Targeting UDP-α-d-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth

Autor: Daqian Zhan, Fatih Yalcin, Ding Ma, Yi Fu, Shuang Wei, Bachchu Lal, Yunqing Li, Omar Dzaye, John Laterra, Mingyao Ying, Hernando Lopez-Bertoni, Shuli Xia

Publikováno v: Genes and Diseases, Vol 9, Iss 3, Pp 717-730 (2022)

Glioblastoma (GBM, WHO grade IV glioma) is the most common and lethal malignant brain tumor in adults with a dismal prognosis. The extracellular matrix (ECM) supports GBM progression by promoting tumor cell proliferation, migration, and immune escape

Externí odkaz: https://doaj.org/article/a5a043bb29f6446ea101dbfafff3a3ee

Exploring glioblastoma stem cell heterogeneity: Immune microenvironment modulation and therapeutic opportunities

Autor: Amanda L. Johnson, John Laterra, Hernando Lopez-Bertoni

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Despite its growing use in cancer treatment, immunotherapy has been virtually ineffective in clinical trials for gliomas. The inherently cold tumor immune microenvironment (TIME) in gliomas, characterized by a high ratio of pro-tumor to anti-tumor im

Externí odkaz: https://doaj.org/article/5cf6b9a7d58a4246a2ecba8d6af7169f

TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents

Autor: Jonathan B. Coulter, Hernando Lopez-Bertoni, Katherine J. Kuhns, Richard S. Lee, John Laterra, Joseph P. Bressler

Publikováno v: Epigenetics, Vol 12, Iss 10, Pp 854-864 (2017)

Recent studies have shown that loss of TET1 may play a significant role in the formation of tumors. Because genomic instability is a hallmark of cancer, we examined the potential involvement of 10-11 translocation 1 (TET1) in the DNA damage response

Externí odkaz: https://doaj.org/article/10b62dc99e4b4a36a4a9e11839850d2e

Development of a Risk Prediction Score for Occult Cancer in Patients With VTE

Autor: Monreal, Manuel, Decousus, Hervè, Prandoni, Paolo, Brenner, Benjamin, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Wells, Philip, Papadakis, Manolis, Aibar, M.A., Alfonso, M., Asensio-Cruz, M.I., Auguet, T., Arcelus, J.I., Barba, R., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Blanco-Molina, A., Bueso, T., Cañas, I., Ceausu, A., Chic, N., Culla, A., del Pozo, R., del Toro, J., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Duffort, M., Elias-Hernández, T., Falgá, C., Fernández-Aracil, C., Fernández-Capitán, C., Fidalgo, M.A., Font, C., Font, L., Gallego, P., García, M.A., García-Bragado, F., García-Rodenas, M., Gómez, V., González, J., Grau, E., Grimón, A., Guijarro, R., Guirado, L., Gutiérrez, J., Hernández-Comes, G., Hernández-Blasco, L., Hernando-López, E., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Joya, M.D., Llamas, P., Lecumberri, R., Lobo, J.L., López-Jiménez, L., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Maestre, A., Marchena, P.J., Martín, M., Martín-Martos, F., Monreal, M., Nieto, J.A., Nieto, S., Núñez, A., Núñez, M.J., Odriozola, M., Otalora, S., Otero, R., Ovejero, A., Pedrajas, J.M., Pérez, G., Pérez-Ductor, C., Peris, M.L., Porras, J.A., Reig, O., Riera-Mestre, A., Riesco, D., Rivas, A., Rodríguez-Dávila, M.A., Rosa, V., Ruiz-Artacho, P., Ruiz-Giménez, N., Sahuquillo, J.C., Sala-Sainz, M.C., Sampériz, A., Sánchez, R., Sanz, O., Soler, S., Sopeña, B., Suriñach, J.M., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Vela, J., Vicente, P., Vidal, G., Villalobos, A., Villalta, J., Vanassche, T., Verhamme, P., Wells, P., Hirmerova, J., Malý, R., Salgado, E., Bertoletti, L., Bura-Riviere, A., Farge-Bancel, D., Hij, A., Mahé, I., Merah, A., Moustafa, F., Papadakis, M., Braester, A., Brenner, B., Tzoran, I., Antonucci, G., Barillari, G., Bertone, A., Bilora, F., Bortoluzzi, C., Ciammaichella, M., Di Girolamo, C., Di Micco, P., Duce, R., Ferrazzi, P., Giorgi-Pierfranceschi, M., Grandone, E., Lodigiani, C., Maida, R., Mastroiacovo, D., Pace, F., Pesavento, R., Pinelli, M., Poggio, R., Prandoni, P., Rota, L., Tiraferri, E., Tonello, D., Tufano, A., Visonà, A., Zalunardo, B., Drucka, E., Kigitovica, D., Skride, A., Sousa, M.S., Bosevski, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Jara-Palomares, Luis, Otero, Remedios, Jimenez, David, Carrier, Marc, Margeli, Mireia, Praena-Fernandez, Juan Manuel, Grandone, Elvira

Publikováno v: In Chest March 2017 151(3):564-571

Supplementary Material, Table 1, Supplementary Figures 1-8 from Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence

Autor: Shuli Xia, Hernando Lopez-Bertoni, Alan Meeker, Yunqing Li, Mingyao Ying, John Laterra, Charles Eberhart, Yi Fu, Bachchu Lal, Shuang Wei, Ding Ma, Daqian Zhan

Supplementary Table 1. Primers used for qRT-PCR Supplementary Fig. 1. Heterozygous IDH1R132H/WT enhanced therapy-induced senescence in glioma cells. Supplementary Fig. 2. a. Schematic graph of genome editing strategy with two guide RNAs to knock out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c7a77d9f6ac5d15ed2eff1238245ee
https://doi.org/10.1158/1541-7786.22526966