3D interaction homology: The hydrophobic residues alanine, isoleucine, leucine, proline and valine play different structural roles in soluble and membrane proteins

Autor: AL Mughram, Mohammed H., Catalano, Claudio, Herrington, Noah B., Safo, Martin K., Kellogg, Glen E.

Publikováno v: Frontiers in Molecular Biosciences. 10

The aliphatic hydrophobic amino acid residues—alanine, isoleucine, leucine, proline and valine—are among the most common found in proteins. Their structural role in proteins is seemingly obvious: engage in hydrophobic interactions to stabilize se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92daeaf38a13ed2acf00868d1c1bedda
https://doi.org/10.3389/fmolb.2023.1116868

Additional file 1 of Novel eIF4A1 inhibitors with anti‐tumor activity in lymphoma

Autor: Kayastha, Forum, Herrington, Noah B., Kapadia, Bandish, Roychowdhury, Anirban, Nanaji, Nahid, Kellogg, Glen E., Gartenhaus, Ronald B.

Additional file 1: Figure S1. eIF4A1 expression in molecular subtypes of DLBCL in microarray datasets. A) eIF4A1 expression was found to be significantly (***p < 0.001) higher in ABC-DLBCL subtypes compared to GCB and UN-DLBCL in the microarray datas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47dd464d3284a0b61f0bb12e5a1df8f

Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling.

Autor: Perry, Charles K.¹ (AUTHOR) charles.perry@vanderbilt.edu, Casey, Austen B.¹ (AUTHOR), Felsing, Daniel E.¹ (AUTHOR), Vemula, Rajender¹ (AUTHOR), Zaka, Mehreen¹ (AUTHOR), Herrington, Noah B.² (AUTHOR), Cui, Meng¹ (AUTHOR), Kellogg, Glen E.² (AUTHOR), Canal, Clinton E.¹ (AUTHOR), Booth, Raymond G.¹ (AUTHOR)

Publikováno v: Bioorganic & Medicinal Chemistry. Feb2020, Vol. 28 Issue 3, pN.PAG-N.PAG. 1p.

Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins.

Autor: Al Mughram MH; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery, and Development, Virginia Commonwealth University, Richmond, Virginia, USA., Herrington NB; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery, and Development, Virginia Commonwealth University, Richmond, Virginia, USA., Catalano C; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery, and Development, Virginia Commonwealth University, Richmond, Virginia, USA., Kellogg GE; Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery, and Development, Virginia Commonwealth University, Richmond, Virginia, USA.; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, USA.

Publikováno v: Journal of structural biology: X [J Struct Biol X] 2021 Nov 30; Vol. 5, pp. 100055. Date of Electronic Publication: 2021 Nov 30 (Print Publication: 2021).