Trial protocol for SiroSkin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients

Autor: Lea Dousset, Daniel C. Chambers, Angela Webster, Nicole Isbel, Scott Campbell, Carla Duarte, Louisa Collins, Diona Damian, Anne Tseng, Emma Karlsen, Olga Victoria Ilinsky, Susan Brown, Helmut Schaider, H. Peter Soyer, Daniel Ariza Ospino, Sam Hogarth, Alvin H. Chong, Victoria Mar, Scott McKenzie, Douglas Gin, Pablo Fernandez-Penas, Johannes S. Kern, Katja Loewe, Edwige Roy, Alan Herschtal, Kiarash Khosrotehrani

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-19 (2024)

Abstract Background Keratinocyte carcinomas such as basal cell carcinomas and squamous cell carcinomas are a major burden affecting morbidity and mortality in solid organ transplant recipients (SOTRs). Best treatment includes frequent skin checks for

Externí odkaz: https://doaj.org/article/a1ac03e4f2c14c4e803667c3886b11b0

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The effect of dichotomization of skewed adjustment covariates in the analysis of clinical trials

Autor: Alan Herschtal

Publikováno v: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-10 (2023)

Abstract Baseline imbalance in covariates associated with the primary outcome in clinical trials leads to bias in the reporting of results. Standard practice is to mitigate that bias by stratifying by those covariates in the randomization. Additional

Externí odkaz: https://doaj.org/article/c306dfc572234983ac5a6df3ffe14957

ASO Author Reflections: The Role of Postoperative Radiation Therapy Following Wide Excision of Neurotropic Melanoma of the Head and Neck: Now and into the Future.

Autor: Pinkham MB; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia. Mark.pinkham@health.qld.gov.au.; University of Queensland, Brisbane, Australia. Mark.pinkham@health.qld.gov.au., Herschtal A; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Hong AM; Department of Radiation Oncology, Chris O'Brien Lifehouse, Sydney, Australia.; Melanoma Institute Australia, The University of Sydney, Sydney, Australia.; Genesiscare, Mater Hospital, North Sydney, Australia., Chua MS; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VC, Australia., Scolyer RA; Melanoma Institute Australia, The University of Sydney, Sydney, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, Australia.; Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, Australia., Cumming S; Melanoma and Skin Cancer Research Centre, Monash University, Melbourne, Australia., Pullar A; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia.; University of Queensland, Brisbane, Australia.; Queensland University of Technology, Brisbane, Australia., Nobes J; Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK., Barker CA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Guadagnolo BA; Department of Radiation Oncology, MD Anderson Cancer Centre, Houston, TX, USA., Fogarty GB; ICON Cancer Centre, Revesby, Australia., Burmeister BH; University of Queensland, Brisbane, Australia.; GenesisCare Fraser Coast, Hervey Bay, Australia., Foote MC; Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia.; University of Queensland, Brisbane, Australia.

Publikováno v: Annals of surgical oncology [Ann Surg Oncol] 2024 Sep; Vol. 31 (9), pp. 6118-6119. Date of Electronic Publication: 2024 Jun 24.

The effect of dichotomization of skewed adjustment covariates in the analysis of clinical trials.

Autor: Herschtal, Alan¹ (AUTHOR) Alan.Herschtal@monash.edu

Publikováno v: BMC Medical Research Methodology. 3/13/2023, Vol. 23 Issue 1, p1-10. 10p.