Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hermann Gesine Johanna"'
Autor:
Sylvie Gomez, Karine Malagu, Thomas Presnot, Sally Ewen, Mihiro Sunose, Xiao-Ling Fan Cockcroft, Niall M. B. Martin, Alexandra Fundo, Armelle Le Gall, Keith Allan Menear, Hermann Gesine Johanna, Luisa Sebastian, Kristel Blackburn, Ian Hickson, Christine Bailey, Graeme C. M. Smith, Eleanor Torode, Kurt Gordon Pike
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5898-5901
A pharmacophore mapping approach, derived from previous experience of PIKK family enzymes, was used to identify a hit series of selective inhibitors of the mammalian target of rapamycin (mTOR). Subsequent refinement of the SAR around this hit series
Autor:
Lucía Díaz, Marta Corrales, Hermann Gesine Johanna, Robert Alan Goodnow, Peter D. Edwards, Michael C. Annis
Publikováno v:
Synthesis. 2008:221-224
An efficient method for the preparation of novel 3-alkyl- and 3-aryl-4-iodophenols from 3-alkyl- and 3-arylphenols is de- scribed. As part of an ongoing project it was necessary to access a series of novel 4-arylphenols containing sterically de- mand
Autor:
Stephanie Maine, Niall M. B. Martin, Marc Geoffrey Hummersone, Carrie-Anne Molyneaux, Christine Bailey, Sharon Maguire, Frederic Georges Marie Leroux, Hermann Gesine Johanna, Graeme C. M. Smith, Ian Hickson, Mar Jimenez Quesada, James R. Pullen, Heather Mary Ellen Duggan, Keith Allan Menear, Peter D. Edwards, Martin Pass, Sylvie Gomez, Lisa Smith, Jan Drzewiecki, Karine Malagu, Armelle Le Gall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit