Systems toxicology studies reveal important insights about chronic exposure of zebrafish to Kalanchoe pinnata (Lam.) Pers leaf - KPL: Implications for medicinal use.

Autor: Martins Fernandes Pereira K; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04021-001, São Paulo, SP, Brazil. Electronic address: kassiamfp@hotmail.com., de Carvalho AC; Department of Chemistry, Universidade Federal de São Paulo, 09972-270, Diadema, SP, Brazil. Electronic address: ac.carvalho08@unifesp.br., Ventura Fernandes BH; Technical Directorate of Support for Teaching, Research and Innovation at the Faculty of Medicine of the University of São Paulo, São Paulo, SP, Brazil. Electronic address: bianca.ventura@fm.usp.br., Dos Santos Grecco S; Department of Chemistry, Universidade Federal de São Paulo, 09972-270, Diadema, SP, Brazil; Triplet Biotechnology Solutions, São Paulo, Brazil. Electronic address: simonegrecco@tripletbs.com., Rodrigues E; Center for Ethnobotanical and Ethnopharmacological Studies, Department of Environmental Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: e.rodrigues@unifesp.br., da Silva Fernandes MJ; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04021-001, São Paulo, SP, Brazil. Electronic address: fernandesepm@gmail.com., de Carvalho LRS; Technical Directorate of Support for Teaching, Research and Innovation at the Faculty of Medicine of the University of São Paulo, São Paulo, SP, Brazil; Discipline of Endocrinology, Laboratory of Hormones and Molecular Genetics-LIM42, Hospital das Clínicas of the University of São Paulo, São Paulo, SP, Brazil. Electronic address: luciani.carvalho@hc.fm.usp.br., Nakamura MU; Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, SP, 04021-001, Brazil. Electronic address: mary.uchiyama0@gmail.com., Guo S; Department of Bioengineering and Therapeutic Sciences, Programs in Biological Sciences and Human Genetics, University of California, San Francisco, CA, 94158-2811, USA. Electronic address: su.guo@ucsf.edu., Hernández RB; Laboratory of Bioinorganic and Environmental Toxicology - LABITA, Department of Exact and Earth Sciences, Universidade Federal de São Paulo, 09972-270, Diadema, SP, Brazil. Electronic address: rbhernandez@unifesp.br.

Publikováno v: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Nov 10; Vol. 338 (Pt 2), pp. 119044. Date of Electronic Publication: 2024 Nov 10.

Manganese-induced neurotoxicity in cerebellar granule neurons due to perturbation of cell network pathways with potential implications for neurodegenerative disorders.

Autor: Hernández RB; Laboratory of Bioinorganic and Environmental Toxicology - LABITA, Department of Exact and Earth Sciences, Federal University of São Paulo, Rua Prof. Artur Riedel, 275, CEP 09972-270, Diadema, SP, Brazil. rbhernandez@unifesp.br., Carrascal M, Abian J, Michalke B, Farina M, Gonzalez YR, Iyirhiaro GO, Moteshareie H, Burnside D, Golshani A, Suñol C

Publikováno v: Metallomics : integrated biometal science [Metallomics] 2020 Nov 01; Vol. 12 (11), pp. 1656-1678. Date of Electronic Publication: 2020 Sep 07.

Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast.

Autor: Moteshareie H; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada.; Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada., Hajikarimlou M; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Mulet Indrayanti A; Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada., Burnside D; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Paula Dias A; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Lettl C; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Ahmed D; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada.; Department of Health Sciences, Carleton University, Ottawa, Ontario, Canada., Omidi K; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Kazmirchuk T; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Puchacz N; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Zare N; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Takallou S; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Naing T; Department of Health Sciences, Carleton University, Ottawa, Ontario, Canada., Hernández RB; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada.; University Federal de São Paulo Departamento de Química, Laboratorio de Bioinorgânica e Toxicologia Ambiental - LABITA, São Paulo, Brazil., Willmore WG; Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada., Babu M; Department of Biochemistry, Research and Innovation Centre, University of Regina, Regina, Canada., McKay B; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada., Samanfar B; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada.; Agriculture and Agri-Food Canada, Ottawa Research and Development Centre (ORDC), Ottawa, Ontario, Canada., Holcik M; Department of Health Sciences, Carleton University, Ottawa, Ontario, Canada., Golshani A; Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, Ontario, Canada.; Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada.

Publikováno v: PloS one [PLoS One] 2018 Sep 19; Vol. 13 (9), pp. e0198704. Date of Electronic Publication: 2018 Sep 19 (Print Publication: 2018).

The role of chemical speciation, chemical fractionation and calcium disruption in manganese-induced developmental toxicity in zebrafish (Danio rerio) embryos.

Autor: Hernández RB; Federal University of São Paulo - Unifesp Campus Diadema, Deparment of Exact and Earth Sciences, Laboratory of Bioinorganic and Environmental Toxicology - LABITA, Rua Prof. Artur Riedel, 275, CEP: 09972-270, Diadema, SP, Brazil. Electronic address: rbhernandez@unifesp.br., Nishita MI; Federal University of São Paulo - Unifesp Campus Diadema, Deparment of Exact and Earth Sciences, Laboratory of Bioinorganic and Environmental Toxicology - LABITA, Rua Prof. Artur Riedel, 275, CEP: 09972-270, Diadema, SP, Brazil., Espósito BP; University of São Paulo, Institute of Chemistry, Av. Lineu Prestes 748, CEP: 05508-000, São Paulo, SP, Brazil., Scholz S; Helmholtz Centre for Environmental Research - UFZ, Department of Bioanalytical Ecotoxicology, Permoserstr. 15, 04318 Leipzig, Germany., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich - German Research Center for Environmental Health GmbH, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

Publikováno v: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2015 Oct; Vol. 32, pp. 209-17. Date of Electronic Publication: 2015 Jul 10.

Mechanisms of manganese-induced neurotoxicity in primary neuronal cultures: the role of manganese speciation and cell type.

Autor: Hernández RB; Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biomèdiques de Barcelona, IIBB-CSIC-IDIBAPS, Barcelona 08036, Spain., Farina M, Espósito BP, Souza-Pinto NC, Barbosa F Jr, Suñol C

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2011 Dec; Vol. 124 (2), pp. 414-23. Date of Electronic Publication: 2011 Sep 22.