Probing cell identity hierarchies by fate titration and collision during direct reprogramming.

Autor: Hersbach, Bob A^1,2,3 (AUTHOR), Fischer, David S^4,5,6 (AUTHOR), Masserdotti, Giacomo^1,2 (AUTHOR), Deeksha^1,2 (AUTHOR), Mojžišová, Karolina⁴ (AUTHOR), Waltzhöni, Thomas^4,7 (AUTHOR), Rodriguez‐Terrones, Diego⁴ (AUTHOR), Heinig, Matthias^4,6 (AUTHOR), Theis, Fabian J^4,5,6,8 (AUTHOR) fabian.theis@helmholtz-muenchen.de, Götz, Magdalena^1,2,8 (AUTHOR) magdalena.goetz@helmholtz-muenchen.de, Stricker, Stefan H^1,2 (AUTHOR) stefan.stricker@helmholtz-muenchen.de

Publikováno v: Molecular Systems Biology. Sep2022, Vol. 18 Issue 9, p1-23. 23p.

Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease.

Autor: Pircs, Karolina, Drouin-Ouellet, Janelle, Horváth, Vivien, Gil, Jeovanis, Rezeli, Melinda, Garza, Raquel, Grassi, Daniela A, Sharma, Yogita, St-Amour, Isabelle, Harris, Kate, Jönsson, Marie E, Johansson, Pia A, Vuono, Romina, Fazal, Shaline V, Stoker, Thomas, Hersbach, Bob A, Sharma, Kritika, Lagerwall, Jessica, Lagerström, Stina, Storm, Petter

Publikováno v: Brain: A Journal of Neurology; Sep2022, Vol. 145 Issue 9, p3035-3057, 23p

Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease.

Autor: Brattås, Per Ludvik, Hersbach, Bob A., Madsen, Sofia, Petri, Rebecca, Jakobsson, Johan, Pircs, Karolina

Publikováno v: Autophagy; Jun2021, Vol. 17 Issue 6, p1316-1329, 14p

Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease.

Autor: Pircs K; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Drouin-Ouellet J; Faculty of Pharmacy, Université de Montréal, Montreal, QC H3T 1J4, Canada.; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, BMC A11 and B10, Lund University, S-221 84 Lund, Sweden., Horváth V; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Gil J; Oncology and Pathology, Kamprad Lab, Department of Clinical Sciences, Lund University, S-221 85 Lund, Sweden., Rezeli M; Clinical Protein Science and Imaging, Department of Biomedical Engineering, Lund University, S-221 85 Lund, Sweden., Garza R; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Grassi DA; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Sharma Y; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., St-Amour I; Axe Neurosciences, Centre de recherche du CHU de Québec, Université Laval, CHUL, Québec, QC, G1E 6W2, Canada.; CERVO Brain Research Center, Université Laval, Québec, QC, G1E 1T2, Canada., Harris K; Wellcome-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK., Jönsson ME; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Johansson PA; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Vuono R; Wellcome-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK., Fazal SV; Wellcome-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK., Stoker T; Wellcome-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK., Hersbach BA; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Sharma K; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Lagerwall J; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Lagerström S; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden., Storm P; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, BMC A11 and B10, Lund University, S-221 84 Lund, Sweden., Hébert SS; Axe Neurosciences, Centre de recherche du CHU de Québec, Université Laval, CHUL, Québec, QC, G1E 6W2, Canada., Marko-Varga G; Oncology and Pathology, Kamprad Lab, Department of Clinical Sciences, Lund University, S-221 85 Lund, Sweden., Parmar M; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, BMC A11 and B10, Lund University, S-221 84 Lund, Sweden., Barker RA; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, BMC A11 and B10, Lund University, S-221 84 Lund, Sweden.; Wellcome-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK., Jakobsson J; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, S-221 84 Lund, Sweden.

Publikováno v: Brain : a journal of neurology [Brain] 2022 Sep 14; Vol. 145 (9), pp. 3035-3057.