5418c913fe97e5ace516d

The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis

Autor: Stephane Angers, Kusumika Saha, Jane E. Findlay, Evelyne Lima-Fernandes, Michel Bouvier, Justine S. Paradis, Stefano Marullo, Cédric Auffray, George S. Baillie, Hervé Enslen, Mark G.H. Scott, Alessia Zamborlini, Anne Poupon, Elodie Blondel-Tepaz, Badr Sokrat, Milena Kosic, Louis Gaboury, Marie Leverve

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2021, 40 (12), pp.2243-2257. ⟨10.1038/s41388-021-01704-w⟩
Oncogene, 2021, 40 (12), pp.2243-2257. ⟨10.1038/s41388-021-01704-w⟩

International audience; Mdm2 antagonizes the tumor suppressor p53. Targeting the Mdm2-p53 interaction represents an attractive approach for the treatment of cancers with functional p53. Investigating mechanisms underlying Mdm2-p53 regulation is there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adce6552ce02dc0e61877eaf3db50f5
https://doi.org/10.1038/s41388-021-01704-w

Beta-arrestins operate an on/off control switch for focal adhesion kinase activity

Autor: Stefano Marullo, Aurélie Borrull, Mireille Lambert, Isaure Lot, Alexandre Beautrait, Michel Bouvier, Revu Ann Alexander, Kusumika Saha, Eleonore Decosta, Mark G.H. Scott, Atef Asnacios, Hervé Enslen, Guillaume Abadie, Hiroyuki Kobayashi

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2020, 77 (24), pp.5259-5279. ⟨10.1007/s00018-020-03471-5⟩
Cellular and Molecular Life Sciences, Springer Verlag, 2020, Epub ahead of print. ⟨10.1007/s00018-020-03471-5⟩
Cellular and Molecular Life Sciences, 2020, Epub ahead of print. ⟨10.1007/s00018-020-03471-5⟩

International audience; Focal adhesion kinase (FAK) regulates key biological processes downstream of G protein-coupled receptors (GPCRs) in normal and cancer cells, but the modes of kinase activation by these receptors remain unclear. We report that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343d1ead466b69d230fa38200280fb6a
https://hal.archives-ouvertes.fr/hal-03031947

Methods to Characterize Protein Interactions with β-Arrestin In Cellulo

Autor: Revu Ann, Alexander, Isaure, Lot, Hervé, Enslen

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1957

β-Arrestins 1 and 2 (β-arr1 and β-arr2) are ubiquitous proteins with common and distinct functions. They were initially identified as proteins recruited to stimulated G protein-coupled receptors (GPCRs), regulating their desensitization and intern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94102417899af89bb8fa7f63c9099a17
https://pubmed.ncbi.nlm.nih.gov/30919352

GABAB receptor cell surface export is controlled by an endoplasmic reticulum gatekeeper

Autor: Michèle Darmon, Robert Gardette, Gabriel Gäta, Liliana Pardo-López, Lamia Achour, Seung-Kwon Yang, Stefano Marullo, M.B. Emerit, Stéphane Doly, Vincent Armand, Manuel Mameli, Hamasseh Shirvani, Hervé Enslen, Bernhard Bettler, Martin Gassmann, Bruno Giros, Frank J. Meye

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2016, 21, pp.480-490. ⟨10.1038/mp.2015.72⟩
Molecular Psychiatry, Nature Publishing Group, 2016, 21 (4), pp.480-490. ⟨10.1038/mp.2015.72⟩
Molecular Psychiatry, 2016, 21, pp.480-490. ⟨10.1038/mp.2015.72⟩
Molecular psychiatry
Molecular Psychiatry, 2016, 21 (4), pp.480-490. ⟨10.1038/mp.2015.72⟩
Molecular Psychiatry, Nature Publishing Group, 2016, 21, pp.480-490. 〈10.1038/mp.2015.72〉

International audience; Endoplasmic reticulum (ER) release and cell-surface export of many G protein-coupled receptors (GPCRs) are tightly regulated. For gamma-aminobutyric acid (GABA) B receptors of GABA, the major mammalian inhibitory neurotransmit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d68bd455c628ef799bf8b87262121a5
https://www.hal.inserm.fr/inserm-01153352/document