Glial cells in the center of future ischemic stroke treatments.

Autor: Hernández IH; Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Pérez-Álvarez MJ; Departamento de Biología (Fisiología Animal) Facultad de Ciencias, Universidad Autónoma de Madrid, and Instituto de Biología Molecular-CBMSO, UAM/CSIC, Madrid, Spain.

Publikováno v: Neural regeneration research [Neural Regen Res] 2022 Dec; Vol. 17 (12), pp. 2659-2660.

CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.

Autor: Picó S; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain., Parras A; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain., Santos-Galindo M; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain., Pose-Utrilla J; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid 28029, Spain., Castro M; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), Madrid 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain., Fraga E; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain., Hernández IH; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Facultad de Ciencias, Departamento de Biología (Unidad Docente Fisiología Animal), Universidad Autónoma de Madrid, Madrid 28049, Spain., Elorza A; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain., Anta H; Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Unidad Asociada I+D+i IMIM-IIBB (CSIC), Barcelona 08003, Spain.; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain., Wang N; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Martí-Sánchez L; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain.; Department of Clinical Biochemistry, Institut de Recerca Sant Joan de Déu, Barcelona 08950, Spain., Belloc E; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain., Garcia-Esparcia P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Institute of Neuropathology, IDIBELL-University Hospital Bellvitge, University of Barcelona, Hospitalet de Llobregat, Barcelona 08908, Spain., Garrido JJ; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal (CSIC), Madrid 28002, Spain., Ferrer I; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Institute of Neuropathology, IDIBELL-University Hospital Bellvitge, University of Barcelona, Hospitalet de Llobregat, Barcelona 08908, Spain., Macías-García D; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla 41013, Spain., Mir P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla 41013, Spain., Artuch R; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain.; Department of Clinical Biochemistry, Institut de Recerca Sant Joan de Déu, Barcelona 08950, Spain., Pérez B; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Centro de Diagnóstico de Enfermedades Moleculares (CEDEM), Madrid 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid,28029, Spain., Hernández F; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain., Navarro P; Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Unidad Asociada I+D+i IMIM-IIBB (CSIC), Barcelona 08003, Spain.; Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain., López-Sendón JL; Department of Neurology, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28034, Spain., Iglesias T; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid 28029, Spain., Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Méndez R; Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain., Lucas JJ; Center for Molecular Biology 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, 28049, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, 28031, Spain.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Sep 29; Vol. 13 (613), pp. eabe7104. Date of Electronic Publication: 2021 Sep 29.

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease.

Autor: García-Escudero V; Departamento de Anatomía, Histología y Neurociencia, School of Medicine, Autonoma de Madrid University (UAM), Arzobispo Morcillo, 4, 28029, Madrid, Spain.; Graduate Program in Neuroscience, Autonoma de Madrid University (UAM), Arzobispo Morcillo, 4, 28029, Madrid, Spain.; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain., Ruiz-Gabarre D; Departamento de Anatomía, Histología y Neurociencia, School of Medicine, Autonoma de Madrid University (UAM), Arzobispo Morcillo, 4, 28029, Madrid, Spain.; Graduate Program in Neuroscience, Autonoma de Madrid University (UAM), Arzobispo Morcillo, 4, 28029, Madrid, Spain.; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain., Gargini R; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain.; Neurooncology Unit, Instituto de Salud Carlos III-UFIEC, 28220, Madrid, Spain., Pérez M; Departamento de Anatomía, Histología y Neurociencia, School of Medicine, Autonoma de Madrid University (UAM), Arzobispo Morcillo, 4, 28029, Madrid, Spain.; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain., García E; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain., Cuadros R; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain., Hernández IH; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain., Cabrera JR; Unidad de Investigación, Fundación Hospital de Jove, 33290, Gijón, Spain., García-Escudero R; Molecular Oncology Unit, CIEMAT, Ave Complutense, 40, 28040, Madrid, Spain.; Hospital 12 Octubre Research Institute/CIEMAT, Madrid, Spain.; Centro de Investigación Biomédica en Red de Cancer (CIBERONC), Valderrebollo, 5, 28031, Madrid, Spain., Lucas JJ; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28031, Madrid, Spain., Hernández F; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28031, Madrid, Spain., Ávila J; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM). Nicolás Cabrera, 1. Cantoblanco, 28049, Madrid, Spain. javila@cbm.csic.es.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28031, Madrid, Spain. javila@cbm.csic.es.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2021 Jul; Vol. 142 (1), pp. 159-177. Date of Electronic Publication: 2021 May 02.

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.

Autor: Migazzi A; Laboratory of Transcriptional Neurobiology, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy; Dulbecco Telethon Institute, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy; Department of Biomedical Sciences (DBS), University of Padova, Padova 35131, Italy., Scaramuzzino C; Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, GIN, Grenoble 38000, France., Anderson EN; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Tripathy D; Laboratory of Transcriptional Neurobiology, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy., Hernández IH; Centro de Biología Molecular 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid 28029, Spain., Grant RA; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Roccuzzo M; Advanced Imaging Core Facility, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy., Tosatto L; Institute of Biophysics, National Research Council (CNR) Trento unit, Trento 38123, Italy., Virlogeux A; Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, GIN, Grenoble 38000, France., Zuccato C; Department of Biosciences, University of Milan, Milan, Italy; Istituto Nazionale di Genetica Molecolare 'Romeo ed Enrica Invernizzi,' Milan 20122, Italy., Caricasole A; Department of Neuroscience, IRBM S.p.A., Rome 00071, Italy., Ratovitski T; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Ross CA; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Pandey UB; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA., Lucas JJ; Centro de Biología Molecular 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid 28029, Spain., Saudou F; Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, GIN, Grenoble 38000, France. Electronic address: frederic.saudou@inserm.fr., Pennuto M; Dulbecco Telethon Institute, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy; Department of Biomedical Sciences (DBS), University of Padova, Padova 35131, Italy; Veneto Institute of Molecular Medicine (VIMM), via Orus 2, Padova 35129, Italy; Padova Neuroscience Center (PNC), Padova 35131, Italy; Myology Center (CIR-Myo), Padova 35131, Italy. Electronic address: maria.pennuto@unipd.it., Basso M; Laboratory of Transcriptional Neurobiology, Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy. Electronic address: manuela.basso@unitn.it.

Publikováno v: Cell reports [Cell Rep] 2021 Apr 13; Vol. 35 (2), pp. 108980.

Spliceosome-mediated RNA trans -splicing: a strategy for Huntington's disease gene therapy.

Autor: ZHANG, QINGYANG¹ (AUTHOR), HUANG, SHUXIAN¹ (AUTHOR), WENG, DAN¹ (AUTHOR) danweng@njust.edu.cn

Publikováno v: Biocell. 2024, Vol. 48 Issue 10, p1443-1453. 11p.