Inducing novel endosymbioses by implanting bacteria in fungi.

Autor: Giger GH; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Ernst C; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Richter I; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena, Germany., Gassler T; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Field CM; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Sintsova A; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Kiefer P; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Gäbelein CG; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland.; Whitehead Institute, Cambridge, MA, USA., Guillaume-Gentil O; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Scherlach K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena, Germany., Bortfeld-Miller M; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Zambelli T; Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland., Sunagawa S; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Künzler M; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland., Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena, Germany.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany., Vorholt JA; Institute of Microbiology, Department of Biology, ETH Zurich, Zurich, Switzerland. jvorholt@ethz.ch.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8038), pp. 415-422. Date of Electronic Publication: 2024 Oct 02.

Beneficial Soil Fungus Kills Predatory Nematodes with Dehydropeptides Translocating into the Animal Gut.

Autor: Büttner H; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstraße 11a, 07745 Jena, Germany., Rassbach J; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstraße 11a, 07745 Jena, Germany.; Institute of Pharmacy, Pharmaceutical Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany., Schultz C; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI), 07745 Jena, Germany., Popp J; Institute of Physical Chemistry (IPC) and Abbe Center of Photonics (ACP), Member of the Leibniz Center for Photonics in Infection Research (LPI), Friedrich Schiller University Jena, 07743 Jena, Germany.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, 07743 Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Health Technologies, Member of the Leibniz Center for Photonics in Infection Research (LPI), 07745 Jena, Germany., Gressler M; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstraße 11a, 07745 Jena, Germany.; Institute of Pharmacy, Pharmaceutical Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany., Hertweck C; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstraße 11a, 07745 Jena, Germany.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, 07743 Jena, Germany.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, Friedrich Schiller University Jena, 07743 Jena, Germany.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Dec 18; Vol. 146 (50), pp. 34702-34710. Date of Electronic Publication: 2024 Dec 09.

A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.

Autor: Schaefer S; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia.; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia.; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Vij R; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Sprague JL; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Austermeier S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Dinh H; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia., Judzewitsch PR; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia., Müller-Loennies S; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany., Lopes Silva T; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Seemann E; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany., Qualmann B; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany., Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany.; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany., Scherlach K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Gutsmann T; Division of Biophysics, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.; Centre for Structural Systems Biology (CSSB), Hamburg, Germany., Cain AK; ARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, North Ryde, NSW, Australia., Corrigan N; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia., Gresnigt MS; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany.; Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Boyer C; School of Chemical Engineering, University of New South Wales (UNSW), Sydney, NSW, Australia. cboyer@unsw.edu.au.; Australian Centre for NanoMedicine, UNSW, Sydney, NSW, Australia. cboyer@unsw.edu.au., Lenardon MD; School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia. m.lenardon@unsw.edu.au., Brunke S; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany. sascha.brunke@leibniz-hki.de.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 09; Vol. 15 (1), pp. 6818. Date of Electronic Publication: 2024 Aug 09.

An Enzymatic Prodrug-like Route to Thio and Selenoamides.

Autor: Ishida K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany., Litomska A; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany., Dunbar KL; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany., Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.; Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743, Jena, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jul 29; Vol. 63 (31), pp. e202404243. Date of Electronic Publication: 2024 Jun 27.

Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis.

Autor: Roman D; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany.; Anti-Infectives from Microbiota Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany., Meisinger P; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany.; Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany., Guillonneau R; Nantes Université, CNRS, US2B, UMR 6286, F-44000, Nantes, France., Peng CC; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany.; Anti-Infectives from Microbiota Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany., Peltner LK; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy-, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany., Jordan PM; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy-, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany., Haensch V; Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany., Götze S; Anti-Infectives from Microbiota Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany., Werz O; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy-, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany., Hertweck C; Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany.; Institute of Microbiology-, Friedrich-Schiller-University Jena, 07743, Jena, Germany., Chen Y; School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, United Kingdom., Beemelmanns C; Chemical Biology of Microbe-Host Interactions, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11 A, 07745, Jena, Germany.; Anti-Infectives from Microbiota Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) Campus E8.1, 66123, Saarbrücken, Germany.; Saarland University, Campus E8.1, 66123, Saarbrücken, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jun 03; Vol. 63 (23), pp. e202401195. Date of Electronic Publication: 2024 Apr 29.