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of 10
pro vyhledávání: '"Hershna Patel"'
Autor:
Mohammed Saqif Ahmad, Maria Braoudaki, Hershna Patel, Irshad Ahmad, Shagufta, Shoib Sarwar Siddiqui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule inhibitors targeting Siglec-15
Externí odkaz:
https://doaj.org/article/fe8095863a714a81aed1e8991ed7ed9e
Autor:
Hershna Patel, Andreas Kukol
Publikováno v:
Drug Discovery Today. 26:503-510
Since the discovery of the anti-influenza drugs oseltamivir and zanamivir using computer-aided drug design methods, there have been significant applications of molecular modelling methodologies applied to influenza A virus drug discovery, such as mol
Autor:
Hershna Patel, Andreas Kukol
Publikováno v:
Virology. 537:97-103
The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein sequences and molecular modelling of full-length
Autor:
Hershna Patel, David B. Whitehouse
Publikováno v:
Molecular Biology and Biotechnology ISBN: 9781788017862
Proteomics is the large-scale and high-throughput study of proteins. A proteome is the population of all proteins expressed by the genome in a specific cell type, tissue or biological fluid at a particular time and under specific conditions. It is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef5d11aae9ade47ffc60a9d13b6c62f9
https://doi.org/10.1039/9781788017862-00123
https://doi.org/10.1039/9781788017862-00123
Autor:
Peter Laslo, David G. Kent, Edwin Chen, Joanna Baxter, Jeanne F Rivera, Hershna Patel, Emma L Burman, Sally A Boxall, Brian R. Jackson, Ann Mullally, Grace Boyd, Rachael Smyth, Ghadah Alameer, April Joy Baral, Anthony R. Green, Fatima Nadat
Publikováno v:
Blood Adv
Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALRdel52) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88bd78a01d6c569428b7041878c47a
https://www.repository.cam.ac.uk/handle/1810/319699
https://www.repository.cam.ac.uk/handle/1810/319699
Autor:
Hershna Patel, David B. Whitehouse
Publikováno v:
Genomics and Clinical Diagnostics ISBN: 9781782628217
Proteomics is the large-scale and high-throughput study of proteins. A proteome is the population of all proteins expressed by the genome in a specific cell type, tissue or biological fluid at a particular time and under specific conditions. Any tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f06eb5dfe218253f0bbd3b5948e1e1b
https://doi.org/10.1039/9781782628217-00103
https://doi.org/10.1039/9781782628217-00103
Autor:
Hershna Patel, Andreas Kukol
Publikováno v:
Virology. 509
The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the PB2 protein sequen
Autor:
Hershna Patel, Andreas Kukol
Publikováno v:
Journal of Negative Results in Biomedicine
Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets. This report shows the development and evaluation of a novel yet straightforward attempt to improve
Autor:
Andreas Kukol, Hershna Patel
Publikováno v:
Biochemical Society transactions. 44(3)
Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are
Autor:
Andreas Kukol, Hershna Patel
Publikováno v:
Future Virology. 9:625-627
This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2