Výsledky vyhledávání - "Herschel M. Watkins"

Experimental Measurement of Surface Charge Effects on the Stability of a Surface-Bound Biopolymer

Autor: Francesco Ricci, Kevin W. Plaxco, Herschel M. Watkins

Publikováno v: Langmuir : the ACS journal of surfaces and colloids, vol 34, iss 49

Quantitative experimental studies of the thermodynamics with which biopolymers interact with specific surfaces remain quite limited. In response, here we describe experimental and theoretical studies of the change in folding free energy that occurs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13078087a163b86b0ef5fe7cee9f2ab6
https://doi.org/10.1021/acs.langmuir.8b01004

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Angular correlations of photons from solution diffraction at a free-electron laser encode molecular structure

Autor: Daniel Ratner, Derek Mendez, Herschel M. Watkins, Kevin S. Raines, Shenglan Qiao, Ganesh Subramanian, Gundolf Schenk, Garrett Nelson, Makina Yabashi, Sebastian Doniach, Thomas J. Lane, Kensuke Tono, Yasumasa Joti

Publikováno v: IUCrJ, Vol 3, Iss 6, Pp 420-429 (2016)
IUCrJ

An atomic twinning structure is observed by averaging intensity correlations from many snapshots of gold nanoparticles in solution.
During X-ray exposure of a molecular solution, photons scattered from the same molecule are correlated. If molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f61fe2664d825f56e982fb6bc33899e
https://doi.org/10.1107/s2052252516013956

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Entropic and Electrostatic Effects on the Folding Free Energy of a Surface-Attached Biomolecule: An Experimental and Theoretical Study

Autor: Alexis Vallée-Bélisle, Herschel M. Watkins, Francesco Ricci, Dmitrii E. Makarov, Kevin W. Plaxco

Publikováno v: Journal of the American Chemical Society. 134:2120-2126

Surface-tethered biomolecules play key roles in many biological processes and biotechnologies. However, while the physical consequences of such surface attachment have seen significant theoretical study, to date this issue has seen relatively little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b384febcbe7ac6bc17c9e758831d69d7
https://doi.org/10.1021/ja208436p

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Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model

Autor: Cheryll Williams-Skipp, Robert I. Scheinman, Herschel M. Watkins, Brent E. Palmer, Thiagarajan Raman, Robert J. Valuck

Publikováno v: Arthritis & Rheumatism. 60:408-418

Objective To examine the relative importance of tumor necrosis factor receptor I (TNFRI) signaling in the hematopoietic tissue compartment in the progression of collagen-induced arthritis (CIA), a model of rheumatoid arthritis (RA). Methods DBA/1 mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41b985e1cd32b0867f7d139216d1c324
https://doi.org/10.1002/art.24260

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Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions

Autor: Kevin W. Plaxco, Anna J. Simon, Herschel M. Watkins, Tobin R. Sosnick, Everett A. Lipman, Rex P. Hjelm

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 21

Small-angle scattering studies generally indicate that the dimensions of unfolded single-domain proteins are independent (to within experimental uncertainty of a few percent) of denaturant concentration. In contrast, single-molecule FRET (smFRET) stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5832c534806d15f2026834f8c403dc
https://escholarship.org/uc/item/3c69v08d

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Using the population-shift mechanism to rationally introduce 'Hill-type' cooperativity into a normally non-cooperative receptor

Autor: Francesco Ricci, Anna J. Simon, Herschel M. Watkins, Kevin W. Plaxco, Alexis Vallée-Bélisle

Publikováno v: Angewandte Chemie (International ed. in English), vol 53, iss 36

Allosteric cooperativity, which nature uses to improve the sensitivity with which biomolecular receptors respond to small changes in ligand concentration, could likewise be of use in improving the responsiveness of artificial biosystems. Thus motivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e836f76c76e8342b2af21ac18974593
https://escholarship.org/uc/item/04m1z6ss

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The Effects of Crowding on the Stability of a Surface-Tethered Biopolymer: An Experimental Study of Folding in a Highly Crowded Regime

Autor: Francesco Ricci, Anna J. Simon, Herschel M. Watkins, Kevin W. Plaxco

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, vol 136, iss 25

The high packing densities and fixed geometries with which biomolecules can be attached to macroscopic surfaces suggest that crowding effects may be particularly significant under these often densely packed conditions. Exploring this question experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b439667b7a772699b1b099069d4104
http://hdl.handle.net/2108/85787

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Using the Population-Shift Mechanism to Rationally Introduce 'Hilltype' Cooperativity into a Normally Non-Cooperative Receptor

Autor: Anna J. Simon, Alexis Valle-Blisle, Francesco Ricci, Herschel M. Watkins, and Kevin W. Plaxco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2659::8a9e2666fcd1d458401a80e85babae9d
https://zenodo.org/record/1169017

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Secondary Structure Elucidation via X-Ray Cross Correlation Analysis

Autor: Daniel Ratner, Thomas J. Lane, Derek Mendez, Jongmin Sung, Herschel M. Watkins, Sebastian Doniach

Publikováno v: Biophysical Journal. 106(2)

We aim to measure substantial structural information via X-ray scattering in the absence of an ordered system. Instead of a crystal, which consists of N particles at a single orientation relative to the X-ray beam, our samples consist of N randomly o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6610d2d3d864a5830ef29033d626681b

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Observation of correlated X-ray scattering at atomic resolution

Autor: Clément Levard, Jongmin Sung, Daniel Ratner, Sebastian Doniach, Vijay S. Pande, Thomas J. Lane, M. Soltis, James A. Spudich, Jonas A. Sellberg, Aina E. Cohen, Herschel M. Watkins, Shirley Sutton, Derek Mendez

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2014, 369 (1647), ⟨10.1098/rstb.2013.0315⟩
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014, 369 (1647), ⟨10.1098/rstb.2013.0315⟩

International audience; Tools to study disordered systems with local structural order, such as proteins in solution, remain limited. Such understanding is essential for e.g. rational drug design. Correlated X-ray scattering (CXS) has recently attract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063332f87b3aae0e4ae2643006eacc9d
https://hal.archives-ouvertes.fr/hal-01519372

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