Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hervé, Barjat"'
Autor:
Amin Farshchi, Hervé Barjat, Stephen Checkley, Michael Leane, Mike Tobyn, Chris Morris, Furqan Tahir, Richard Anthony Storey, John F. Gamble, Toma Chitu, Neil Dawson, Andy Mitchell, Ana Patricia Ferreira, Kendal Pitt
Publikováno v:
Journal of Pharmaceutical Innovation. 16:181-196
Understanding and predicting the flow of bulk pharmaceutical materials could be key in enabling pharmaceutical manufacturing by continuous direct compression (CDC). This study examines whether, by taking powder and bulk measurements, and using statis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5934f75aee0af4cfdec854ab8551253b
https://doi.org/10.1007/s12247-020-09433-5
https://doi.org/10.1007/s12247-020-09433-5
Autor:
Valerie S. Honndorf, Holger Schmidt, Hans F. Wehrl, Stefan Wiehr, Walter Ehrlichmann, Leticia Quintanilla-Martinez, Hervé Barjat, Sally-Ann Ricketts, Bernd J. Pichler
Publikováno v:
Molecular Imaging, Vol 14 (2015)
We aimed to quantitatively characterize the treatment effects of docetaxel in the HCT116 xenograft mouse model, applying diffusion-weighted magnetic resonance imaging (MRI) and positron emission tomography (PET) using 2-deoxy-2-[ 18 F]fluoro-D-glucos
Externí odkaz:
https://doaj.org/article/3b92a51d10184c80a7fbcfaa7a9761fc
Autor:
Ross A, Little, Hervé, Barjat, Jennifer I, Hare, Mary, Jenner, Yvonne, Watson, Susan, Cheung, Katherine, Holliday, Weijuan, Zhang, James P B, O'Connor, Simon T, Barry, Sanyogitta, Puri, Geoffrey J M, Parker, John C, Waterton
Publikováno v:
Magnetic resonance imaging. 46
Solid tumours exhibit enhanced vessel permeability and fenestrated endothelium to varying degree, but it is unknown how this varies in patients between and within tumour types. Dynamic contrast-enhanced (DCE) MRI provides a measure of perfusion and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21be2c6f767c3cdf38b2f50534260ee0
https://pubmed.ncbi.nlm.nih.gov/29154898
https://pubmed.ncbi.nlm.nih.gov/29154898
Autor:
Hervé Barjat, Urszula M. Polanska, Alison Pritchard, Sally-Ann Emmas, Kevin Hudson, Juliana Maynard, François-Xavier Blé, Urs Hancox, Emily Lawrie
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183048 (2017)
PLoS ONE
PLoS ONE
Background The phosphatidyl inositol 3 kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) signal transduction pathway is frequently de-regulated and activated in human cancer and is an important therapeutic target. AZD8835 is a PI3K inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548441491c6d17128ee282a1e90d6883
http://europepmc.org/articles/PMC5555689?pdf=render
http://europepmc.org/articles/PMC5555689?pdf=render
Publikováno v:
In Chemical Physics Letters 1999 305(1):28-34
Autor:
Neil Woodhouse, Katherine F. Holliday, Susan Cheung, Hervé Barjat, James P B O'Connor, Marietta Scott, Josephine H. Naish, J.L. Ulloa, Gerard Thompson, Geoff J M Parker, Giovanni A Buonaccorsi, Inna V. Linnik, Timothy H Ward, Caroline Dive, Alan Jackson, John C. Waterton, Cassandra L Hodgkinson, Samantha J. Mills, Carsten Liess, Helen Young, Darren L. Roberts
Publikováno v:
Magnetic Resonance in Medicine. 71:1854-1862
PURPOSE: There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e34aa9b6fb8836d17d017093845be1c
https://doi.org/10.1002/mrm.24826
https://doi.org/10.1002/mrm.24826
Autor:
Simon T. Barry, François-Xavier Blé, Emily Lawrie, Sally-Ann Emmas, Urs Hancox, Hervé Barjat, Deborah Oakes, Juliana Maynard, Urszula M. Polanska
Publikováno v:
EJNMMI Research
Background The phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising therapeutic target. AZD8186 (AstraZeneca) is a PI3Kβ/δ inhibitor, currently in phase 1 clinical trials. 18F-fluorodeoxygluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1969a504db1cfe092bffe23eab6786ab
https://doi.org/10.1186/s13550-016-0220-9
https://doi.org/10.1186/s13550-016-0220-9
Autor:
Michael F. James, Simon T. Bate, Satheesh Maheswaran, Andreas Pohlmann, Derek L. G. Hill, Daniel Rueckert, Lorna Tilling, Sean C. Smart, Neil Upton, David R. Howlett, Jo Hajnal, Thomas Hartkens, Hervé Barjat, Jill C. Richardson
Publikováno v:
Brain Research. 1270:19-32
In humans, mutations of amyloid precursor protein (APP) and presenilins (PS) 1 and 2 are associated with amyloid deposition, brain structural change and cognitive decline, like in Alzheimer's disease (AD). Mice expressing these proteins have illumina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f980b09100744c9d1b6bbc293cbc183c
https://doi.org/10.1016/j.brainres.2009.02.045
https://doi.org/10.1016/j.brainres.2009.02.045
Autor:
Bernd J. Pichler, Valerie S. Honndorf, Hervé Barjat, Holger Schmidt, Hans F. Wehrl, Anke Stahlschmidt, Leticia Quintanilla-Martinez, Stefan Wiehr, Sally-Ann Emmas
Publikováno v:
Molecular imaging and biology. 18(2)
Positron emission tomography (PET) and diffusion-weighted MRI (DW-MRI) were used to characterize the treatment effects of the MEK1/2 inhibitor selumetinib (AZD6244), docetaxel, and their combination in HCT116 tumor-bearing mice on the molecular level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82d09b5b205cc56cd8b7b6895a55edc
https://pubmed.ncbi.nlm.nih.gov/26276154
https://pubmed.ncbi.nlm.nih.gov/26276154
Autor:
Valerie S, Honndorf, Holger, Schmidt, Hans F, Wehrl, Stefan, Wiehr, Walter, Ehrlichmann, Leticia, Quintanilla-Martinez, Hervé, Barjat, Sally-Ann, Ricketts, Bernd J, Pichler
Publikováno v:
Molecular imaging. 13
We aimed to quantitatively characterize the treatment effects of docetaxel in the HCT116 xenograft mouse model, applying diffusion-weighted magnetic resonance imaging (MRI) and positron emission tomography (PET) using 2-deoxy-2-[¹⁸F]fluoro-d-gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ac7b42d45b59d31f6b4c92532c74c6d
https://pubmed.ncbi.nlm.nih.gov/25430886
https://pubmed.ncbi.nlm.nih.gov/25430886