Scribble1/AP2 Complex Coordinates NMDA Receptor Endocytic Recycling

Autor: Nicolas H. Piguel, Sabine Fievre, Jean-Michel Blanc, Mario Carta, Maïté M. Moreau, Enora Moutin, Vera L. Pinheiro, Chantal Medina, Jerome Ezan, Léa Lasvaux, François Loll, Christelle M. Durand, Kai Chang, Ronald S. Petralia, Robert J. Wenthold, F. Anne Stephenson, Laurent Vuillard, Hervé Darbon, Julie Perroy, Christophe Mulle, Mireille Montcouquiol, Claudia Racca, Nathalie Sans

Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 712-727 (2014)

The appropriate trafficking of glutamate receptors to synapses is crucial for basic synaptic function and synaptic plasticity. It is now accepted that NMDA receptors (NMDARs) internalize and are recycled at the plasma membrane but also exchange betwe

Externí odkaz: https://doaj.org/article/8f27d3fd857744fca1150bb04ae3b89b

Lebetin Peptides, A New Class of Potent Platelet Aggregation Inhibitors: Chemical Synthesis, Biological Activity and NMR Spectroscopic Study

Autor: Ernest Giralt, Ameur Cherif, Pascal Mansuelle, Naziha Marrakchi, Soumaya Kouidhi, Didier Gigmes, Amor Mosbah, Hervé Darbon, Gaëtan Herbette, Kamel Mabrouk, Mohamed El Ayeb

Publikováno v: International Journal of Peptide Research and Therapeutics. 26:21-31

Platelets have a well-established role in atherosclerosis and related diseases. Lebetins from the venom of Vipera lebetina, lacking the RGD sequence, emerged as a new family of platelet aggregation inhibitors. However, the interaction sites and preci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af7e4fe1aead54bcb5ba0a7757630f60
https://doi.org/10.1007/s10989-019-09812-8

High-Throughput Production of Oxidized Animal Toxins in Escherichia coli

Autor: Yoan, Duhoo, Ana Filipa, Sequeira, Natalie J, Saez, Jeremy, Turchetto, Laurie, Ramond, Fanny, Peysson, Joana L A, Brás, Nicolas, Gilles, Hervé, Darbon, Carlos M G A, Fontes, Renaud, Vincentelli

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2025

High-throughput production (HTP) of synthetic genes is becoming an important tool to explore the biological function of the extensive genomic and meta-genomic information currently available from various sources. One such source is animal venom, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26f752cd75b276290aaf3f459b10e279
https://pubmed.ncbi.nlm.nih.gov/31267452

In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide

Autor: Yao Dong, Michel De Waard, Lucie Dardevet, Michel Ronjat, Franck C. Chatelain, Florian Lesage, Isaac N. Pessah, Wei Feng, Sawsan Al Khoury, Virginie Vialla, Hervé Darbon, Samir Chahboun

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (17), pp.E2460-E2468. ⟨10.1073/pnas.1517342113⟩
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 17
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (17), pp.E2460-E2468. ⟨10.1073/pnas.1517342113⟩

International audience; The venom peptide maurocalcin (MCa) is atypical among toxins because of its ability to rapidly translocate into cells and potently activate the intracellular calcium channel type 1 ryanodine receptor (RyR1). Therefore, MCa is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca6607603bc57fa9fefaaea6c0a5db1
https://hal.archives-ouvertes.fr/hal-02390413

Insecticidal peptides from the theraposid spider Brachypelma albiceps: An NMR-based model of Ba2

Autor: Jan Tytgat, Cédric Bernard, Herlinda Clement, Frank Bosmans, Elba Villegas, Hervé Darbon, Lourival D. Possani, Alejandro Alagón, Gerardo Corzo

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1794:1190-1196

Soluble venom and purified fractions of the theraposid spider Brachypelma albiceps were screened for insecticidal peptides based on toxicity to crickets. Two insecticidal peptides, named Ba1 and Ba2, were obtained after the soluble venom was separate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3095c84d368f2b4d6bb91e1c5de42e2d
https://doi.org/10.1016/j.bbapap.2009.04.004