Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Herminio J Cardona"'
Autor:
Christine M. Hoeman, Francisco J. Cordero, Guo Hu, Katie Misuraca, Megan M. Romero, Herminio J. Cardona, Javad Nazarian, Rintaro Hashizume, Roger McLendon, Paul Yu, Daniele Procissi, Samantha Gadd, Oren J. Becher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein p
Externí odkaz:
https://doaj.org/article/00a70d4e9ad84bf1a869249303aa2d30
Autor:
Aalaa S Abdallah, Herminio J Cardona, Samantha L Gadd, Daniel J Brat, Plamena P Powla, Waleed S Alruwalli, Chen Shen, David J Picketts, Xiao-Nan Li, Oren J Becher
Publikováno v:
Neuro-Oncology Advances. 5
BackgroundPediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7828e8c50944fb0c1f50f5bcd935972f
https://doi.org/10.1093/noajnl/vdad003
https://doi.org/10.1093/noajnl/vdad003
Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension.
Autor:
Marta Perez, Keng Jin Lee, Herminio J Cardona, Joann M Taylor, Mary E Robbins, Gregory B Waypa, Sara K Berkelhamer, Kathryn N Farrow
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0180957 (2017)
Bronchopulmonary dysplasia (BPD), a common complication of preterm birth, is associated with pulmonary hypertension (PH) in 25% of infants with moderate to severe BPD. Neonatal mice exposed to hyperoxia for 14d develop lung disease similar to BPD, wi
Externí odkaz:
https://doaj.org/article/6d0726218e2a4eaa9e7fed304d3f1168
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180384 (2017)
To investigate the impact of photoreceptor oxidative stress on photoreceptor degeneration in mice carrying the rd8 mutation (C57BL/6N). We compared the hyperoxia-induced proliferative retinopathy (HIPR) model in two mouse strains (C57BL/6J and C57BL/
Externí odkaz:
https://doaj.org/article/5a4a8fb7d8664f4ebd429bba6759aac0
Autor:
Michelle Lajko, Herminio J Cardona, Joann M Taylor, Ronil S Shah, Kathryn N Farrow, Amani A Fawzi
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166886 (2016)
Bronchopulmonary dysplasia (BPD) is a major cause of neonatal morbidity in premature infants, occurring as a result of arrested lung development combined with multiple postnatal insults. Infants with BPD exposed to supplemental oxygen are at risk of
Externí odkaz:
https://doaj.org/article/b4508f0dc01e4a788484c3b88d8b0e69
Autor:
Aalaa Abdallah, Herminio J. Cardona, David J. Picketts, Daniel J. Brat, Xiao-Nan Li, Oren J. Becher
Publikováno v:
Cancer Research. 82:912-912
Pediatric High Grade Glioma (pHGG) is a collection of molecularly distinct subtypes with different prognoses depending on the genetic drivers. One particularly aggressive subtype is H3.3G34R mutant gliomas, which are currently incurable and in need o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::080b82f529fff55154978a0e39b0be94
https://doi.org/10.1158/1538-7445.am2022-912
https://doi.org/10.1158/1538-7445.am2022-912
Publikováno v:
Brain and Behavior
Brain and Behavior, Vol 11, Iss 10, Pp n/a-n/a (2021)
Brain and Behavior, Vol 11, Iss 10, Pp n/a-n/a (2021)
Background Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbabff5cfa91822c403ca33e4f8c9e4f
http://europepmc.org/articles/PMC8553322
http://europepmc.org/articles/PMC8553322
Autor:
Javad Nazarian, Guo Hu, Herminio J. Cardona, Daniele Procissi, Paul B. Yu, Rintaro Hashizume, Roger E. McLendon, Megan M. Romero, Samantha Gadd, Oren J. Becher, Katie Misuraca, Francisco Cordero, Christine M. Hoeman
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brain tumor, with approximately 25% of DIPGs harboring activating ACVR1 mutations that commonly co-associate with H3.1K27M mutations. Here we show that in vitro expression of ACVR1 R20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2274ec625a2b0cdb24f93d5f1d7e8f3e
http://europepmc.org/articles/PMC6399349
http://europepmc.org/articles/PMC6399349
Autor:
Kathryn N. Farrow, Marta Perez, Herminio J. Cardona, Keng Jin Lee, Joann M. Taylor, Kamila Wisniewska
Publikováno v:
Pediatric research
BACKGROUND Exposure of neonatal mice to hyperoxia results in pulmonary vascular remodeling and aberrant phosphodiesterase-5 (PDE5) signaling. Although glucocorticoids are frequently utilized in the NICU, little is known about their effects on the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ca1ef773c1bf0d4a240d20d556c356
https://doi.org/10.1038/pr.2016.1
https://doi.org/10.1038/pr.2016.1