Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hermes Licea, Perez"'
Autor:
Hermes Licea, Perez, Clara, Andonian
Publikováno v:
Bioanalysis. 14:1317-1326
Background: The instability of aldehydes in biological matrices is associated with their reactions with thiol and amino moieties in proteins. This chemical reaction is reversible by nature and highly pH dependent. Method: A novel approach that includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb1feefd605186a93a7de017c9993ea
https://doi.org/10.4155/bio-2022-0187
https://doi.org/10.4155/bio-2022-0187
Autor:
Sharon L Boram, Hermes Licea-Perez, Kristen E. Pannullo, Christopher A. Evans, Andrew P Mayer, Jonathan R Kehler
Publikováno v:
Bioanalysis. 13:1427-1439
Aim: Investigations have shown that for the antibody–drug conjugate (ADC) belantamab mafodotin, concentrations of the cysteine-conjugated metabolite, Cys-mcMMAF, were overestimated in the presence of the ADC during sample processing when utilizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7410661dfb96eb1abb5fd94b264d81ca
https://doi.org/10.4155/bio-2021-0171
https://doi.org/10.4155/bio-2021-0171
Autor:
Hermes Licea Perez, Clara Andonian
Publikováno v:
Bioanalysis. 13:985-999
Aim: Quantification of stereoisomers in biological matrices is of pivotal importance for drug development. Supercritical fluid chromatography paired with chiral stationary phases is the gold standard for resolution of enantiomers. However, this techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bfc0da52ec787a2d05935ce97fb1ce
https://doi.org/10.4155/bio-2021-0053
https://doi.org/10.4155/bio-2021-0053
Autor:
Kasie Fang, Hermes Licea-Perez
Publikováno v:
Bioanalysis. 12:467-484
Background: The continual need for the development and validation of ultra-sensitive (low pg/ml) LC–MS/MS assays in the pharmaceutical industry is largely driven by the ultra-low analyte exposure or very low sample volume. Methodology: Strategies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44657fa5a3901666b43ec97982c846e1
https://doi.org/10.4155/bio-2020-0038
https://doi.org/10.4155/bio-2020-0038
Autor:
Kasie, Fang, Hermes, Licea-Perez
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 223:115124
Quantitation of intracellular tri-phosphate anabolite, GSK1-TP, was required to understand drug efficacy of a proprietary molecule, GSK1; while quantitation of the di-phosphate, GSK1-DP, provided an indicator of potential GSK1-TP instability during s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775cad5d9c2ed4f7a029c503e5d7a446
https://doi.org/10.1016/j.jpba.2022.115124
https://doi.org/10.1016/j.jpba.2022.115124
Autor:
Chester L. Bowen, Hermes Licea-Perez, Christopher Matheny, Venkatraman Junnotula, Kasie Fang, Yanwen Qian
Publikováno v:
Analytical Methods. 10:3074-3080
GSK1795091 (or CRX-601), an aminoalkyl glucosaminide 4-phosphate, is a potent TLR4 agonist in clinical development for the treatment of cancer. Bioanalysis of GSK1795091 is challenging as extremely low doses (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7dd4b721b9c01d7dc1168422931d91
https://doi.org/10.1039/c8ay00571k
https://doi.org/10.1039/c8ay00571k
Publikováno v:
Analytical Methods. 9:2603-2610
Bioanalysis of stereoisomers represents a great challenge, as chromatographic separation is not feasible using conventional reversed or normal-phase chromatography. Supercritical fluid chromatography in combination with chiral stationary phases has p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0765f789b9773ff0705a93c40f6d058d
https://doi.org/10.1039/c7ay00452d
https://doi.org/10.1039/c7ay00452d
Autor:
William M. Hardesty, Jonathan Stauber, Lydia Benakli, Rima Ait-Belkacem, Hermes Licea-Perez, Jeremy A. Barry, Stephen Castellino, Clara Andonian
Publikováno v:
Analytical chemistry. 91(9)
The aim of this study was to assess potential sources of variability in quantitative imaging mass spectrometry (IMS) across multiple sites, analysts, and instruments. A sample from rat liver perfused with clozapine was distributed to three sites for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea0c1b6fae44e226a80e802654c70b4
https://pubmed.ncbi.nlm.nih.gov/30938516
https://pubmed.ncbi.nlm.nih.gov/30938516
Publikováno v:
Analytical Methods. 8:3023-3033
Carbohydrate analysis poses many analytical challenges, in terms of extraction, chromatographic separation, and detection. Extraction challenges are associated with poor recovery from biological matrices using conventional techniques such as protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50335eaee4d0fab9fc65f53f7c97371d
https://doi.org/10.1039/c6ay00061d
https://doi.org/10.1039/c6ay00061d
Publikováno v:
Journal of Chromatography B. :7-16
GSK1278863 is an investigative drug under investigation for treatment of anemia associated with chronic kidney disease. Its metabolism is primarily metabolized by P450 enzymes where 19 unique metabolic species have been identified. These include mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872443b10c356d1957d3940e847ccc79
https://doi.org/10.1016/j.jchromb.2015.11.057
https://doi.org/10.1016/j.jchromb.2015.11.057