Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells

Autor: Fern J. Armistead, Julia Gala De Pablo, Hermes Gadêlha, Sally A. Peyman, Stephen D. Evans

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

Abstract Disease can induce changes to subcellular components, altering cell phenotype and leading to measurable bulk-material mechanical properties. The mechanical phenotyping of single cells therefore offers many potential diagnostic applications.

Externí odkaz: https://doaj.org/article/0d0ab460529942fabce44e17105ff0b2

Nonlinear amplitude dynamics in flagellar beating

Autor: David Oriola, Hermes Gadêlha, Jaume Casademunt

Publikováno v: Royal Society Open Science, Vol 4, Iss 3 (2017)

The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets

Externí odkaz: https://doaj.org/article/1c93a50f33884ba5944b80f09b202e05

A coupled immersed interface and level set method for simulation of interfacial flows steered by surface tension

Autor: H. V. R. Mittal, Hermes Gadêlha, Rajendra K. Ray, Dhiraj V. Patil

Publikováno v: HVR Mittal, RK Ray,, Gadêlha, H & DV Patil 2020, ' A coupled immersed interface and level set method for simulation of interfacial flows steered by surface tension ', Experimental and Computational Multiphase Flow . https://doi.org/10.1007/s42757-019-0050-x

This work presents a methodology to address the problems of bubbles and drops evolving in incompressible, viscous flows due to the effect of surface tension. It is based on the combination of a recently developed immersed interface method to resolve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f2eeb19c6cf8c81ab6659a75b9d10b
https://doi.org/10.1007/s42757-019-0050-x

Multiparameter antibiotic resistance detection based on hydrodynamic trapping of individual E. coli

Autor: Steven Johnson, Adrian Evans, Hermes Gadêlha, Thomas F. Krauss, Stephen Thorpe, Giampaolo Pitruzzello

Publikováno v: Pitruzzello, G, Thorpe, S, Johnson, S, Evans, A, Gadêlha, H & Krauss, T F 2019, ' Multiparameter antibiotic resistance detection based on hydrodynamic trapping of individual E. coli ', Lab on a Chip, vol. 19, no. 8, pp. 1417-1426 . https://doi.org/10.1039/C8LC01397G

There is an urgent need to develop novel methods for assessing the response of bacteria to antibiotics in a timely manner. Antibiotics are traditionally assessed via their effect on bacteria in a culture medium, which takes 24-48 h and exploits only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0838111e749dcba321b5b2b40c6249
https://doi.org/10.1039/c8lc01397g

Long-term segmentation-free assessment of head-flagellum movement and intracellular calcium in swimming human sperm

Autor: Fernando Montoya, Gabriel Corkidi, Hermes Gadêlha, Paul Hernandez-Herrera, Alberto Darszon

Publikováno v: Corkidi, G, Hernández-herrera, P, Montoya, F, Gadêlha, H & Darszon, A 2021, ' Long-term segmentation-free assessment of head-flagellum movement and intracellular calcium in swimming human sperm ', Journal of Cell Science, vol. 134, no. 3, jcs250654, pp. jcs.250654 . https://doi.org/10.1242/jcs.250654

Human spermatozoa are the archetype of long-term self-organizing transport in nature and are critical for reproductive success. They utilize coordinated head and flagellar movements to swim long distances within the female reproductive tract in order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a56610b6b80d8117e9bcad391cc64e1
https://research-information.bris.ac.uk/en/publications/12d3ab5e-86c3-46e9-a885-8d7496e1c64c