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Akademický článek

Carvedilol inhibits neuronal hyperexcitability caused by epilepsy-associated KCNT1 mutations.

Autor: Di C; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.; Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China., Wu T; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Gao K; Department of Pediatrics, Peking University First Hospital, Beijing, China.; Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases, Beijing, China.; Children Epilepsy Center, Peking University First Hospital, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, China., Li N; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Song H; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Wang L; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Sun H; UCL School of Pharmacy, University College London, London, UK., Yi J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Zhang X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Chen J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Shah M; UCL School of Pharmacy, University College London, London, UK., Jiang Y; Department of Pediatrics, Peking University First Hospital, Beijing, China.; Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases, Beijing, China.; Children Epilepsy Center, Peking University First Hospital, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, China., Huang Z; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.; IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2025 Jan; Vol. 182 (1), pp. 162-180. Date of Electronic Publication: 2024 Oct 06.

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Akademický článek

Autor: Brunetti S; Unit of Child Neurology and Psychiatry, ASST Spedali Civili of Brescia, Brescia, Italy., Muda A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Conti C; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Gazzina S; Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili of Brescia, Brescia, Italy., Accorsi P; Unit of Child Neurology and Psychiatry, ASST Spedali Civili of Brescia, Brescia, Italy., Giordano L; Unit of Child Neurology and Psychiatry, ASST Spedali Civili of Brescia, Brescia, Italy.

Publikováno v: American journal of medical genetics. Part A [Am J Med Genet A] 2024 Nov; Vol. 194 (11), pp. e63813. Date of Electronic Publication: 2024 Jul 08.

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Akademický článek

Oxidative stress‐related cellular aging causes dysfunction of the Kv3.1/KCNC1 channel reverted by melatonin.

Autor: Spinelli, Sara¹ (AUTHOR), Remigante, Alessia¹ (AUTHOR), Liuni, Raffaella² (AUTHOR), Mantegna, Gianluca¹ (AUTHOR), Legname, Giuseppe³ (AUTHOR), Marino, Angela¹ (AUTHOR), Morabito, Rossana¹ (AUTHOR), Dossena, Silvia^2,4 (AUTHOR) silvia.dossena@pmu.ac.at

Publikováno v: Aging Cell. Aug2024, Vol. 23 Issue 8, p1-16. 16p.

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Akademický článek

The research team of Prof. Zhuo Huang found that Carvedilol inhibits neonatal malignant epilepsy caused by KCNT1 mutation, providing new hope for the treatment of refractory epilepsy.

Publikováno v: Journal of Chinese Pharmaceutical Sciences. Nov2024, Vol. 33 Issue 11, p1092-1094. 3p.

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Akademický článek

A Case Report of Parental Germline Mosaicism in the PCDH19 Gene of Two Iranian Siblings.

Autor: Alijanpour, Sahar¹, Ghafouri-Fard, Soudeh¹, Tonekaboni, Seyed Hassan², Karimzadeh, Parvaneh², Ahmadabadi, Farzad², Rahimian, Elham³, Panjeshahi, Samareh¹, Miryounesi, Mohammad¹ miryounesi@sbmu.ac.ir

Publikováno v: Basic & Clinical Neuroscience. Jul/Aug2024, Vol. 15 Issue 4, p541-552. 12p.

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Akademický článek

Structural basis for human Ca v 3.2 inhibition by selective antagonists.

Autor: Huang J; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Fan X; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. fanxiao0606@gmail.com.; Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY, USA. fanxiao0606@gmail.com., Jin X; Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Lyu C; Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Guo Q; Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Liu T; Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Chen J; Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China., Davakan A; IGF, Université de Montpellier, CNRS, INSERM, LabEx 'Ion Channel Science and Therapeutics', Montpellier, France., Lory P; IGF, Université de Montpellier, CNRS, INSERM, LabEx 'Ion Channel Science and Therapeutics', Montpellier, France., Yan N; Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. nyan@tsinghua.edu.cn.; Institute of Bio-Architecture and Bio-Interactions, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong, China. nyan@tsinghua.edu.cn.

Publikováno v: Cell research [Cell Res] 2024 Jun; Vol. 34 (6), pp. 440-450. Date of Electronic Publication: 2024 Apr 11.

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