Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Herschel Wade"'
Autor:
Shaohui Hu, Jun Wan, Yijing Su, Qifeng Song, Yaxue Zeng, Ha Nam Nguyen, Jaehoon Shin, Eric Cox, Hee Sool Rho, Crystal Woodard, Shuli Xia, Shuang Liu, Huibin Lyu, Guo-Li Ming, Herschel Wade, Hongjun Song, Jiang Qian, Heng Zhu
Publikováno v:
eLife, Vol 2 (2013)
DNA methylation, especially CpG methylation at promoter regions, has been generally considered as a potent epigenetic modification that prohibits transcription factor (TF) recruitment, resulting in transcription suppression. Here, we used a protein m
Externí odkaz:
https://doaj.org/article/8642ae0b23ca4623ab1a7419c8ee84c6
Publikováno v:
ChemMedChem. 12:426-430
BmrR is a multidrug resistance regulator that responds to diverse ligands. To obtain insights into signal recognition, allosteric control and cooperativity, we employed a quantitative in vitro transcription assay to determine the ligand-dependent act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebd247bf10f4f534b19aad38db058bc
https://doi.org/10.1002/cmdc.201700017
https://doi.org/10.1002/cmdc.201700017
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8522954c5df542b07267291cc17139af
https://doi.org/10.1096/fasebj.2019.33.1_supplement.673.14
https://doi.org/10.1096/fasebj.2019.33.1_supplement.673.14
Publikováno v:
ChemMedChem. 11:1038-1041
A medium-throughput approach (80+ compounds) to investigate allosteric transcriptional control in the multidrug resistance gene regulator BmrR, with cations, zwitterions, uncharged compounds and anions, is described. Even at the allosteric level, Bmr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cea109a7df2de8109319064e8b0d61a
https://doi.org/10.1002/cmdc.201600059
https://doi.org/10.1002/cmdc.201600059
Publikováno v:
Journal of Chemical Information and Modeling. 56:377-389
Solution-binding and molecular docking have been combined with a diverse collection of chemical probes to further elucidate multidrug (MD) recognition in BmrR. Whereas previous efforts have focused on structural elucidations of MD binding, the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6addcd752415939d1b02e9976bc541
https://doi.org/10.1021/acs.jcim.5b00704
https://doi.org/10.1021/acs.jcim.5b00704
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5505cc11520b71b714a7c72e9903805d
https://doi.org/10.1096/fasebj.2020.34.s1.05475
https://doi.org/10.1096/fasebj.2020.34.s1.05475
Autor:
Julie M. Lade, Bhargavi Narayanan, Kevin D. Dietz, Herschel Wade, Namandjé N. Bumpus, Carley J. S. Heck
Efavirenz (EFV), an antiretroviral that interacts clinically with co-administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450. We tested whether its primary metabolite, 8-hydroxyEFV (8-OHE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb96172dfd540c3289c6303ef19bf68b
https://europepmc.org/articles/PMC6081956/
https://europepmc.org/articles/PMC6081956/
Publikováno v:
Journal of Molecular Biology. 427:1695-1704
Intrinsic disorder provides a means of maximizing allosteric coupling in proteins. However, the mechanisms by which the disorder functions in allostery remain to be elucidated. Small ligand, bio-5'-AMP, binding and dimerization of the Escherichia col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8e2be63765e1ca41cf2054a283d9b6
https://doi.org/10.1016/j.jmb.2015.02.021
https://doi.org/10.1016/j.jmb.2015.02.021
Publikováno v:
Journal of Biological Chemistry. 286:36522-36531
Emerging resistance of human pathogens to anti-infective agents make it necessary to develop new agents to treat infection. The methylerythritol phosphate pathway has been identified as an anti-infective target, as this essential isoprenoid biosynthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d791376e97372f5f71de87802d73bfec
https://doi.org/10.1074/jbc.m111.259747
https://doi.org/10.1074/jbc.m111.259747
Publikováno v:
Proceedings of the National Academy of Sciences. 108:11046-11051
Current views of multidrug (MD) recognition focus on large drug-binding cavities with flexible elements. However, MD recognition in BmrR is supported by a small, rigid drug-binding pocket. Here, a detailed description of MD binding by the noncanonica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e260210ea508f0b14f5631cbf388cc
https://doi.org/10.1073/pnas.1104850108
https://doi.org/10.1073/pnas.1104850108