Výsledky vyhledávání - "Hershel H. Lackey"

Evaluating the effect of ionic strength on PNA:DNA duplex formation kinetics†

Autor: Eric M. Peterson, Joel M. Harris, Colin Swenson, Jennifer M. Heemstra, Hershel H. Lackey, Eric J. Reece

Publikováno v: RSC Chemical Biology

Peptide nucleic acid (PNA) is a unique synthetic nucleic acid analog that has been adopted for use in many biological applications. These applications rely upon the robust Franklin–Watson–Crick base pairing provided by PNA, particularly at lower

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bc34f48ffca0e32bb404ab886f56eb
http://europepmc.org/articles/PMC8341200

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Thermostability Trends of TNA:DNA Duplexes Reveal Strong Purine Dependence

Autor: Jennifer M. Heemstra, Eric M. Peterson, Zhe Chen, Joel M. Harris, Hershel H. Lackey

Publikováno v: ACS Synthetic Biology. 8:1144-1152

The development of high fidelity polymerases and streamlined synthesis of threose nucleic acid (TNA) triphosphates and phosphoramidites has made TNA accessible as a motif for generating nuclease-resistant high-affinity aptamers, antisense oligos, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6203f0d2be76c5099aac74a2ca5c5778
https://doi.org/10.1021/acssynbio.9b00028

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Probing the Mechanism of Structure-Switching Aptamer Assembly by Super-Resolution Localization of Individual DNA Molecules

Autor: Joel M. Harris, Hershel H. Lackey, Eric M. Peterson, Jennifer M. Heemstra

Publikováno v: Analytical chemistry. 92(10)

Oligonucleotide aptamers can be converted into structure-switching biosensors by incorporating a short, typically labeled oligonucleotide that is complementary to the analyte-binding region. Binding of a target analyte can disrupt the hybridization e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc4cb0e20c27b866e84b0c2cacccb54
https://pubmed.ncbi.nlm.nih.gov/32297506

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Single-Molecule Kinetics Show DNA Pyrimidine Content Strongly Affects RNA:DNA and TNA:DNA Heteroduplex Dissociation Rates

Autor: Eric M. Peterson, Hershel H. Lackey, Joel M. Harris, Jennifer M. Heemstra, Zhe Chen

Publikováno v: ACS synthetic biology. 9(2)

The heteroduplex hybridization thermodynamics of DNA with either RNA or TNA are greatly affected by DNA pyrimidine content, where increased DNA pyrimidine content leads to significantly increased duplex stability. Little is known, however, about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf94b1afa15a2a2017b3343208ea7121
https://pubmed.ncbi.nlm.nih.gov/31909980

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DNA/TNA mesoscopic modeling of melting temperatures suggests weaker hydrogen bonding of CG than in DNA/RNA

Autor: Maria Izabel Muniz, Jennifer M. Heemstra, Hershel H. Lackey, Gerald Weber

Publikováno v: Chemical Physics Letters. 749:137413

TNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-type helices and a strong dependency of their thermodynamic properties on purine/pyrimidine ratio. However, unlike RNA/DNA, not much is known about the base-pair pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15b21d96fe3bcdd6f2bec99228665d4e
https://doi.org/10.1016/j.cplett.2020.137413

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Stereoconvergent Synthesis of Chiral Allylboronates from an E/Z Mixture of Allylic Aryl Ethers Using a 6-NHC−Cu(I) Catalyst

Autor: Hershel H. Lackey, Jin Kyoon Park, Brian A. Ondrusek, D. Tyler McQuade

Publikováno v: Journal of the American Chemical Society. 133:2410-2413

We present a 6-NHC-Cu(I) complex that provides α-substituted allylboronates using allylic aryl ether substrates. The method was discovered by comparison of the chemoselectivities exhibited by complexes 1a, 1b, 2, and 3. We observed that 1a preferent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be93e9a8c4500db8bef7edac1e3de9ea
https://doi.org/10.1021/ja1112518

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A Chiral 6-Membered N-Heterocyclic Carbene Copper(I) Complex That Induces High Stereoselectivity

Autor: Kirill Kovnir, Michael Shatruk, D. Tyler McQuade, Jin Kyoon Park, Matthew D. Rexford, Hershel H. Lackey

Publikováno v: Organic Letters. 12:5008-5011

A chiral 6-membered annulated N-heterocyclic (6-NHC) copper complex that catalyzes β-borylations with high yield and enantioselectivity was developed. The chiral 6-NHC copper complex is easy to prepare on the gram scale and is very active, showing 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8b771dea9a562f2987263dabcbb16c
https://doi.org/10.1021/ol1021756

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ChemInform Abstract: Stereoconvergent Synthesis of Chiral Allylboronates from an E/Z Mixture of Allylic Aryl Ethers Using a 6-NHC-Cu(II) Catalyst

Autor: Jin Kyoon Park, Brian A. Ondrusek, D. Tyler McQuade, Hershel H. Lackey

Publikováno v: ChemInform. 42

The six-membered N-heterocyclic carbene-copper complex IQC catalyzes the asymmetric borylation of both the (E)- and (Z)-isomer of an allylic m-nitrophenyl ether to give the α-substituted allylboronate with the same absolute configuration.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f489c9cab85cf708792073835962c4aa
https://doi.org/10.1002/chin.201128175

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Rigid and Flexible Pavement Aircraft Tie-Downs

Autor: Hershel H. Lackey, Athar Saeed, Michael I Hammons, Christopher J. Jackson

This report details a three phase project focusing on aircraft tie-downs, which describe mechanisms designed to secure aircraft to the pavement surface. The objective of this project was to determine the pull-out capacity of existing tie-downs and to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1507c6aba7d79d8265b3bef872a69425
https://doi.org/10.21236/ada545866

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