LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Autor: Cobo-Vuilleumier N; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Lorenzo PI; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Rodríguez NG; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Herrera Gómez IG; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Fuente-Martin E; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., López-Noriega L; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Mellado-Gil JM; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Romero-Zerbo SY; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, 29010, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., Baquié M; Neurix SA, Geneva, 1228, Switzerland., Lachaud CC; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Stifter K; Ulm University Hospital, Ulm, 89081, Germany., Perdomo G; Facultad de Ciencias de la Salud, Universidad de Burgos, Burgos, 09001, Spain., Bugliani M; Department Clinical and Experimental Medicine, University of Pisa-AOUP University Hospital, Pisa, 56126, Italy., De Tata V; Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, 56126, Italy., Bosco D; Cell Isolation and Transplantation Centre, University Hospital, Geneva, 1211, Switzerland., Parnaud G; Cell Isolation and Transplantation Centre, University Hospital, Geneva, 1211, Switzerland., Pozo D; Department of Cell Dynamics and Signalling, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain., Hmadcha A; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., Florido JP; Clinical Bioinformatics Area, Fundación Progreso y Salud, Consejería de Salud, Seville, 41013, Spain., Toscano MG; Amarna Therapeutics, Seville, 41092, Spain., de Haan P; Amarna Therapeutics, Seville, 41092, Spain., Schoonjans K; Laboratory of Metabolic Signaling, EPFL, Lausanne, 1015, Switzerland., Sánchez Palazón L; Biological Resources, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain., Marchetti P; Department Clinical and Experimental Medicine, University of Pisa-AOUP University Hospital, Pisa, 56126, Italy., Schirmbeck R; Ulm University Hospital, Ulm, 89081, Germany., Martín-Montalvo A; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain., Meda P; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, 1211, Switzerland., Soria B; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., Bermúdez-Silva FJ; Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, 29010, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain., St-Onge L; Neuried, Munich, 82061, Germany., Gauthier BR; Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain. benoit.gauthier@cabimer.es.

Publikováno v: Nature communications [Nat Commun] 2018 Apr 16; Vol. 9 (1), pp. 1488. Date of Electronic Publication: 2018 Apr 16.