Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Hernán Pessoa-Mahana"'
Autor:
Analia Young Hwa Cho, Hery Chung, Javier Romero-Parra, Poulami Kumar, Marco Allarà, Alessia Ligresti, Carlos Gallardo-Garrido, Hernán Pessoa-Mahana, Mario Faúndez, Carlos David Pessoa-Mahana
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10918 (2023)
The endocannabinoid system (ECS) constitutes a broad-spectrum modulator of homeostasis in mammals, providing therapeutic opportunities for several pathologies. Its two main receptors, cannabinoid type 1 (CB1) and type 2 (CB2) receptors, mediate anti-
Externí odkaz:
https://doaj.org/article/83430d6cee114e74a40e15077f12a707
Autor:
Juan Andrades-Lagos, Javier Campanini-Salinas, América Pedreros-Riquelme, Jaime Mella, Duane Choquesillo-Lazarte, P. P. Zamora, Hernán Pessoa-Mahana, Ian Burbulis, David Vásquez-Velásquez
Publikováno v:
Antibiotics, Vol 12, Iss 6, p 1065 (2023)
Resistance to antibacterial agents is a growing global public health problem that reduces the efficacy of available antibacterial agents, leading to increased patient mortality and morbidity. Unfortunately, only 16 antibacterial drugs have been appro
Externí odkaz:
https://doaj.org/article/25439a23b8eb439986ae4b0546dc7220
Autor:
Manuel Faúndez-Parraguez, Carlos Alarcón-Miranda, Young Hwa Cho, Hernán Pessoa-Mahana, Carlos Gallardo-Garrido, Hery Chung, Mario Faúndez, David Pessoa-Mahana
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11212 (2021)
The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work we describe the synthesis an
Externí odkaz:
https://doaj.org/article/2de1d0d35de44f458df74e63574d242a
Autor:
Christopher Cerda-Cavieres, Gabriel Quiroz, Patricio Iturriaga-Vásquez, Julio Rodríguez-Lavado, Jazmín Alarcón-Espósito, Claudio Saitz, Carlos D. Pessoa-Mahana, Hery Chung, Ramiro Araya-Maturana, Jaime Mella-Raipán, David Cabezas, Claudia Ojeda-Gómez, Miguel Reyes-Parada, Hernán Pessoa-Mahana
Publikováno v:
Molecules, Vol 25, Iss 20, p 4614 (2020)
A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a–o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fl
Externí odkaz:
https://doaj.org/article/ad09736e79234c8b9134bb4e5a5f08f2
Autor:
Juan Pablo Gonzalez-Gutierrez, Martin Hodar, Franco Viscarra, Pablo Paillali, Nicolás Guerra-Díaz, Hernán Pessoa-Mahana, Juan José Hernández-Morantes, Horacio Pérez-Sánchez, Isabel Bermúdez, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez
Publikováno v:
Molecules, Vol 24, Iss 15, p 2684 (2019)
Neuronal α4β2 nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels (LGIC) that have been implicated in nicotine addiction, reward, cognition, pain disorders, anxiety, and depression. Nicotine has been widely used as a template f
Externí odkaz:
https://doaj.org/article/838d686b3ffa4812a112c5c2aef46ae7
Autor:
Patricio Iturriaga-Vásquez, Carlos David Pessoa-Mahana, Hernán Pessoa-Mahana, Javier Romero-Parra, Christian Espinosa-Bustos, Carlos F. Lagos, Gonzalo Recabarren-Gajardo, Jaime A. Mella-Raipán
Publikováno v:
Molecules, Vol 18, Iss 4, Pp 3972-4001 (2013)
A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affi
Externí odkaz:
https://doaj.org/article/5a69a0bd79f642b2836d736e04e843c8
Autor:
Ramiro Araya-Maturana, Claudio Saitz Barría, Gerald Zapata-Torres, C. David Pessoa-Mahana, Gonzalo Recabarren-Gajardo, Jenny Fiedler Temer, Hernán Pessoa-Mahana
Publikováno v:
Molecules, Vol 17, Iss 2, Pp 1388-1407 (2012)
A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The influence of arylpiperazi
Externí odkaz:
https://doaj.org/article/a43ec701767f40089ad15f2a7b1bef8c
Autor:
GLORIA D GALARCE, ROCÍO E FONCEA, ANA M EDWARDS, HERNÁN PESSOA-MAHANA, CARLOS D PESSOA-MAHANA, ROBERTO A EBENSPERGER
Publikováno v:
Biological Research, Vol 41, Iss 1, Pp 43-50 (2008)
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysacc
Externí odkaz:
https://doaj.org/article/53a531384e474277826538382d5b8c76
Autor:
Pessoa-Mahana, Analia Young Hwa Cho, Hery Chung, Javier Romero-Parra, Poulami Kumar, Marco Allarà, Alessia Ligresti, Carlos Gallardo-Garrido, Hernán Pessoa-Mahana, Mario Faúndez, Carlos David
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10918
The endocannabinoid system (ECS) constitutes a broad-spectrum modulator of homeostasis in mammals, providing therapeutic opportunities for several pathologies. Its two main receptors, cannabinoid type 1 (CB1) and type 2 (CB2) receptors, mediate anti-
Autor:
Vásquez-Velásquez, Juan Andrades-Lagos, Javier Campanini-Salinas, América Pedreros-Riquelme, Jaime Mella, Duane Choquesillo-Lazarte, P. P. Zamora, Hernán Pessoa-Mahana, Ian Burbulis, David
Publikováno v:
Antibiotics; Volume 12; Issue 6; Pages: 1065
Resistance to antibacterial agents is a growing global public health problem that reduces the efficacy of available antibacterial agents, leading to increased patient mortality and morbidity. Unfortunately, only 16 antibacterial drugs have been appro