An Interscholastic Network To Generate LexA Enhancer Trap Lines in Drosophila

Autor: Lutz Kockel, Catherine Griffin, Yaseen Ahmed, Lauren Fidelak, Arjun Rajan, Ethan P. Gould, Myles Haigney, Benjamin Ralston, Rex J. Tercek, Lara Galligani, Sagar Rao, Lutfi Huq, Hersh K. Bhargava, Ailis C. Dooner, Emily G. Lemmerman, Ruby F. Malusa, Tran H. Nguyen, Julie S. Chung, Sara M. Gregory, Kiyomasa M. Kuwana, Jonathan T. Regenold, Alexander Wei, Jake Ashton, Patrick Dickinson, Kate Martel, Connie Cai, Carissa Chen, Stephen Price, Jeffrey Qiao, David Shepley, Joanna Zhang, Meghana Chalasani, Khanh Nguyen, August Aalto, ByungJun Kim, Erik Tazawa-Goodchild, Amanda Sherwood, Ahmad Rahman, Sum Ying Celeste Wu, Joel Lotzkar, Serena Michaels, Hillary Aristotle, Antigone Clark, Grace Gasper, Evan Xiang, Frieda Luna Schlör, Melissa Lu, Kate Haering, Julia Friberg, Alyssa Kuwana, Jonathan Lee, Alan Liu, Emma Norton, Leena Hamad, Clara Lee, Dara Okeremi, Harry diTullio, Kat Dumoulin, Sun Yu Gordon Chi, Grayson S. Derossi, Rose E. Horowitch, Elias C. Issa, Dan T. Le, Bryce C. Morales, Ayush Noori, Justin Shao, Sophia Cho, Mai N. Hoang, Ian M. Johnson, Katherine C. Lee, Maria Lee, Elizabeth A. Madamidola, Katrina E. Schmitt, Gabriel Byan, Taeyoung Park, Jonathan Chen, Alexi Monovoukas, Madison J. Kang, Tanner McGowan, Joseph J. Walewski, Brennan Simon, Sophia J. Zu, Gregory P. Miller, Kate B. Fitzpatrick, Nicole Lantz, Elizabeth Fox, Jeanette Collette, Richard Kurtz, Chris Duncan, Ryan Palmer, Cheryl Rotondo, Eric Janicki, Townley Chisholm, Anne Rankin, Sangbin Park, Seung K. Kim

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2097-2106 (2019)

Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology, and physiology. However, the number of well-defined LexA enhancer trap insertions

Externí odkaz: https://doaj.org/article/fc21fc9a2ebf49d9b04f204517e30bf7

Data from Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients

Autor: Anant Madabhushi, Priti Lal, Michael Feldman, Timothy R. Rebbeck, Brian D. Robinson, Francesca Khani, Kosj Yamoah, Pingfu Fu, Sanjay Gupta, Jon Whitney, Andrew Janowczyk, Robin Elliott, Patrick Leo, Hersh K. Bhargava

Purpose:Between 30%–40% of patients with prostate cancer experience disease recurrence following radical prostatectomy. Existing clinical models for recurrence risk prediction do not account for population-based variation in the tumor phenotype, de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bcbb40049c50e45904b35156864d28
https://doi.org/10.1158/1078-0432.c.6530166

Synthetic cytokine circuits that drive T cells into immune-excluded tumors

Autor: Greg M. Allen, Nicholas W. Frankel, Nishith R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim

Publikováno v: Science (New York, N.Y.), vol 378, iss 6625

Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03660310665c60ac0266b16fa87e9d43
https://pubmed.ncbi.nlm.nih.gov/36520915

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The HaloTag as a general scaffold for far-red tunable chemigenetic indicators

Autor: Adam J. Berro, Natalie Falco, Luke D. Lavis, Hersh K. Bhargava, Benjamien Moeyaert, Mariam Chupanova, Eric R. Schreiter, Claire Deo, Ahmed S. Abdelfattah, Helen Farrants

Publikováno v: Nature Chemical Biology. 17:718-723

Functional imaging using fluorescent indicators has revolutionized biology, but additional sensor scaffolds are needed to access properties such as bright, far-red emission. Here, we introduce a new platform for 'chemigenetic' fluorescent indicators,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63fc84bd80ffa91b35774d1e6556f767
https://doi.org/10.1038/s41589-021-00775-w