Zobrazeno 1 - 10 of 173 pro vyhledávání: '"Herren, Wu"'
1
Akademický článek
In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance
Autor: Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting. Additionally, th
Externí odkaz: https://doaj.org/article/2b758208695d4e46949303210404e03c
Zobrazit plný text záznamu
2
Akademický článek
Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs
Autor: Amit Kumar, Krista Kinneer, Luke Masterson, Ebele Ezeadi, Philip Howard, Herren Wu, Changshou Gao, Nazzareno Dimasi
Publikováno v: Data in Brief, Vol 21, Iss , Pp 2208-2220 (2018)
Experimental procedures and 1H and 13C NMR of the heterotrifunctional linker used for preparation of dual drug conjugates and PBD payload are included. Procedure for carrying preparation of antibody linker conjugate via thiol maleimide conjugation an
Externí odkaz: https://doaj.org/article/41459ffd231a4a34a2e4d5778c753c5e
Zobrazit plný text záznamu
4
Akademický článek
Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen
Autor: Bo Wang, Chunning Yang, Xiaofang Jin, Qun Du, Herren Wu, William Dall’Acqua, Yariv Mazor
Publikováno v: mAbs, Vol 12, Iss 1 (2020)
Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between t
Externí odkaz: https://doaj.org/article/5ce3a9d83ee34780b0707e2364352601
Zobrazit plný text záznamu
5
Akademický článek
Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models.
Autor: Kevin L Allen, Jennifer Cann, Weiguang Zhao, Norman Peterson, Michelle Lazzaro, Haihong Zhong, Herren Wu, William F Dall'Acqua, M Jack Borrok, Melissa M Damschroder, Ping Tsui, Qing Li
Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0234268 (2020)
Annexin A1 (anxA1) is an immunomodulatory protein that has been proposed as a tumor vascular target for antitumor biologic agents, yet to date the vascular expression of anxA1 in specific tumor indications has not been systematically assessed. Attemp
Externí odkaz: https://doaj.org/article/0083d0c4b3bf4781a3221ea58fe585e7
Zobrazit plný text záznamu
6
Akademický článek
Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity
Autor: Shaoyi Chen, Stelios Florinas, Abigail Teitgen, Ze-Qi Xu, Changshou Gao, Herren Wu, Kazunori Kataoka, Horacio Cabral, R. James Christie
Publikováno v: Science and Technology of Advanced Materials, Vol 18, Iss 1, Pp 666-680 (2017)
Antibodies and antigen-binding fragments (Fabs) can be used to modify the surface of nanoparticles for enhanced target binding. In our previous work, site-specific conjugation of Fabs to polymeric micelles using conventional methods was limited to ap
Externí odkaz: https://doaj.org/article/b423f9a767e449a38ca1171b022ccd48
Zobrazit plný text záznamu
8
Akademický článek
Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.
Autor: Reena Varkey, Qun Du, Jodi L Karnell, Xiaodong Xiao, Kerry A Casey, Rob Woods, Kim Rosenthal, Susan Wilson, William F Dall'Acqua, Herren Wu, Ronald Herbst, Rachel Ettinger, Melissa Damschroder
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0211236 (2019)
Interleukin-21 (IL-21), a member of the common cytokine receptor γ chain (γc) family, is secreted by CD4+ T cells and natural killer T cells and induces effector function through interactions with the IL-21 receptor (IL-21R)/γc complex expressed o
Externí odkaz: https://doaj.org/article/e7e6a5a71ae44ef09369d6a607a0b924
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje