Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.

Autor: Ishii K; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Hermans SJ; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Georgopoulou ME; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Nero TL; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Hancock NC; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Crespi GAN; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Gorman MA; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Gooi JH; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Parker MW; Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Australia.; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia.

Publikováno v: The FEBS journal [FEBS J] 2024 Sep 26. Date of Electronic Publication: 2024 Sep 26.

Structural biology of cell surface receptors implicated in Alzheimer's disease.

Autor: Hermans SJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Nero TL; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia., Morton CJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia., Gooi JH; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Crespi GAN; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Hancock NC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Gao C; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia.; Present Address: Wren Therapeutics Ltd., Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW UK., Ishii K; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Markulić J; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Parker MW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia.

Publikováno v: Biophysical reviews [Biophys Rev] 2021 Nov 18; Vol. 14 (1), pp. 233-255. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2022).

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.

Autor: Miles LA; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: lmiles@svi.edu.au., Hermans SJ; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Crespi GAN; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Gooi JH; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Doughty L; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Nero TL; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Markulić J; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Ebneth A; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Wroblowski B; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Oehlrich D; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Trabanco AA; Neuroscience Medicinal Chemistry, Janssen Research & Development, 45007 Toledo, Spain., Rives ML; Molecular and Cellular Pharmacology, Janssen Research & Development, LLC, La Jolla, CA 92121, USA., Royaux I; Janssen Research & Development, a Division of Janssen Pharmaceutica N.V, 2340 Beerse, Belgium., Hancock NC; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Parker MW; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3056, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: mparker@svi.edu.au.

Publikováno v: IScience [iScience] 2019 Sep 27; Vol. 19, pp. 110-118. Date of Electronic Publication: 2019 Jul 19.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

Autor: Baell JB; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Jonathan.Baell@monash.edu.; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China. Jonathan.Baell@monash.edu., Leaver DJ; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Hermans SJ; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Kelly GL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Brennan MS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Downer NL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Nguyen N; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wichmann J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., McRae HM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Yang Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Cleary B; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Lagiakos HR; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Mieruszynski S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Pacini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Vanyai HK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Bergamasco MI; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., May RE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Davey BK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Morgan KJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Sealey AJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Wang B; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., Zamudio N; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Wilcox S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Garnham AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Sheikh BN; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Aubrey BJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Doggett K; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Chung MC; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., de Silva M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Bentley J; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Pilling P; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Hattarki M; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dolezal O; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dennis ML; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Falk H; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Ren B; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Newbold A; The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Hawkins ED; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Johnstone RW; The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Huntington ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Peat TS; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Heath JK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Strasser A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Parker MW; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia., Smyth GK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia., Street IP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Monahan BJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. avoss@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. avoss@wehi.edu.au., Thomas T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. tthomas@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. tthomas@wehi.edu.au.

Publikováno v: Nature [Nature] 2018 Aug; Vol. 560 (7717), pp. 253-257. Date of Electronic Publication: 2018 Aug 01.

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

Autor: Hermans SJ; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Melbourne, Victoria, 3065, Australia., Ascher DB, Hancock NC, Holien JK, Michell BJ, Chai SY, Morton CJ, Parker MW

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2015 Feb; Vol. 24 (2), pp. 190-9. Date of Electronic Publication: 2014 Dec 26.