Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Hermann Nawrath"'
Publikováno v:
Journal of Neurophysiology. 98:929-938
As an endogenous agonist at the cannabinoid receptor CB1 and the capsaicin-receptor TRPV1, anandamide may exert both anti- and pronociceptive actions. Therefore we studied the effects of anandamide and other activators of both receptors on changes in
Autor:
Wolfgang Gilles, Ellen I. Closs, Johanna Rupp, Jana F. Liewald, Nicole Vékony, Hermann Nawrath, Sebastian D. Vulcu, Alice Habermeier
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1668:234-239
hCAT-3 (human cationic amino acid transporter type three) was investigated with both the two-electrode voltage clamp method and tracer experiments. Oocytes expressing hCAT-3 displayed less negative membrane potentials and larger voltage-dependent cur
Autor:
Clemens Gillen, Hermann Nawrath, Dirk Faulhammer, Bernd Eschgfäller, Sebastian D. Vulcu, Werner Englberger, Sven Klussmann, Petra Burgstaller, Sandra Stark, Stefan Vonhoff, Frank Kleinjung, Jeannette Erfurth, Werner Schröder, Johanna Rupp
Publikováno v:
RNA. 10:516-527
The neuropeptide nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor, has been shown to play a prominent role in the regulation of several biological functions such as pain and stress. Here we describe
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1660(1-2):138-143
Cationic amino acid transporters play an important role in the intracellular supply of l-Arg and the generation of nitric oxide. Since the transport of l-Arg is voltage-dependent, we aimed at determining the intracellular l-Arg concentration and desc
Autor:
Clemens Gillen, Caroline Wiwie, Sebastian D. Vulcu, Ruth Jostock, Johanna Rupp, Hermann Nawrath
Publikováno v:
Pharmacology. 69:38-43
The vanilloid receptor 1 (VR1) is a heat-activated cation channel which also responds to capsaicin and other chemical stimuli. Protein kinase C has a stimulatory effect on VR1 activity, either alone or after activation with capsaicin. The influence o
Publikováno v:
British Journal of Pharmacology. 136:415-420
1. The effects of the nitric oxide (NO) donors S-nitroso-N-acetylpenicillamine (SNAP), sodium(Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA-NONOate), and (Z)-1-[N-(2-Aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate) o
Publikováno v:
Neuroscience Letters. 320:61-64
Acetylsalicylic acid (ASA) is thought to exert its peripheral analgesic effects via inhibition of cyclooxygenase. We now studied the effects of ASA on heat responses in primary nociceptive neurons by whole-cell patch-clamp and calcium microfluorimetr
Autor:
Johanna Rupp, Ferdinand Hucho, Hermann Nawrath, Clemens Gillen, Mathias Dreger, Linda Diewald
Publikováno v:
Biochemical and Biophysical Research Communications. 291:421-424
ClC chloride channels are important in diverse physiological functions such as transepithelial transport, cell volume regulation, excitability, and acidification of intracellular organelles. We have investigated the expression of CLC-7 in oocytes fro
Autor:
Seung Hyun Kim, Luigi Alberto Pini, Piotr Zimniak, Rebecca P. Martinez, L.P.N. Häckl, Hermann Nawrath, Han-Seop Kim, Giovanni Vitale, Jörg W. Wegener, Kunrong Cheng, Ki-Wan Oh, S. Sanches Dovichi, G. Cuttle, Mauro Nicolau, Jin-Tae Hong, M.T. Lima-Landman, Churl K. Min, In-Seup Yoon, V.K. Bhargava, Myung Koo Lee, Delia Michel, R.K. Dixit, Robert B. Raffa, Chang Ho Lee, Jean-Pierre Raufman, Hack-Seang Kim, Hyun Joo, Maurizio Sandrini, Ying Chen, Taesup Cho
Publikováno v:
Pharmacology. 65:223-226
Publikováno v:
Pharmacology. 65:187-192
The effects of the enantiomers quinine and quinidine on the transient outward current (Ito) and on the L-type Ca2+ current (ICa) were investigated in rat ventricular cardiomyocytes using the patch-clamp technique. At a stimulation frequency of 2 Hz,