Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hernani L. S. Maia"'
Publikováno v:
The Journal of Physical Chemistry B. 107:14556-14562
C(α)-C(α)dialkylglycines, sarcosine, O-methyltyrosine and β-(imidazol-1-yl)-alanine are noncoded amino acids with a large pharmaceutical potential. We have developed a set of parameters for these amino acids, consistent with the AMBER force field.
Publikováno v:
Organic & Biomolecular Chemistry. 1:1475-1479
A general and simple strategy for routine peptide synthesis with α,α-dialkyl glycines taking advantage of the four-component Ugi–Passerini reaction is presented. The isonitrile required for the reaction can be relatively simple and its selection
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :97-101
Synthetic and spectroscopic details relating to a set of heteroaromatic N-benzyl carboxamides and in particular the corresponding tert-butyl acylcarbamates are reported. These compounds were required to study the postulated effect of various heterocy
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :3167-3173
Michael additions of nitrogen heterocycles, thiols, carbon nucleophiles and amines to dehydroalanine derivatives, including a glycyldehydroalanine peptide, are performed in fair to good yields. Didehydroaminobutyric acid derivatives react only with t
Publikováno v:
Tetrahedron Letters. 41:7437-7441
β-Substituted α,β-dehydroamino acids are synthesised in high yields by a Michael addition of heterocyclic nucleophiles to the methyl esters of N-tert -butyloxycarbonyl, N -(4-toluenesulfonyl)dehydroamino acids, followed by a base-induced eliminati
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
By using a 4-dimethylaminopyridine (DMAP) catalysed reaction of β-hydroxyamino acid derivatives with tert- butyl pyrocarbonate [(Boc)2O], dehydroamino acid derivatives are obtained in high yields. The same methodology applied to dipeptides with a β
Autor:
G. M. E. Soares, João C.V.P. Moura, R. Hrdina, Jaime Rocha Gomes, Hernani L. S. Maia, Ana M. F. Oliveira-Campos
Publikováno v:
Journal of the Society of Dyers and Colourists. 112:19-22
The synthesis of a reactive dye in the anhydride form is described, and its kinetics of hydrolysis investigated at various pH values. Two different hydrolysis products were identified. The experimental rate constants were determined by nonlinear appr
Autor:
A. Wahhab, Thomas Mavromoustakos, John Hondrelis, Graham J. Moore, Dimitris Panagiotopoulos, Qiao Wu, Raghav Yamdagni, Renee C. Ganter, Hernani L. S. Maia, George Agelis, John Matsoukas
Publikováno v:
Journal of Medicinal Chemistry. 38:4660-4669
Type I angiotensin II antagonists with O-methyl-L-homoserine [HSer(gamma-OMe)] and delta-methoxy-L-norvaline [Nva(delta-OMe)] at position 8 have been prepared by the solid-phase method, purified by reverse-phase HPLC, and bioassayed in the rat uterus
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Di-tert-butyl acylimidodicarbonates, prepared from primary amides with two equivalents of di-tert-butyl dicarbonate under catalysis by 4-dimethylaminopyridine, readily undergo selective reductive cleavage of their acyl CO-N bonds by NaBH4 to provide
Publikováno v:
ChemInform. 30
By using a DMAP catalysed reaction of β-hydroxyamino acid derivatives with tert-butylpyrocarbonate, the corresponding dehydroamino acid derivatives were obtained in high yields.