Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states.

Autor: Müller TR; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Sekine T; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Trubach D; Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark., Niessl J; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Chen P; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Bergman P; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Laboratory Medicine, Clinical Immunology, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden., Blennow O; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Transplantation, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden., Hansson L; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden., Mielke S; Department of Laboratory Medicine, Biomolecular and Cellular Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Stockholm, Sweden., Nowak P; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.; Laboratory for Molecular Infection Medicine Sweden MIMS, Umeå University, Umeå, Sweden., Vesterbacka J; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden., Akber M; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Olofsson A; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Amaya Hernandez SP; Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark., Gao Y; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Cai C; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Söderdahl G; Department of Transplantation, Karolinska University Hospital, Stockholm, Sweden.; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Smith CIE; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Laboratory Medicine, Biomolecular and Cellular Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Stockholm, Sweden., Österborg A; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden., Loré K; Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Sällberg Chen M; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden., Ljungman P; Department of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST), Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Medicine Huddinge, Hematology, Karolinska Institutet, Stockholm, Sweden., Ljunggren HG; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Karlsson AC; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.; Karolinska University Laboratory, Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden., Saini SK; Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kongens Lyngby, Denmark., Aleman S; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine Huddinge, Infectious Diseases, Karolinska Institutet, Stockholm, Sweden., Buggert M; Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jul 12; Vol. 15 (704), pp. eadg9452. Date of Electronic Publication: 2023 Jul 12.

Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias.

Autor: Sun DL; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA.; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Poddar S; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA., Pan RD; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA.; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Rosser EW; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA.; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Abt ER; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA., Van Valkenburgh J; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA.; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Le TM; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA., Lok V; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu., Hernandez SP; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Song J; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu., Li J; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu., Turlik A; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Chen X; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Cheng CA; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu.; Department of Bioengineering , University of California, Los Angeles , CA 90095 , USA., Chen W; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Mona CE; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA., Stuparu AD; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA., Vergnes L; Department of Human Genetics , David Geffen School of Medicine , University of California, Los Angeles , California 90095 , USA., Reue K; Department of Human Genetics , David Geffen School of Medicine , University of California, Los Angeles , California 90095 , USA.; Molecular Biology Institute , University of California, Los Angeles , California 90095 , USA., Damoiseaux R; UCLA Metabolomic Center , University of California, Los Angeles , Los Angeles , California 90095 , USA., Zink JI; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Czernin J; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA., Donahue TR; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA.; Department of Surgery , University of California, Los Angeles , CA 90095 , USA., Houk KN; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Jung ME; Department of Chemistry and Biochemistry , University of California, Los Angeles , California 90095 , USA . Email: jung@chem.ucla.edu., Radu CG; Department of Molecular and Medical Pharmacology , University of California, Los Angeles , California 90095 , USA . Email: cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division , University of California, Los Angeles , California 90095 , USA.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2020 Feb 24; Vol. 11 (3), pp. 392-410. Date of Electronic Publication: 2020 Feb 24 (Print Publication: 2020).

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S13.1 (Oral Abstract Presentation): The vaginal immunoproteome differs between women who ultimately deliver at term and those who undergo spontaneous preterm birth.

Publikováno v: American Journal of Reproductive Immunology. May2022 Supplement S1, Vol. 87, p59-60. 2p.