Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hermann Bihler"'
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz:
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
Autor:
Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.
Externí odkaz:
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Autor:
Gregory A. Newby, Luke H. Rhym, Hermann Bihler, Zhiping Weng, Martin Mense, Tingting Jiang, Wen Xue, Xiao-Ou Zhang, Y. Cheng, Jordana M. Henderson, H. Valley, Yueying Cao, Anton P. McCaffrey, Daniel G. Anderson, David R. Liu, Qin Wang, Kevin Coote
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain
Autor:
B. Bostwick, Ning Peng, E. Mendenhall, M. Du, Eric Wong, David M. Bedwell, Kim M. Keeling, R. Green, K. Thrasher, Martin Mense, C. Coppola, Venkateshwar Mutyam, M. Suto, Eric J. Sorscher, Jerome Mahiou, L. Fu, J. Wangen, J. Chen, B. Mathew, Yao Li, A. Rab, Hermann Bihler, Jeong S. Hong, Steven M. Rowe, K. Liu, J. Sharma, J. Saltz, Feng Liang, L. Tang, C. Augelli-Szafran
Publikováno v:
Journal of Cystic Fibrosis. 20:S250-S251
Autor:
Martin Mense, Calvin U. Cotton, J. Harrington, N. Allaire, Andrey Sivachenko, J. Conte, B. Tabak, Hermann Bihler, E. Wilson, A. LaPan, H. Valley
Publikováno v:
Journal of Cystic Fibrosis. 20:S302-S303
Autor:
Feng Liang, Nikole J Jordan, H. Valley, L. Wang, Hermann Bihler, H. Shang, K. Coote, A. Bell, Y. Cheng, S. Cantu, Martin Mense
Publikováno v:
Journal of Cystic Fibrosis. 20:S280-S281
Autor:
Hermann Bihler, Carlos M. Farinha, Martin Mense, Zhiwei Cai, Jia Liu, Nikhil T. Awatade, Y. Cheng, Margarida D. Amaral, Dayna Mercadante, Ana M Romão, Isaac Musisi, Yiting Wang, David N. Sheppard, Walailak Jantarajit
Publikováno v:
British Journal of Pharmacology. 175:1017-1038
Background and purpose Rescue of F508del-cystic fibrosis (CF) transmembrane conductance regulator (CFTR), the most common CF mutation, requires small molecules that overcome protein processing, stability and channel gating defects. Here, we investiga
Autor:
J. Meeker, A. Ostmann, A. Streby, D. Joshi, B. Wang, Eric J. Sorscher, C. Barillà, John J. Brewington, H. Morgan, Martin Mense, C. Manfredi, Hermann Bihler, A. Stecenko, George M. Solomon, Y. Cheng, Jeong S. Hong, R. Linnemann, Brian R. Davis, R. O’Shaughnessy, Shingo Suzuki, K. Coote, A. Rab
Publikováno v:
Journal of Cystic Fibrosis. 20:S303
Autor:
A. Werts, M. Glatfelter, M. Mahankali, Z. Yan, E. Yuen, K. Coote, Y. Cheng, Martin Mense, B. Gullick, John F. Engelhardt, Y. Tang, K. Excoffon, P. Kuehl, S. Lin, Hermann Bihler, R. Kolbeck, M. Smith
Publikováno v:
Journal of Cystic Fibrosis. 20:S278