Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Herschel S. Dhekne"'
Autor:
Herschel S Dhekne, Francesca Tonelli, Wondwossen M Yeshaw, Claire Y Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R Alessi, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 12 (2023)
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we showed previously that these phosphoRabs play an important role in LRRK2
Externí odkaz:
https://doaj.org/article/3565c7f6dcf745449d8d8cc68bd1cf97
Autor:
Edmundo G Vides, Ayan Adhikari, Claire Y Chiang, Pawel Lis, Elena Purlyte, Charles Limouse, Justin L Shumate, Elena Spínola-Lasso, Herschel S Dhekne, Dario R Alessi, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 11 (2022)
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017). Moreover, Golgi-associated Rab29 can recruit LRR
Externí odkaz:
https://doaj.org/article/3925beaf71f0417ebbc0fd002e21efb5
Autor:
Shahzad S Khan, Yuriko Sobu, Herschel S Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R Alessi, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 10 (2021)
Activating LRRK2 mutations cause Parkinson’s disease, and pathogenic LRRK2 kinase interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the dorsal striatum lose their cilia in R1441C LRRK2 mutant mice (Dhekne et al.,
Externí odkaz:
https://doaj.org/article/c486db2909d74097bd5b26027a1a91b2
Autor:
Herschel S. Dhekne, Francesca Tonelli, Wondwossen M. Yeshaw, Claire Y. Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R. Alessi, Suzanne R. Pfeffer
Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we showed previously that phosphoRabs play an important role in LRRK2 membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3257f216220943444e2beacd3afcc126
https://doi.org/10.1101/2023.02.17.529028
https://doi.org/10.1101/2023.02.17.529028
Autor:
Herschel S Dhekne, Izumi Yanatori, Rachel C Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R Alessi, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 7 (2018)
Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases, including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of
Externí odkaz:
https://doaj.org/article/40251dc7f4164289ae50d7ee75642695
Publikováno v:
Blood. 138:1490-1503
Extracellular vesicles (EVs) transfer functional molecules between cells. CD63 is a widely recognized EV marker that contributes to EV secretion from cells. However, the regulation of its expression remains largely unknown. Ferritin is a cellular iro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f437efab216a0095b4893f81051b408
https://doi.org/10.1182/blood.2021010995
https://doi.org/10.1182/blood.2021010995
Autor:
Martin Steger, Federico Diez, Herschel S Dhekne, Pawel Lis, Raja S Nirujogi, Ozge Karayel, Francesca Tonelli, Terina N Martinez, Esben Lorentzen, Suzanne R Pfeffer, Dario R Alessi, Matthias Mann
Publikováno v:
eLife, Vol 6 (2017)
We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein fami
Externí odkaz:
https://doaj.org/article/b78ecda69482408fa0764d4064ae35bc
Autor:
Edmundo G Vides, Ayan Adhikari, Claire Y Chiang, Pawel Lis, Elena Purlyte, Charles Limouse, Justin L Shumate, Elena Spínola-Lasso, Herschel S Dhekne, Dario R Alessi, Suzanne R Pfeffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5529d608bd60d4f0daa33683392c225
https://doi.org/10.7554/elife.79771.sa2
https://doi.org/10.7554/elife.79771.sa2
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mutations that activate LRRK2 protein kinase cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases, in particular Rab8 and Rab10. We show here details related to the mechanism by which Rab10 phosphorylation blocks initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79da4002b1a01cea62a1955c17a664bd
https://doi.org/10.1073/pnas.2005894118
https://doi.org/10.1073/pnas.2005894118